脊柱关节炎患者的全身自身炎症表现。

IF 3.8 3区医学 Q1 RHEUMATOLOGY

Joint Bone Spine Pub Date : 2024-09-12 DOI:10.1016/j.jbspin.2024.105772

Carla Gaggiano , Mojca Zajc Avramovič , Antonio Vitale , Nina Emeršič , Jurgen Sota , Nataša Toplak , Stefano Gentileschi , Valeria Caggiano , Maria Tarsia , Gašper Markelj , Tina Vesel Tajnšek , Claudia Fabiani , Anja Koren Jeverica , Bruno Frediani , Maria Antonietta Mazzei , Luca Cantarini , Tadej Avčin

{"title":"脊柱关节炎患者的全身自身炎症表现。","authors":"Carla Gaggiano , Mojca Zajc Avramovič , Antonio Vitale , Nina Emeršič , Jurgen Sota , Nataša Toplak , Stefano Gentileschi , Valeria Caggiano , Maria Tarsia , Gašper Markelj , Tina Vesel Tajnšek , Claudia Fabiani , Anja Koren Jeverica , Bruno Frediani , Maria Antonietta Mazzei , Luca Cantarini , Tadej Avčin","doi":"10.1016/j.jbspin.2024.105772","DOIUrl":null,"url":null,"abstract":"<div><h3>Objectives</h3><div>(1) characterizing a group of spondyloarthritis (SpA) patients with systemic auto-inflammatory symptoms (S-SpA); (2) comparing SpA features with and without auto-inflammatory symptoms; (3) comparing the auto-inflammatory features of S-SpA and Still's disease (SD).</div></div><div><h3>Methods</h3><div>Retrospective observational study. Clinical data of adult and pediatric patients with S-SpA, SD or SpA were collected retrospectively and analyzed.</div></div><div><h3>Results</h3><div>Forty-one subjects with S-SpA, 39 with SD and 42 with SpA were enrolled. The median latency between systemic and articular manifestations in S-SpA was 4.4 (IQR: 7.2) years. S-SpA and SpA had similar frequency of peripheral arthritis and enthesitis (N.S.), while tenosynovitis was more frequent (<em>P</em>  <0.01) in S-SpA. MRI showed signs of sacroiliac inflammation and damage in both S-SpA and SpA equally (N.S.). S-SpA patients had less corner inflammatory lesions (<em>P</em>  <0.01), more interspinous enthesitis (<em>P</em>  <0.01). Compared to SD, S-SpA patients had lower-grade fever (<em>P</em>  <0.01) and weight loss (<em>P</em>  <0.01), gastrointestinal symptoms (<em>P</em>  <0.05). ESR, CRP, WBC, ANC, LDH tested higher in SD (<em>P</em>  <0.01) and methotrexate (<em>P</em>    =0.01) and uveitis less frequent (<em>P</em>  <0.05) and inflammation at the facet joints (<em>P</em>  =0.01) and inter-apophyseal capsulitis (<em>P</em>  <0.01), less rash (<em>P</em>  <0.05), but more pharyngitis (<em>P</em>  <0.01) and chest pain (<em>P</em>  <0.01). Resolution of systemic symptoms was less frequent in S-SpA than SD on corticosteroid (<em>P</em>  <0.05) treatment. When considering all SD patients, a complete response to corticosteroids in the systemic phase significantly reduced the likelihood of developing SpA (OR=0.06, coefficient −2.87 [CI: −5.0 to −0.8]).</div></div><div><h3>Conclusions</h3><div>SpA should be actively investigated in patients with auto-inflammatory manifestations, including undifferentiated auto-inflammatory disease and SD.</div></div>\",\"PeriodicalId\":54902,\"journal\":{\"name\":\"Joint Bone Spine\",\"volume\":\"91 6\",\"pages\":\"Article 105772\"},\"PeriodicalIF\":3.8000,\"publicationDate\":\"2024-09-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Joint Bone Spine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1297319X24000836\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"RHEUMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Joint Bone Spine","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1297319X24000836","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"RHEUMATOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

目的：(1) 描述一组伴有系统性自身炎症症状（S-SpA）的脊柱关节炎（SpA）患者的特征；(2) 比较伴有和不伴有自身炎症症状的 SpA 特征；(3) 比较 S-SpA 和 Still's 病（SD）的自身炎症特征：方法：回顾性观察研究。方法：回顾性观察研究，收集并分析成人和儿童 S-SpA、SD 或 SpA 患者的临床数据：结果：41 名 S-SpA、39 名 SD 和 42 名 SpA 患者被纳入研究。S-SpA患者全身表现与关节表现之间的中位潜伏期为4.4年（IQR为7.2年）。S-SpA和SpA的外周关节炎和关节内炎（N.S.）发生率相似，而腱鞘炎发生率较高（P=0.01），葡萄膜炎发生率较低（P=0.01）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Systemic auto-inflammatory manifestations in patients with spondyloarthritis

Objectives

(1) characterizing a group of spondyloarthritis (SpA) patients with systemic auto-inflammatory symptoms (S-SpA); (2) comparing SpA features with and without auto-inflammatory symptoms; (3) comparing the auto-inflammatory features of S-SpA and Still's disease (SD).

Methods

Retrospective observational study. Clinical data of adult and pediatric patients with S-SpA, SD or SpA were collected retrospectively and analyzed.

Results

Forty-one subjects with S-SpA, 39 with SD and 42 with SpA were enrolled. The median latency between systemic and articular manifestations in S-SpA was 4.4 (IQR: 7.2) years. S-SpA and SpA had similar frequency of peripheral arthritis and enthesitis (N.S.), while tenosynovitis was more frequent (P = 0.01) and uveitis less frequent (P < 0.01) in S-SpA. MRI showed signs of sacroiliac inflammation and damage in both S-SpA and SpA equally (N.S.). S-SpA patients had less corner inflammatory lesions (P < 0.05) and inflammation at the facet joints (P < 0.01), more interspinous enthesitis (P = 0.01) and inter-apophyseal capsulitis (P < 0.01). Compared to SD, S-SpA patients had lower-grade fever (P < 0.01), less rash (P < 0.01) and weight loss (P < 0.05), but more pharyngitis (P < 0.01), gastrointestinal symptoms (P < 0.01) and chest pain (P < 0.05). ESR, CRP, WBC, ANC, LDH tested higher in SD (P < 0.01). Resolution of systemic symptoms was less frequent in S-SpA than SD on corticosteroid (P < 0.01) and methotrexate (P < 0.05) treatment. When considering all SD patients, a complete response to corticosteroids in the systemic phase significantly reduced the likelihood of developing SpA (OR = 0.06, coefficient −2.87 [CI: −5.0 to −0.8]).

Conclusions

SpA should be actively investigated in patients with auto-inflammatory manifestations, including undifferentiated auto-inflammatory disease and SD.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Joint Bone Spine 医学-风湿病学

CiteScore

4.50

自引率

11.90%

发文量

184

审稿时长

25 days

期刊介绍： Bimonthly e-only international journal, Joint Bone Spine publishes in English original research articles and all the latest advances that deal with disorders affecting the joints, bones, and spine and, more generally, the entire field of rheumatology. All submitted manuscripts to the journal are subjected to rigorous peer review by international experts: under no circumstances does the journal guarantee publication before the editorial board makes its final decision. (Surgical techniques and work focusing specifically on orthopedic surgery are not within the scope of the journal.)Joint Bone Spine is indexed in the main international databases and is accessible worldwide through the ScienceDirect and ClinicalKey platforms.