耐第三代头孢菌素大肠埃希菌携带儿童的流行病学及相关风险因素:台湾地区间的比较。

IF 2.3 4区 医学 Q2 PEDIATRICS
Wan-Ling Chiang, Hsin Chi, Jia Lu Cheng, Ming-Fang Cheng
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引用次数: 0

摘要

背景:社区中耐药大肠杆菌(E. coli)的流行率不断上升是一项全球性的公共卫生挑战。本研究调查了耐第三代头孢菌素(3GCR)大肠埃希菌在儿童粪便中的携带率,确定了相关风险因素,并确定了台湾三个地区大肠埃希菌的抗菌药耐药性模式:方法:2022 年 7 月至 2023 年 5 月期间,在台湾南部、北部和东部的社区或门诊采集了 0-18 岁儿童的粪便样本。方法:2022 年 7 月至 2023 年 5 月期间,从台湾南部、北部和东部的社区或门诊诊所收集 0-18 岁儿童的粪便样本,筛选出大肠杆菌菌落,并对其进行抗菌药敏感性检测和多焦点序列分型。使用问卷调查了参与者的人口统计学数据和携带耐药大肠杆菌的潜在风险因素:在接受调查的 246 名儿童中,59.3% 的儿童携带耐多药(MDR)大肠杆菌,37.4% 的儿童携带 3GCR 大肠杆菌。3GCR大肠杆菌携带率以台湾南部最高(42.7%),其次是台湾北部(35.5%)和台湾东部(28.4%)。研究发现了一些可能与粪便携带 3GCR 大肠杆菌有关的风险因素,如父亲受教育水平较低、超重或肥胖、荤食和食用鸡蛋等,不同地区的情况也不尽相同:本研究记录了台湾各地区 3GCR 和 MDR 大肠杆菌粪便携带率的升高。研究还发现了许多人口和环境因素,需要实施综合策略来应对这一公共卫生挑战。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Epidemiology of and risk factors associated with third-generation cephalosporin-resistant Escherichia coli carriage in children: A comparison between regions in Taiwan.

Background: The increasing prevalence of antimicrobial-resistant Escherichia coli (E. coli) in the community is a global public health challenge. This study investigated the prevalence of third-generation cephalosporin-resistant (3GCR) E. coli fecal carriage in children, identified associated risk factors, and determined antimicrobial resistance patterns of E. coli across three regions of Taiwan.

Methods: Stool samples from children aged 0-18 years were collected in southern, northern, and eastern Taiwan from community or outpatient clinics between July 2022 and May 2023. E. coli colonies were selected and examined for antimicrobial susceptibility and multilocus sequence typing. Participant demographic data and potential risk factors for carrying resistant E. coli were surveyed using a questionnaire.

Results: Of the 246 children surveyed, 59.3% carried multidrug-resistant (MDR) E. coli, and 37.4% carried 3GCR E. coli. The prevalence of 3GCR E. coli carriage was highest in southern Taiwan (42.7%), followed by northern Taiwan (35.5%) and eastern Taiwan (28.4%). The study identified several risk factors which may be associated with the fecal carriage of 3GCR E. coli, such as having lower paternal education levels, being overweight or obese, having a nonvegetarian diet, and consuming eggs, with variations observed across regions.

Conclusion: This study documented elevated fecal carriage rates of 3GCR and MDR E. coli across regions of Taiwan. The study also identified numerous demographic and environmental factors that require implementing comprehensive strategies to address this public health challenge.

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来源期刊
CiteScore
3.10
自引率
0.00%
发文量
170
审稿时长
48 days
期刊介绍: Pediatrics and Neonatology is the official peer-reviewed publication of the Taiwan Pediatric Association and The Society of Neonatology ROC, and is indexed in EMBASE and SCOPUS. Articles on clinical and laboratory research in pediatrics and related fields are eligible for consideration.
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