肠道微生物群对心脏衰老的影响

IF 3.5 3区医学 Q2 GERIATRICS & GERONTOLOGY

Archives of gerontology and geriatrics Pub Date : 2024-09-13 DOI:10.1016/j.archger.2024.105639

Zhiyi Yin , Liyao Fu , Yongjun Wang , Shi Tai

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引用次数: 0

摘要

最近的研究表明，肠道微生物群组成失衡是导致心脏衰老的因素之一。个人的身体状况以及与生活方式相关的因素（包括饮食和药物）是决定肠道微生物群组成的重要因素。本综述讨论了衰老与肠道微生物群之间双向关联的证据，指出肠道微生物群衍生的代谢物是心脏衰老的潜在调节因素。它总结了肠道微生物群对心脏衰老疾病的影响，包括心脏肥大和纤维化、心力衰竭和心房颤动。此外，本综述还讨论了通过饮食和药物干预改变肠道微生物群组成的潜在抗衰老作用。最后，它强调了关键的知识空白并概述了未来的研究方向。鉴于目前对肠道微生物群与心脏衰老之间直接关系的了解有限，因此迫切需要对肠道微生物群与心脏衰老之间的机理相互作用进行临床前和临床研究。这些研究有望揭示心脏衰老的病理生理学，并发现心脏衰老疾病的新治疗靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Impact of gut microbiota on cardiac aging

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Impact of gut microbiota on cardiac aging

Recent research has suggested imbalances in gut microbiota composition as contributors to cardiac aging. An individual's physical condition, along with lifestyle-associated factors, including diet and medication, are significant determinants of gut microbiota composition. This review discusses evidence of bidirectional associations between aging and gut microbiota, identifying gut microbiota-derived metabolites as potential regulators of cardiac aging. It summarizes the effects of gut microbiota on cardiac aging diseases, including cardiac hypertrophy and fibrosis, heart failure, and atrial fibrillation. Furthermore, this review discusses the potential anti-aging effects of modifying gut microbiota composition through dietary and pharmacological interventions. Lastly, it underscores critical knowledge gaps and outlines future research directions. Given the current limited understanding of the direct relationship between gut microbiota and cardiac aging, there is an urgent need for preclinical and clinical investigations into the mechanistic interactions between gut microbiota and cardiac aging. Such endeavors hold promise for shedding light on the pathophysiology of cardiac aging and uncovering new therapeutic targets for cardiac aging diseases.

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来源期刊

Archives of gerontology and geriatrics 医学-老年医学

CiteScore

7.30

自引率

5.00%

发文量

198

审稿时长

16 days

期刊介绍： Archives of Gerontology and Geriatrics provides a medium for the publication of papers from the fields of experimental gerontology and clinical and social geriatrics. The principal aim of the journal is to facilitate the exchange of information between specialists in these three fields of gerontological research. Experimental papers dealing with the basic mechanisms of aging at molecular, cellular, tissue or organ levels will be published. Clinical papers will be accepted if they provide sufficiently new information or are of fundamental importance for the knowledge of human aging. Purely descriptive clinical papers will be accepted only if the results permit further interpretation. Papers dealing with anti-aging pharmacological preparations in humans are welcome. Papers on the social aspects of geriatrics will be accepted if they are of general interest regarding the epidemiology of aging and the efficiency and working methods of the social organizations for the health care of the elderly.