Rafaella Mendes Zambetta, Étore De Favari Signini, Aparecida Maria Catai, Thainá Cristina Ramos Dos Santos, Eloisa Soares Michaliski, Ana Karoline Nazario, Gabriela Nagai Ocamoto, Gustavo Frigieri, Thiago Luiz Russo
{"title":"-6°头向下倾斜时的ICP脉冲波形P2/P1比值与相对VO2峰值有关吗？无创颅内顺应性监测方法。","authors":"Rafaella Mendes Zambetta, Étore De Favari Signini, Aparecida Maria Catai, Thainá Cristina Ramos Dos Santos, Eloisa Soares Michaliski, Ana Karoline Nazario, Gabriela Nagai Ocamoto, Gustavo Frigieri, Thiago Luiz Russo","doi":"10.1016/j.bas.2024.103327","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Spaceflights influence intracranial compliance (ICC). P2/P1 ratio, from the intracranial pressure (ICP) waveform, provides information about ICC. Additionally, non-invasive methods for ICC monitoring are needed for spaceflights. Furthermore, astronauts try to maintain good levels of cardiorespiratory fitness before and during spaceflights, not only to sustain exploratory missions, but also to prevent diseases in extreme environments.</p><p><strong>Objective: </strong>to correlate cardiorespiratory fitness levels with the P2/P1 ratio during a microgravity analog [-6° head-down tilt (HDT)].</p><p><strong>Method: </strong>34 individuals (11 women), mean age of 31.7 (±6.3) years and BMI 24.2 (±3.2) performed a cardiopulmonary exercise testing (CPET) with an incremental protocol on a cycle ergometer to determine the cardiopulmonary fitness through peak relative oxygen uptake (VO<sub>2</sub> peak) of each individual. On the second test, which was conducted in an interval of 15 days of the CPET, participants remained for 30 min at HDT with P2/P1 ratio acquired using a non-invasive strain gauge sensor. The average of the last 5 min was used for analysis. The mean P2/P1 ratio and relative VO<sub>2</sub> peak were correlated using the Spearman test.</p><p><strong>Results: </strong>Volunteers presented 1.05 ± 0.2 of P2/P1 ratio and VO<sub>2</sub> peak of 47.5 ± 7.6 mL/kg/min. The Spearman test indicated a negative and low correlation between the P2/P1 ratio and VO<sub>2</sub> peak (ρ = -0.388; p = 0.023).</p><p><strong>Conclusion: </strong>The study suggests that the better the cardiorespiratory fitness, the better ICC in a weightlessness simulation.</p>","PeriodicalId":72443,"journal":{"name":"Brain & spine","volume":"4 ","pages":"103327"},"PeriodicalIF":1.9000,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11402318/pdf/","citationCount":"0","resultStr":"{\"title\":\"Is the ICP pulse waveform P2/P1 ratio during -6° head-down tilt associated with relative VO<sub>2</sub> peak? A non-invasive intracranial compliance monitoring approach.\",\"authors\":\"Rafaella Mendes Zambetta, Étore De Favari Signini, Aparecida Maria Catai, Thainá Cristina Ramos Dos Santos, Eloisa Soares Michaliski, Ana Karoline Nazario, Gabriela Nagai Ocamoto, Gustavo Frigieri, Thiago Luiz Russo\",\"doi\":\"10.1016/j.bas.2024.103327\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Spaceflights influence intracranial compliance (ICC). P2/P1 ratio, from the intracranial pressure (ICP) waveform, provides information about ICC. Additionally, non-invasive methods for ICC monitoring are needed for spaceflights. Furthermore, astronauts try to maintain good levels of cardiorespiratory fitness before and during spaceflights, not only to sustain exploratory missions, but also to prevent diseases in extreme environments.</p><p><strong>Objective: </strong>to correlate cardiorespiratory fitness levels with the P2/P1 ratio during a microgravity analog [-6° head-down tilt (HDT)].</p><p><strong>Method: </strong>34 individuals (11 women), mean age of 31.7 (±6.3) years and BMI 24.2 (±3.2) performed a cardiopulmonary exercise testing (CPET) with an incremental protocol on a cycle ergometer to determine the cardiopulmonary fitness through peak relative oxygen uptake (VO<sub>2</sub> peak) of each individual. On the second test, which was conducted in an interval of 15 days of the CPET, participants remained for 30 min at HDT with P2/P1 ratio acquired using a non-invasive strain gauge sensor. The average of the last 5 min was used for analysis. The mean P2/P1 ratio and relative VO<sub>2</sub> peak were correlated using the Spearman test.</p><p><strong>Results: </strong>Volunteers presented 1.05 ± 0.2 of P2/P1 ratio and VO<sub>2</sub> peak of 47.5 ± 7.6 mL/kg/min. The Spearman test indicated a negative and low correlation between the P2/P1 ratio and VO<sub>2</sub> peak (ρ = -0.388; p = 0.023).</p><p><strong>Conclusion: </strong>The study suggests that the better the cardiorespiratory fitness, the better ICC in a weightlessness simulation.</p>\",\"PeriodicalId\":72443,\"journal\":{\"name\":\"Brain & spine\",\"volume\":\"4 \",\"pages\":\"103327\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2024-08-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11402318/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Brain & spine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1016/j.bas.2024.103327\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q3\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Brain & spine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1016/j.bas.2024.103327","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
Is the ICP pulse waveform P2/P1 ratio during -6° head-down tilt associated with relative VO2 peak? A non-invasive intracranial compliance monitoring approach.
Background: Spaceflights influence intracranial compliance (ICC). P2/P1 ratio, from the intracranial pressure (ICP) waveform, provides information about ICC. Additionally, non-invasive methods for ICC monitoring are needed for spaceflights. Furthermore, astronauts try to maintain good levels of cardiorespiratory fitness before and during spaceflights, not only to sustain exploratory missions, but also to prevent diseases in extreme environments.
Objective: to correlate cardiorespiratory fitness levels with the P2/P1 ratio during a microgravity analog [-6° head-down tilt (HDT)].
Method: 34 individuals (11 women), mean age of 31.7 (±6.3) years and BMI 24.2 (±3.2) performed a cardiopulmonary exercise testing (CPET) with an incremental protocol on a cycle ergometer to determine the cardiopulmonary fitness through peak relative oxygen uptake (VO2 peak) of each individual. On the second test, which was conducted in an interval of 15 days of the CPET, participants remained for 30 min at HDT with P2/P1 ratio acquired using a non-invasive strain gauge sensor. The average of the last 5 min was used for analysis. The mean P2/P1 ratio and relative VO2 peak were correlated using the Spearman test.
Results: Volunteers presented 1.05 ± 0.2 of P2/P1 ratio and VO2 peak of 47.5 ± 7.6 mL/kg/min. The Spearman test indicated a negative and low correlation between the P2/P1 ratio and VO2 peak (ρ = -0.388; p = 0.023).
Conclusion: The study suggests that the better the cardiorespiratory fitness, the better ICC in a weightlessness simulation.
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