不确定潜能克隆造血与心血管疾病：发病机制、临床表现和未来方向。

IF 5.6 2区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Progress in cardiovascular diseases Pub Date : 2024-09-01 DOI:10.1016/j.pcad.2024.09.001

Saivaroon Gajagowni , Steven Hopkins , Yusuf Qadeer , Salim S. Virani , Job A.J. Verdonschot , Catherine C. Coombs , Christopher I. Amos , Kevin T. Nead , Siddhartha Jaiswal , Chayakrit Krittanawong

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引用次数: 0

摘要

具有不确定潜能的克隆性造血（CHIP）是血液系统恶性肿瘤中一种被广泛研究的现象。随着基因取样和分析技术的进步以及大型队列研究的应用，CHIP 最近被认为与心血管疾病（CVD）有关。CHIP 与心血管疾病之间的关系似乎是双向的，心血管疾病的传统风险因素会增加 CHIP 的突变负担，而 CHIP 本身则会影响各种心血管疾病的发病率或预后。本综述旨在从各种心血管疾病的角度了解 CHIP 的流行病学、风险因素和发病机制。

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Clonal hematopoiesis of indeterminate potential and cardiovascular disease: Pathogenesis, clinical presentation, and future directions

Clonal hematopoiesis of indeterminate potential (CHIP) is a well-studied phenomenon in hematologic malignancies. With advancements in gene sampling and analysis and the use of large cohort studies, CHIP has recently been linked to cardiovascular disease (CVD). The relationship between CHIP and CVD appears to be bidirectional, with traditional risk factors for cardiovascular disease increasing the mutation burden in CHIP, and CHIP itself effecting the incidence or prognosis of a variety of CVD. The purpose of this review is to understand the epidemiology, risk factors, and pathogenesis of CHIP in the context of various CVD conditions.

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来源期刊

Progress in cardiovascular diseases 医学-心血管系统

CiteScore

10.90

自引率

6.60%

发文量

审稿时长

7 days

期刊介绍： Progress in Cardiovascular Diseases provides comprehensive coverage of a single topic related to heart and circulatory disorders in each issue. Some issues include special articles, definitive reviews that capture the state of the art in the management of particular clinical problems in cardiology.