{"title":"笼效应如何影响完全随机设计的统计分析?","authors":"Reid D Landes","doi":"10.1177/00236772241276785","DOIUrl":null,"url":null,"abstract":"<p><p>Cage effects: some researchers worry about them, some don't, and some aren't even aware of them. When statistical analyses do <i>not</i> account for cage effects, there is real reason to worry. Regardless of researchers' worries or lack thereof, all researchers should be aware of <i>how</i> cage effects can affect the results. The \"how\" depends, in part, on the experimental design. Here, I (a) define cage effects; (b) illustrate a completely randomized design (CRD) often used in animal experiments; (c) explain how statistical significance is artificially inflated when cage effects are ignored and (d) give guidance on proper analyses and on how to increase statistical power in CRDs.</p>","PeriodicalId":18013,"journal":{"name":"Laboratory Animals","volume":null,"pages":null},"PeriodicalIF":1.3000,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"How cage effects can hurt statistical analyses of completely randomized designs.\",\"authors\":\"Reid D Landes\",\"doi\":\"10.1177/00236772241276785\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Cage effects: some researchers worry about them, some don't, and some aren't even aware of them. When statistical analyses do <i>not</i> account for cage effects, there is real reason to worry. Regardless of researchers' worries or lack thereof, all researchers should be aware of <i>how</i> cage effects can affect the results. The \\\"how\\\" depends, in part, on the experimental design. Here, I (a) define cage effects; (b) illustrate a completely randomized design (CRD) often used in animal experiments; (c) explain how statistical significance is artificially inflated when cage effects are ignored and (d) give guidance on proper analyses and on how to increase statistical power in CRDs.</p>\",\"PeriodicalId\":18013,\"journal\":{\"name\":\"Laboratory Animals\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.3000,\"publicationDate\":\"2024-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Laboratory Animals\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1177/00236772241276785\",\"RegionNum\":4,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/9/24 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"VETERINARY SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Laboratory Animals","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/00236772241276785","RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/9/24 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"VETERINARY SCIENCES","Score":null,"Total":0}
How cage effects can hurt statistical analyses of completely randomized designs.
Cage effects: some researchers worry about them, some don't, and some aren't even aware of them. When statistical analyses do not account for cage effects, there is real reason to worry. Regardless of researchers' worries or lack thereof, all researchers should be aware of how cage effects can affect the results. The "how" depends, in part, on the experimental design. Here, I (a) define cage effects; (b) illustrate a completely randomized design (CRD) often used in animal experiments; (c) explain how statistical significance is artificially inflated when cage effects are ignored and (d) give guidance on proper analyses and on how to increase statistical power in CRDs.
期刊介绍:
The international journal of laboratory animal science and welfare, Laboratory Animals publishes peer-reviewed original papers and reviews on all aspects of the use of animals in biomedical research. The journal promotes improvements in the welfare or well-being of the animals used, it particularly focuses on research that reduces the number of animals used or which replaces animal models with in vitro alternatives.