美国成年人 C 反应蛋白、生命必需 8 项指标与死亡率之间的关系：NHANES 2005-2010 年数据分析的启示。

IF 3.9

Experimental gerontology Pub Date : 2024-09-21 DOI:10.1016/j.exger.2024.112590

Xin Li, Yongxin Zhu, Tingting Yan, Jie Fang, Xin Xu, Xiaodong Xu

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引用次数: 0

摘要

目的：评估 C 反应蛋白（CRP）和生命之本 8（LE8）对全因和心血管死亡率的独立、中介、交互和相关影响：评估 C 反应蛋白（CRP）和生命之本 8（LE8）对全因死亡率和心血管死亡率的独立、中介、交互和相关影响：利用 2005-2010 年国家健康调查（NHANES）中 10,043 名参与者的数据，我们采用 Cox 比例危险回归模型和因果中介分析来研究生命必需 8（LE8）和 C 反应蛋白（CRP）对死亡风险的联合和交互影响：在平均 137.10 个月的随访期间，共有 1591 例全因死亡和 485 例心血管疾病死亡。加权线性回归显示，对于心血管健康程度低（CVH）的患者，心血管健康程度中等（CVH）的调整后β值为-0.22（95 % CI：-0.27至-0.17），心血管健康程度高（CVH）的调整后β值为-0.36（95 % CI：-0.43至-0.30）。中介分析显示，与低心血管健康水平（CVH）相比，中度心血管健康水平（CVH）的C反应蛋白（CRP）介导了10.43%的全因死亡率和9.20%的心血管死亡率；与低心血管健康水平（CVH）相比，高度心血管健康水平（CVH）的C反应蛋白（CRP）介导了9.95%的全因死亡率和8.32%的心血管死亡率。在全因死亡率或心血管死亡率方面，未发现生命基本指标 8（LE8）与 C 反应蛋白（CRP）之间存在明显的乘法或加法交互作用。与心血管健康水平低（CVH）和C反应蛋白（CRP）处于第一四分位数的人相比，心血管健康水平高（CVH）和C反应蛋白（CRP）处于第一四分位数的人的全因死亡率HR值为0.30（95 % CI 0.18-0.48），心血管死亡率HR值为0.31（95 % CI 0.13-0.74）：这些研究结果表明，CRP 可显著影响心血管健康（CVH）与死亡率之间的关系。针对生活方式因素和 CRP 水平的干预措施可改善心血管健康，并有可能降低死亡风险。

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Association between C-reactive protein, Life's Essential 8, and mortality in American adults: Insights from NHANES 2005–2010 data analysis

Objective

To evaluate the independent, mediating, interactive, and associated effects of C-reactive protein (CRP) and Life's Essential 8 (LE8) on all-cause and cardiovascular mortality.

Methods

Utilizing data from 10,043 participants in the NHANES 2005–2010, we employed Cox proportional hazards regression models and causal mediation analysis to investigate the joint and interactive effects of Life's Essential 8 (LE8) and C-reactive protein (CRP) on mortality risk.

Results

During an average follow-up of 137.10 months, there were 1591 all-cause deaths and 485 cardiovascular deaths. Weighted linear regression showed that for patients with low cardiovascular health (CVH), the adjusted β was −0.22 (95 % CI: −0.27 to −0.17) for moderate cardiovascular health (CVH) and -0.36 (95 % CI: −0.43 to −0.30) for high cardiovascular health (CVH). Mediation analysis revealed that C-reactive protein (CRP) mediated 10.43 % of all-cause mortality and 9.20 % of cardiovascular mortality for moderate cardiovascular health (CVH) compared to low cardiovascular health (CVH), and 9.95 % and 8.32 % respectively for high cardiovascular health (CVH) compared to low cardiovascular health (CVH). No significant multiplicative or additive interactions between Life's Essential 8 (LE8) and C-reactive protein (CRP) were found in all-cause mortality or cardiovascular mortality. Individuals with high cardiovascular health (CVH) and the first quartile of C-reactive protein (CRP) had HRs of 0.30 (95 % CI 0.18–0.48) for all-cause mortality and 0.31 (95 % CI 0.13–0.74) for cardiovascular mortality compared to those with low cardiovascular health (CVH) and the fourth quartile of C-reactive protein (CRP).

Conclusion

These findings suggest that CRP could significantly influence the relationship between cardiovascular health (CVH) and mortality. Interventions that target both lifestyle factors and CRP levels may improve cardiovascular health and potentially lower mortality risks.

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来源期刊

Experimental gerontology Ageing, Biochemistry, Geriatrics and Gerontology

CiteScore

6.70

自引率

0.00%

发文量

审稿时长

66 days