BRAF/MEK抑制剂相关心脏毒性的风险分层、筛查和治疗。

IF 4.7 2区 医学 Q1 ONCOLOGY
Isabelle Senechal, Maria Sol Andres, Jieli Tong, Sivatharshini Ramalingam, Muhummad Sohaib Nazir, Stuart D Rosen, Kate Young, Praveena Idaikkadar, James Larkin, Alexander R Lyon
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引用次数: 0

摘要

综述的目的:在这篇综述文章中,我们描述了与BRAF和MEK抑制剂相关的心血管不良事件及其病理生理机制,并为对接受治疗的患者进行风险分层监测以及对突发心脏毒性事件进行优化管理提供了最新指导:BRAF/MEK联合抑制疗法已成为多种BRAF突变血液肿瘤和实体器官癌症患者的既定标准治疗方案,最常用于三期和转移性黑色素瘤。这些靶向药物的引入极大地改善了以往耐药癌症的预后。越来越多的人认识到,这些药物有许多心血管毒性,包括左心室收缩功能障碍、高血压和 QTc 间期延长。虽然心脏毒性在很大程度上是可逆的,并可通过药物治疗加以控制,但它确实限制了这些高活性药物的有效使用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Risk Stratification, Screening and Treatment of BRAF/MEK Inhibitors-Associated Cardiotoxicity.

Purpose of review: In this review article we describe the cardiovascular adverse events associated with BRAF and MEK inhibitors as well as their pathophysiologic mechanisms and provide up to date guidance for risk stratified surveillance of patients on treatment and the optimal management of emergent cardiotoxicities.

Recent findings: Combination BRAF/MEK inhibition has become an established standard treatment option for patients with a wide variety of BRAF mutant haematological and solid organ cancers, its use is most commonly associated with stage three and metastatic melanoma. The introduction of these targeted drugs has significantly improved the prognosis of previously treatment resistant cancers. It is increasingly recognised that these drugs have a number of cardiovascular toxicities including left ventricular systolic dysfunction, hypertension and QTc interval prolongation. Whilst cardiotoxicity is largely reversible and manageable with medical therapy, it does limit the effective use of these highly active agents.

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来源期刊
CiteScore
8.50
自引率
0.00%
发文量
187
审稿时长
6-12 weeks
期刊介绍: This journal aims to review the most important, recently published clinical findings in the field of oncology. By providing clear, insightful, balanced contributions by international experts, the journal intends to serve all those involved in the care of those affected by cancer. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as cancer prevention, leukemia, melanoma, neuro-oncology, and palliative medicine. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.
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