血清炎症因子在预测白癜风合并桥本氏甲状腺炎患者的治疗反应中的作用。

IF 1.4 4区 医学 Q3 ALLERGY
Postepy Dermatologii I Alergologii Pub Date : 2024-08-01 Epub Date: 2024-08-14 DOI:10.5114/ada.2024.142287
Xuwen Yin, Lei Shi, Heng Li, Jianwen Long
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引用次数: 0

摘要

导言:白癜风(VL)与多种自身免疫性疾病相关,尤其是桥本氏甲状腺炎,VL和合并桥本氏甲状腺炎(HT)在VL中的比例高达34%.目的:评估血清炎症因子在指导并发VL和合并HT患者治疗反应中的预测价值:这项回顾性研究共纳入67例VL合并HT患者,根据治疗结果将患者分为不满意组和满意组。分析血清甲状腺指标、自身免疫标记物和炎症因子水平,并对血清炎症因子进行相关性分析:结果:对血清甲状腺指标的研究分析表明,治疗反应不满意组的促甲状腺激素(TSH)、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、甲状腺过氧化物酶(TPO)和甲状腺球蛋白(Tg)水平升高(P < 0.05)。与满意组相比,不满意组患者的 C 反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)和白细胞介素-10(IL-10)等炎症因子水平升高(P < 0.05)。相关分析表明,上述炎症因子的水平与治疗反应呈显著负相关:结论:CRP、TNF-α、IL-6、IL-8、IL-10 与 VL 和并发 HT 的相关性最强,血清炎症因子水平可预测 VL 和并发 HT 患者的治疗反应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The role of serum inflammatory factors in predicting treatment response in patients with vitiligo and concomitant Hashimoto's thyroiditis.

Introduction: Vitiligo (VL) is associated with several autoimmune diseases, especially Hashimoto's thyroiditis, VL and concomitant Hashimoto's thyroiditis (HT) up to 34% in VL.

Aim: To assess the predictive value of serum inflammatory factors in guiding treatment response among patients with concurrent VL and concomitant HT.

Material and methods: This retrospective study enrolled 67 cases of VL and concomitant HT, and the patients according to treatment outcomes were divided into the unsatisfied group and the satisfied group. The serum thyroid parameters, autoimmune markers, and inflammatory factor levels were analysed and the correlation analysis of serum inflammatory factors was made.

Results: The study analysis of serum thyroid parameters showed elevated levels of thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), free thyroxine (FT4), thyroperoxidase (TPO), and thyroglobulin (Tg) (p < 0.05) in the group with unsatisfactory treatment response. Patients in the unsatisfied group exhibited elevated inflammatory factor levels of C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), interleukin-8 (IL-8), and interleukin-10 (IL-10) (p < 0.05) compared to their counterparts in the satisfied group. Correlation analysis showed that the levels of the above inflammatory factors were significantly negatively correlated with the treatment response.

Conclusions: CRP, TNF-α, IL-6, IL-8, IL-10 showed the strongest correlation with VL and concomitant HT, and serum inflammatory factors levels can predict treatment response in patients with VL and concomitant HT.

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来源期刊
CiteScore
2.60
自引率
7.10%
发文量
107
审稿时长
6-12 weeks
期刊介绍: Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii is a bimonthly aimed at allergologists and dermatologists.
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