纳米金颗粒对血液制品储存质量影响的最新发现(2011-2022 年)--叙述性综述。

Tahereh Zadeh Mehrizi, Seyed Mahdi Rezayat, Hasan Ebrahimi Shahmabadi
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引用次数: 0

摘要

血液制品在储存过程中面临着各种挑战,包括储存病变、必须清除的污染以及化学物质和紫外线照射造成的细胞和蛋白质损伤。金纳米粒子(GNPs)所表现出的稳定性是这些纳米粒子用于储存血液制品的显著优势。我们回顾了 2011 年至 2022 年讨论 GNPs 对血液制品影响的文章,结果发现,在红细胞中,GNPs 的剂量、浓度、数量和表面电荷会显著影响其相容性。纯化的 GNP 与红细胞相容。直径较小、浓度较低的带负电荷 GNP 的相容性更好。不过,在血浆产品中,用不同药剂修饰的纳米粒子表面显示出更大的相容性。与涂有十六烷基三甲基溴化铵和棒状物的纳米球和 GNPs 相比,PEG 化的纳米球和 GNPs 表现出更高的白蛋白构象稳定性。在血小板产品中,较小的 GNP 和高浓度的 GNP 会诱导血小板聚集。PEG 化增加了 GNP 的血小板相容性。将 GNPs 与人纤维蛋白原和氯吡格雷结合可防止血栓形成。最后,这项研究结果表明,GNPs 与其表面电荷、剂量和浓度有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Latest Findings on the Effects of Gold Nanoparticles on the Storage Quality of Blood Products (2011-2022) - A Narrative Review.

A wide range of challenges are faced during the storage of blood products, including storage lesions, contamination that must be removed, and cell and protein damage due to chemicals and UV exposure. The enhancement of stability exhibited by gold nanoparticles (GNPs) is a notable advantage of these nanoparticles for the storage of blood products. The results of our review of articles from 2011 to 2022 discussing the effect of GNPs on blood products revealed that in RBCs, the dose, concentration, amount, and surface charge of GNPs significantly affect their compatibility. Purified GNPs were compatible with RBCs. Negatively charged GNPs with smaller diameters at lower concentrations were more compatible. However, in the plasma product, the nanoparticle surface modification with different agents showed greater compatibility. PEGylated nanospheres and GNPs exhibited higher albumin conformational stability than those coated with cetyltrimethylammonium bromide and rods. In the platelet product, smaller GNPs and high GNP concentrations induce platelet aggregation. PEGylation increased the platelet compatibility of GNP. The combination of GNPs with human fibrinogen and clopidogrel prevented clot formation. Finally, the findings of this investigation demonstrate that GNPs are contingent on their surface charge, dosage, and concentration.

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