身体质量指数与健康相关生活质量之间的相关性：两项减肥干预研究的数据。

IF 3.4 3区医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL

Advances in Therapy Pub Date : 2024-09-24 DOI:10.1007/s12325-024-02932-8

Pavol Kral, Thomas Holst-Hansen, Anamaria V. Olivieri, Cristina Ivanescu, Mark Lamotte, Sara Larsen

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引用次数: 0

摘要

简介：通过 SCALE 和 STEP 1 两项减肥干预研究中收集的与健康相关的生活质量数据，对肥胖症参与者的体重指数（BMI）和效用之间的相关性进行了评估：采用既定算法将 SCALE 和 STEP 1 中的短表健康调查 36 项（SF-36）得分映射到欧洲生活质量-5 维度-3 级（EQ-5D-3L），从而得出英国的效用。使用谢菲尔德大学开发的工具，将 STEP 1 中的 SF-36 分数转换为葡萄牙的简表 6 维度（SF-6D）效用。通过多元线性回归分析评估了基线体重指数与效用之间的相关性，并对人口统计学和临床参数进行了控制：结果：基线体重指数越高，EQ-5D-3L 和 SF-6D 实用性越低，但趋势并不显著。假定体重指数范围在 30-40 kg/m2 之间呈线性关系，则体重指数每增加一个单位，男性和女性在 SCALE 中的 EQ-5D-3L 分数分别降低 0.0041 和 0.0031，在 STEP 1 中的 EQ-5D-3L 分数分别降低 0.0039 和 0.0047，SF-6D 分数分别降低 0.0027 和 0.0020：结论：在具有相似人口统计学特征和体重相关合并症的个体中，体重指数每变化1个单位，效用指数最多相差0.005：试验注册：ClinicalTrials.gov identifiers：SCALE（NCT01272219）和 STEP 1（NCT03548935）。

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The Correlation Between Body Mass Index and Health-Related Quality of Life: Data from Two Weight Loss Intervention Studies

Introduction

The correlation between body mass index (BMI) and utility in participants with obesity was assessed using health-related quality-of-life data collected in two weight loss intervention studies, SCALE and STEP 1.

Methods

Short Form Health Survey 36-Item (SF-36) scores from SCALE and STEP 1 were mapped to EuroQoL-5 dimensions-3 levels (EQ-5D-3L) using an established algorithm to derive utilities for the UK. SF-36 scores from STEP 1 were converted into Short Form 6 dimension (SF-6D) utilities for Portugal using the tool developed by the University of Sheffield. The correlation between baseline BMI and utility was assessed by multiple linear regression analyses, controlling for demographic and clinical parameters.

Results

A higher baseline BMI correlated with lower EQ-5D-3L and SF-6D utilities, although the trend was non-significant. Assuming linearity between BMI ranges 30–40 kg/m², an additional unit of BMI correlated with 0.0041 and 0.0031 lower EQ-5D-3L scores in SCALE and 0.0039 and 0.0047 lower EQ-5D-3L and 0.0027 and 0.0020 lower SF-6D scores in STEP 1 for men and women, respectively.

Conclusion

In individuals with comparable demographic characteristics and weight-related comorbidities, a 1 unit change in BMI leads to a difference of up to 0.005 in utility indices.

Trial Registration

ClinicalTrials.gov identifiers: SCALE (NCT01272219) and STEP 1 (NCT03548935).

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来源期刊

Advances in Therapy 医学-药学

CiteScore

7.20

自引率

2.60%

发文量

353

审稿时长

6-12 weeks

期刊介绍： Advances in Therapy is an international, peer reviewed, rapid-publication (peer review in 2 weeks, published 3–4 weeks from acceptance) journal dedicated to the publication of high-quality clinical (all phases), observational, real-world, and health outcomes research around the discovery, development, and use of therapeutics and interventions (including devices) across all therapeutic areas. Studies relating to diagnostics and diagnosis, pharmacoeconomics, public health, epidemiology, quality of life, and patient care, management, and education are also encouraged. The journal is of interest to a broad audience of healthcare professionals and publishes original research, reviews, communications and letters. The journal is read by a global audience and receives submissions from all over the world. Advances in Therapy will consider all scientifically sound research be it positive, confirmatory or negative data. Submissions are welcomed whether they relate to an international and/or a country-specific audience, something that is crucially important when researchers are trying to target more specific patient populations. This inclusive approach allows the journal to assist in the dissemination of all scientifically and ethically sound research.