机器人辅助全髋关节置换术患者术后关节功能的综合预测模型:结合放射组学和临床指标。

IF 2.2 3区 医学 Q2 SURGERY
Jiewen Zhang, Yiwei Zhao, Yang Chen, Heng Li, Fangze Xing, Chengyan Liu, Xudong Duan, Huanshuai Guan, Ning Kong, Yiyang Li, Kunzheng Wang, Run Tian, Pei Yang
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引用次数: 0

摘要

全髋关节置换术(THA)可有效治疗各种终末期髋关节疾病,缓解疼痛并改善关节功能。然而,手术效果受到多方面因素的影响。本研究旨在建立一个预测模型,结合放射学和临床信息,预测机器人辅助髋关节置换术(RA-THA)患者的术后关节功能。研究对象包括136名接受单侧RA-THA手术的患者,随后将其分为训练集(95人)和测试集(41人)进行分析。利用术前 CT 成像得出 851 个放射学特征,选择类内相关系数大于 0.75 的特征进行分析。最小绝对缩减和选择算子回归将冗余减少到六个重要的放射学特征。临床数据包括术前视觉模拟量表(VAS)、哈里斯髋关节评分(HHS)以及西安大略和麦克马斯特大学骨关节炎指数(WOMAC)。逻辑回归确定了重要的预测因素,并建立了三个模型。接收者操作特征曲线和决策曲线对模型进行了评估。术前VAS、HHS、WOMAC评分和放射组学特征评分是重要的预测因素。在训练集中,AUC 分别为 0.835(临床模型)、0.757(放射组学模型)和 0.891(组合模型)。在测试集中,AUC 分别为 0.777(临床模型)、0.824(放射线组模型)和 0.881(组合模型)。所构建的提名图预测模型结合了放射学特征和相关临床数据,能准确预测 RA-THA 术后 3 年的功能预后。该模型具有明显的预测准确性和广阔的临床应用前景,可为制定个性化治疗方案和优化患者管理策略提供有价值的参考。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A comprehensive predictive model for postoperative joint function in robot-assisted total hip arthroplasty patients: combining radiomics and clinical indicators.

Total hip arthroplasty (THA) effectively treats various end-stage hip conditions, offering pain relief and improved joint function. However, surgical outcomes are influenced by multifaceted factors. This research aims to create a predictive model, incorporating radiomic and clinical information, to forecast post-surgery joint function in robot-assisted THA (RA-THA) patients. The study set comprised 136 patients who underwent unilateral RA-THA, which were subsequently partitioned into a training set (n = 95) and a test set (n = 41) for analysis. Preoperative CT imaging was employed to derive 851 radiomic characteristics, selecting those with an intra-class correlation coefficient > 0.75 for analysis. Least absolute shrinkage and selection operator regression reduced redundancy to six significant radiomic features. Clinical data including preoperative Visual Analog Scale (VAS), Harris Hip Score (HHS), and Western Ontario and McMaster University Osteoarthritis Index (WOMAC) score were collected. Logistic regression identified significant predictors, and three models were developed. Receiver operating characteristic and decision curves evaluated the models. Preoperative VAS, HHS, WOMAC score, and radiomics feature scores were significant predictors. In the training set, the AUCs were 0.835 (clinical model), 0.757 (radiomic model), and 0.891 (combined model). In the test set, the AUCs were 0.777 (clinical model), 0.824 (radiomic model), and 0.881 (combined model). The constructed nomogram prediction model combines radiological features with relevant clinical data to accurately predict functional outcomes 3 years after RA-THA. This model has significant prediction accuracy and broad clinical application prospects and can provide a valuable reference for formulating personalized treatment plans and optimizing patient management strategies.

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来源期刊
CiteScore
4.20
自引率
8.70%
发文量
145
期刊介绍: The aim of the Journal of Robotic Surgery is to become the leading worldwide journal for publication of articles related to robotic surgery, encompassing surgical simulation and integrated imaging techniques. The journal provides a centralized, focused resource for physicians wishing to publish their experience or those wishing to avail themselves of the most up-to-date findings.The journal reports on advance in a wide range of surgical specialties including adult and pediatric urology, general surgery, cardiac surgery, gynecology, ENT, orthopedics and neurosurgery.The use of robotics in surgery is broad-based and will undoubtedly expand over the next decade as new technical innovations and techniques increase the applicability of its use. The journal intends to capture this trend as it develops.
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