程序性细胞死亡与褪黑激素:全面综述。

IF 3.9 4区 生物学 Q1 GENETICS & HEREDITY
Mahdi Rafiyian, Russel J. Reiter, Sayyed Mehdi Rasooli Manesh, Reza Asemi, Mehran Sharifi, Sotoudeh Mohammadi, Mohammad Ali Mansournia, Zatollah Asemi
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引用次数: 0

摘要

褪黑素(MLT)是松果体的主要产物,由于其对多种疾病和细胞平衡的调节作用,最近引起了科学家们的关注。褪黑素受体的广泛分布表明,它对许多器官都有影响。程序性细胞死亡(PCD)有多种类型,由高度保守的机制调节,对不同器官的发育和功能非常重要。增强或抑制程序性细胞死亡可能是治疗不同疾病的有用技术,而 MLT 因其对这些途径的直接影响,是这一策略的良好候选者。许多研究调查了 MLT 在不同疾病的 PCDs 中的作用,在本综述中,我们总结了这一领域最重要的一些研究,以便更好地了解 MLT 调节 PCD 的机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Programmed cell death and melatonin: A comprehensive review

Melatonin (MLT), a main product of pineal gland, recently has attracted the attention of scientists due to its benefits in various diseases and also regulation of cellular homeostasis. Its receptor scares widely distributed indicating that it influences numerous organs. Programmed cell death (PCD), of which there several types, is a regulated by highly conserved mechanisms and important for development and function of different organs. Enhancement or inhibition of PCDs could be a useful technique for treatment of different diseases and MLT, due to its direct effects on these pathways, is a good candidate for this strategy. Many studies investigated the role of MLT on PCDs in different diseases and in this review, we summarized some of the most significant studies in this field to provide a better insight into the mechanisms of modulation of PCD by MLT modulation.

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来源期刊
CiteScore
3.50
自引率
3.40%
发文量
92
审稿时长
2 months
期刊介绍: Functional & Integrative Genomics is devoted to large-scale studies of genomes and their functions, including systems analyses of biological processes. The journal will provide the research community an integrated platform where researchers can share, review and discuss their findings on important biological questions that will ultimately enable us to answer the fundamental question: How do genomes work?
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