笼效应如何影响完全随机设计的统计分析?

IF 1.3 4区 农林科学 Q2 VETERINARY SCIENCES
Laboratory Animals Pub Date : 2024-10-01 Epub Date: 2024-09-24 DOI:10.1177/00236772241276785
Reid D Landes
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引用次数: 0

摘要

笼子效应:有些研究人员担心笼子效应,有些不担心,有些甚至没有意识到笼子效应。当统计分析没有考虑笼子效应时,确实有理由担心。无论研究人员是否担心,所有研究人员都应该意识到笼效应会如何影响研究结果。至于 "如何",部分取决于实验设计。在此,我将(a) 给笼子效应下一个定义;(b) 举例说明动物实验中经常使用的完全随机设计(CRD);(c) 解释当笼子效应被忽视时,统计显著性是如何被人为夸大的;(d) 指导如何进行正确的分析,以及如何提高 CRD 的统计功率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
How cage effects can hurt statistical analyses of completely randomized designs.

Cage effects: some researchers worry about them, some don't, and some aren't even aware of them. When statistical analyses do not account for cage effects, there is real reason to worry. Regardless of researchers' worries or lack thereof, all researchers should be aware of how cage effects can affect the results. The "how" depends, in part, on the experimental design. Here, I (a) define cage effects; (b) illustrate a completely randomized design (CRD) often used in animal experiments; (c) explain how statistical significance is artificially inflated when cage effects are ignored and (d) give guidance on proper analyses and on how to increase statistical power in CRDs.

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来源期刊
Laboratory Animals
Laboratory Animals 生物-动物学
CiteScore
4.90
自引率
8.30%
发文量
64
审稿时长
6-12 weeks
期刊介绍: The international journal of laboratory animal science and welfare, Laboratory Animals publishes peer-reviewed original papers and reviews on all aspects of the use of animals in biomedical research. The journal promotes improvements in the welfare or well-being of the animals used, it particularly focuses on research that reduces the number of animals used or which replaces animal models with in vitro alternatives.
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