髓内脊髓胶质瘤显微手术和术后放疗对神经功能的影响

Xin Li, Zhen-Jie Liu, Liang Liang, Hai-Qing Dong, Xingang Zhao
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引用次数: 0

摘要

研究目的评估联合显微手术和术后放疗治疗髓内脊神经胶质瘤的临床疗效及其对神经功能的影响:观察性研究。研究地点和时间2020年1月至2023年,中国河北省保定市第一中心医院神经外科:将确诊为脊髓髓内胶质瘤的 60 例患者平均分为实验组和对照组。对照组接受显微外科治疗,实验组接受显微外科治疗联合术后放疗。比较两组的治疗效果、神经功能和随访结果:结果:治疗后,实验组的临床疗效明显优于对照组(P 0.05)。实验组术后复发率(0%)明显低于对照组(13.33%,P 结论:实验组术后复发率明显低于对照组(13.33%):显微手术和术后放疗联合治疗比单纯显微手术更有效。它也更有利于神经功能的恢复,并能改善患者的生活质量:髓内脊髓胶质瘤 显微外科手术 神经功能 放疗
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Impact of Microsurgery and Postoperative Radiotherapy on Neurological Function in Intramedullary Spinal Cord Gliomas.

Objective: To assess the clinical efficacy of combined microsurgery and postoperative radiotherapy for the treatment of intramedullary spinal gliomas and its impact on neurological function.

Study design: An observational study. Place and Duration of the Study: Department of Neurosurgery, Baoding No.1 Central Hospital, Hebei, China, between January 2020 and 2023.

Methodology: Sixty patients diagnosed with spinal cord intramedullary gliomas were divided equally into an experimental and control group. The control group received microsurgical treatment, and the experimental group received microsurgical treatment combined with postoperative radiotherapy. The treatment effectiveness, neurological function, and follow-up results of the two groups were compared.

Results: After treatment, the clinical efficacy of the experimental group treatment was significantly better than that of the control group (p <0.05). The National Institutes of Health Stroke Scale (NIHSS) scores were significantly lower, and the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire-30 (EORTC QLQ-C30) scores were significantly higher in the experimental group than in the control group (p <0.05). The 1-3-year survival rate and median survival time of the experimental group were significantly higher than those of the control group (p <0.05). The incidence of complications was 3.33% in the experimental group and 6.67% in the control group, but the difference was not statistically significant (p >0.05). The postoperative recurrence rate was significantly lower in the experimental (0%) than in the control group (13.33%, p <0.05).

Conclusion: Combined microsurgery and postoperative radiotherapy was found to be more effective than microsurgery alone. It was also more conducive to the recovery of neurological function and improved the patient's quality of life.

Key words: Intramedullary spinal cord glioma, Microsurgery, Neurological function, Radiotherapy.

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