预防癌症的药物再利用：针对慢性疾病的共同机制。

IF 2.6 4区医学 Q3 ONCOLOGY

Cancer journal Pub Date : 2024-09-01 DOI:10.1097/PPO.0000000000000746

Nirmal Choradia, Eva Szabo

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引用次数: 0

摘要

摘要：开发预防癌症的药物是一个漫长的过程，需要在潜在干预措施的安全性和耐受性与预防未来癌症的有效性之间取得微妙的平衡。有患某种癌症风险的人往往也有患多种癌症和其他慢性疾病的风险，尤其是与衰老有关的疾病。共同的环境暴露、遗传易感性、代谢因素以及发病机制的共性，都为联合治疗癌症和其他慢性疾病提供了机会。本文讨论的例子包括各种癌症与肥胖症、糖尿病和心血管疾病之间的共同机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Repurposing Drugs for Cancer Prevention: Targeting Mechanisms Common to Chronic Diseases.

Abstract: The development of agents for cancer prevention is a lengthy process requiring a delicate balance between the safety and tolerability of potential interventions and effectiveness in preventing future cancer. Individuals at risk for a specific cancer are frequently at risk for multiple types of cancer as well as other chronic diseases, especially ones associated with aging. Shared environmental exposures, genetic predisposition, metabolic factors, and commonalities in pathogenesis suggest opportunities for combined targeting of cancer and other chronic diseases. Examples discussed here include mechanisms shared between various cancers and obesity, diabetes, and cardiovascular disease.

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来源期刊

Cancer journal 医学-肿瘤学

CiteScore

3.90

自引率

0.00%

发文量

102

审稿时长

7.5 months

期刊介绍： The Cancer Journal: The Journal of Principles & Practice of Oncology provides an integrated view of modern oncology across all disciplines. The Journal publishes original research and reviews, and keeps readers current on content published in the book Cancer: Principles & Practice of Oncology.