卵巢透明细胞癌和高级别浆液性卵巢癌基因表达谱的比较分析

Chen Ye, Gang Hu, Xiaoni Zhou, Wen Deng, Kai Hu, Minglei Fu
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引用次数: 0

摘要

研究目的评估卵巢透明细胞癌(OCCC)和高级别浆液性卵巢癌(HGSOC)之间基因表达谱的差异:描述性研究。研究地点和时间:中国江西省景德镇市第二人民医院,2017年12月31日至2023年12月:对纳入研究组的所有患者的基本信息、临床诊断信息以及基因检测报告进行整理。对两组患者的基因表达差异进行仔细研究,以阐明其临床意义:结果:对比分析发现,OCCC 与 HGSOC 中有 9 个基因表达不同,其中 6 个基因表达有显著差异(p 结论:OCCC 与 HGSOC 之间的基因表达特征不同:OCCC和HGSOC之间不同的基因表达谱突显了不同的致瘤机制,从而为定制治疗干预奠定了基础。有必要进一步阐明已发现的差异表达基因,以明确它们在卵巢透明细胞癌发病机制中的作用和预后意义:卵巢透明细胞癌 高分化浆液性卵巢癌 基因表达谱 同源重组修复
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Comparative Analysis of Gene Expression Profiles in Ovarian Clear Cell Carcinoma and High-Grade Serous Ovarian Cancer.

Objective: To evaluate disparities in gene expression profiles between Ovarian Clear Cell Carcinoma (OCCC) and High-Grade Serous Ovarian Carcinoma (HGSOC).

Study design: A descriptive study. Place and Duration of the Study: The Second People's Hospital of Jingdezhen, Jiangxi, China, between 31st December 2017 and December 2023.

Methodology: Basic and clinical diagnostic information, along with genetic test reports, were compiled from all patients within the included groups. Differential gene expression between the two cohorts was scrutinised to elucidate its clinical significance.

Results: Comparative analysis revealed nine differentially expressed genes in OCCC relative to HGSOC, with six exhibiting significant disparities (p <0.05). These genes are implicated in pivotal cellular processes including the cell cycle, apoptosis, DNA damage repair, and the PI3K pathway. Notably, aberrant expression patterns, such as overexpression of MET and downregulation of PTEN and SMARCA4, correlated with adverse prognosis and survival outcomes in selected patients.

Conclusion: Distinctive gene expression profiles between OCCC and HGSOC underscore disparate tumorigenic mechanisms, thereby laying a foundation for the tailored therapeutic interventions. Further elucidation of the identified differentially expressed genes is warranted to delineate their role in OCCC pathogenesis and prognostic significance.

Key words: Ovarian clear cell carcinoma, High-grade serous ovarian cancer, Gene expression profiles, Homologous recombination repair.

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