骨化三醇/维生素D受体系统通过上调线粒体生物能与调节HIF-1α/PGC-1α信号传导,减轻PM2.5诱导的人类支气管上皮损伤。

IF 5.4 3区 材料科学 Q2 CHEMISTRY, PHYSICAL
Anyamanee Chatsirisupachai , Phetthinee Muanjumpon , Saowanee Jeayeng , Tasanee Onkoksong , Mutita Pluempreecha , Tanyapohn Soingam , Uraiwan Panich
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引用次数: 0

摘要

PM2.5 暴露会引发氧化应激、线粒体功能障碍和 HIF-1α 信号调节,从而造成肺损伤。钙三醇能激活VDR,而VDR能调节细胞稳态。本研究评估了降钙素三醇/VDR系统在PM2.5诱导的BEAS-2B支气管上皮细胞损伤中通过降低氧化应激、上调线粒体生物能和下调HIF-1α所起的保护作用。我们发现,钙三醇/VDR 系统减少了 ROS 的形成,恢复了 PM2.5 处理细胞的线粒体生物能。这种改善与 HIF-1α 核转位减少、PGC-1α 蛋白和线粒体基因表达增加有关。这项研究首次提出,靶向钙三醇/VDR系统可以通过促进线粒体生物能并调节PGC-1α和HIF-1α信号传导,成为减轻PM2.5诱导的肺上皮损伤的一种有前景的药理学策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Calcitriol/vitamin D receptor system alleviates PM2.5-induced human bronchial epithelial damage through upregulating mitochondrial bioenergetics in association with regulation of HIF-1α/PGC-1α signaling
PM2.5 exposure causes lung injury by triggering oxidative stress, mitochondrial dysfunction, and modulating HIF-1α signaling. Calcitriol activates VDR, which regulates cellular homeostasis. This study evaluated the protective role of the calcitriol/VDR system in PM2.5-induced damage to BEAS-2B bronchial epithelial cells by reducing oxidative stress, upregulating mitochondrial bioenergetics, and downregulating HIF-1α. We found that the calcitriol/VDR system decreased ROS formation and restored mitochondrial bioenergetics in PM2.5-treated cells. This improvement correlated with reduced HIF-1α nuclear translocation and increased PGC-1α protein and mitochondrial gene expressions. This study is the first to suggest that targeting the calcitriol/VDR system could be a promising pharmacological strategy for mitigating PM2.5-induced lung epithelial damage by promoting mitochondrial bioenergetics and regulating PGC-1α and HIF-1α signaling.
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来源期刊
ACS Applied Energy Materials
ACS Applied Energy Materials Materials Science-Materials Chemistry
CiteScore
10.30
自引率
6.20%
发文量
1368
期刊介绍: ACS Applied Energy Materials is an interdisciplinary journal publishing original research covering all aspects of materials, engineering, chemistry, physics and biology relevant to energy conversion and storage. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important energy applications.
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