Sterre van der Veen MD, PhD, Amber Maliepaard BSc, AM, Madelein van der Stouwe MD, PhD, Jelle Dalenberg PhD, Inge Tuitert PhD, Jan Willem J. Elting MD, PhD, Marina A.J. Tijssen MD, PhD
{"title":"证实皮层肌阵挛的短爆发持续时间","authors":"Sterre van der Veen MD, PhD, Amber Maliepaard BSc, AM, Madelein van der Stouwe MD, PhD, Jelle Dalenberg PhD, Inge Tuitert PhD, Jan Willem J. Elting MD, PhD, Marina A.J. Tijssen MD, PhD","doi":"10.1002/mds.29990","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>Myoclonus is characterized by involuntary, shock-like movements, of which cortical (CM) and non-cortical myoclonus (NCM) are most common. Electrophysiology can help differentiate between these subtypes; however, the diagnostic value of several features is largely unknown.</p>\n </section>\n \n <section>\n \n <h3> Objective</h3>\n \n <p>This study aims to determine the diagnostic value of the burst duration in distinguishing CM and NCM.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>We manually identified the burst duration of 8 patients with CM, confirmed by electromyography–electroencephalography registration or somatosensory-evoked potentials, and 19 patients with NCM, suspected due to a myoclonus-dystonia phenotype (MYC/DYT-<i>SGCE</i> positive and negative).</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>The sensitivity and specificity were calculated to assess the diagnostic value. The burst duration of CM (31.1 ms) was significantly shorter than that of NCM (56.7 ms), with a sensitivity of 100% and a specificity of 89.5% at a threshold of 45.0 ms. A minimum of 10 randomly selected bursts were sufficient for reliable diagnostic accuracy.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>The burst duration seems a valuable supportive diagnostic criterion for distinguishing CM and NCM.</p>\n </section>\n </div>","PeriodicalId":213,"journal":{"name":"Movement Disorders","volume":"39 12","pages":"2275-2280"},"PeriodicalIF":7.4000,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mds.29990","citationCount":"0","resultStr":"{\"title\":\"Substantiating the Short Burst Duration in Cortical Myoclonus\",\"authors\":\"Sterre van der Veen MD, PhD, Amber Maliepaard BSc, AM, Madelein van der Stouwe MD, PhD, Jelle Dalenberg PhD, Inge Tuitert PhD, Jan Willem J. Elting MD, PhD, Marina A.J. Tijssen MD, PhD\",\"doi\":\"10.1002/mds.29990\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Background</h3>\\n \\n <p>Myoclonus is characterized by involuntary, shock-like movements, of which cortical (CM) and non-cortical myoclonus (NCM) are most common. Electrophysiology can help differentiate between these subtypes; however, the diagnostic value of several features is largely unknown.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Objective</h3>\\n \\n <p>This study aims to determine the diagnostic value of the burst duration in distinguishing CM and NCM.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>We manually identified the burst duration of 8 patients with CM, confirmed by electromyography–electroencephalography registration or somatosensory-evoked potentials, and 19 patients with NCM, suspected due to a myoclonus-dystonia phenotype (MYC/DYT-<i>SGCE</i> positive and negative).</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>The sensitivity and specificity were calculated to assess the diagnostic value. The burst duration of CM (31.1 ms) was significantly shorter than that of NCM (56.7 ms), with a sensitivity of 100% and a specificity of 89.5% at a threshold of 45.0 ms. A minimum of 10 randomly selected bursts were sufficient for reliable diagnostic accuracy.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusion</h3>\\n \\n <p>The burst duration seems a valuable supportive diagnostic criterion for distinguishing CM and NCM.</p>\\n </section>\\n </div>\",\"PeriodicalId\":213,\"journal\":{\"name\":\"Movement Disorders\",\"volume\":\"39 12\",\"pages\":\"2275-2280\"},\"PeriodicalIF\":7.4000,\"publicationDate\":\"2024-09-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mds.29990\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Movement Disorders\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/mds.29990\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Movement Disorders","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/mds.29990","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
Substantiating the Short Burst Duration in Cortical Myoclonus
Background
Myoclonus is characterized by involuntary, shock-like movements, of which cortical (CM) and non-cortical myoclonus (NCM) are most common. Electrophysiology can help differentiate between these subtypes; however, the diagnostic value of several features is largely unknown.
Objective
This study aims to determine the diagnostic value of the burst duration in distinguishing CM and NCM.
Methods
We manually identified the burst duration of 8 patients with CM, confirmed by electromyography–electroencephalography registration or somatosensory-evoked potentials, and 19 patients with NCM, suspected due to a myoclonus-dystonia phenotype (MYC/DYT-SGCE positive and negative).
Results
The sensitivity and specificity were calculated to assess the diagnostic value. The burst duration of CM (31.1 ms) was significantly shorter than that of NCM (56.7 ms), with a sensitivity of 100% and a specificity of 89.5% at a threshold of 45.0 ms. A minimum of 10 randomly selected bursts were sufficient for reliable diagnostic accuracy.
Conclusion
The burst duration seems a valuable supportive diagnostic criterion for distinguishing CM and NCM.
期刊介绍：
Movement Disorders publishes a variety of content types including Reviews, Viewpoints, Full Length Articles, Historical Reports, Brief Reports, and Letters. The journal considers original manuscripts on topics related to the diagnosis, therapeutics, pharmacology, biochemistry, physiology, etiology, genetics, and epidemiology of movement disorders. Appropriate topics include Parkinsonism, Chorea, Tremors, Dystonia, Myoclonus, Tics, Tardive Dyskinesia, Spasticity, and Ataxia.
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