膳食植物化学物质对脂肪组织和乳腺肿瘤微环境分泌组的化学预防影响

IF 2 4区医学 Q3 NUTRITION & DIETETICS

Nutrition and Cancer-An International Journal Pub Date : 2025-01-01 Epub Date: 2024-09-19 DOI:10.1080/01635581.2024.2401647

Naoufal Akla, Carolane Veilleux, Borhane Annabi

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引用次数: 0

摘要

癌细胞衍生的细胞外囊泡可促使脂肪间充质干细胞（ADMSC）转变为促炎的、与癌症相关的脂肪细胞（CAA）表型。因此，这种由分泌物介导的脂肪组织与肿瘤微环境（TME）之间的串扰会影响肿瘤的进展和转移过程。此外，膳食中提取的植物化学物质，尤其是表没食子儿茶素-3-棓酸盐（EGCG）和其他多酚，在调节外泌体介导的代谢和炎症信号通路方面的新作用也得到了强调。在此，我们将以乳腺癌为重点，讨论特定的膳食植物化学物质如何改变分泌物组特征以及脂肪组织和肿瘤组织间的串扰动态。此外，我们还讨论了植物化学物质对肥胖相关癌症化学预防的广泛影响。

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The Chemopreventive Impact of Diet-Derived Phytochemicals on the Adipose Tissue and Breast Tumor Microenvironment Secretome.

Cancer cells-derived extracellular vesicles can trigger the transformation of adipose-derived mesenchymal stem cells (ADMSC) into a pro-inflammatory, cancer-associated adipocyte (CAA) phenotype. Such secretome-mediated crosstalk between the adipose tissue and the tumor microenvironment (TME) therefore impacts tumor progression and metastatic processes. In addition, emerging roles of diet-derived phytochemicals, especially epigallocatechin-3-gallate (EGCG) among other polyphenols, in modulating exosome-mediated metabolic and inflammatory signaling pathways have been highlighted. Here, we discuss how selected diet-derived phytochemicals could alter the secretome signature as well as the crosstalk dynamics between the adipose tissue and the TME, with a focus on breast cancer. Their broader implication in the chemoprevention of obesity-related cancers is also discussed.

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来源期刊

Nutrition and Cancer-An International Journal 医学-营养学

CiteScore

5.80

自引率

3.40%

发文量

172

审稿时长

3 months

期刊介绍： This timely publication reports and reviews current findings on the effects of nutrition on the etiology, therapy, and prevention of cancer. Etiological issues include clinical and experimental research in nutrition, carcinogenesis, epidemiology, biochemistry, and molecular biology. Coverage of therapy focuses on research in clinical nutrition and oncology, dietetics, and bioengineering. Prevention approaches include public health recommendations, preventative medicine, behavior modification, education, functional foods, and agricultural and food production policies.