Aung Zaw Zaw Phyo, Zimu Wu, Sara E Espinoza, Anne M Murray, Peter D Fransquet, Jo Wrigglesworth, Robyn L Woods, Joanne Ryan
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Dementia (Diagnostic and Statistical Manual for Mental Disorders - IV [DSM-IV] criteria) was adjudicated by international experts.</p><p><strong>Results: </strong>Associations between epigenetic AA and cognitive performance over-time varied by sex. In females only, GrimAA/Grim2AA was associated with worse delayed recall, composite cognition, and composite memory (adjusted-beta ranged from -0.1372 to -0.2034). In males only, GrimAA/Grim2AA was associated with slower processing speed (adjusted-beta, -0.3049) and increased dementia risk (adjusted hazard ratios [HRs], 1.78 and 2.00, respectively).</p><p><strong>Discussion: </strong>Epigenetic AA is associated with cognitive deterioration in later life but with evidence of sex-specific associations.</p><p><strong>Highlights: </strong>Epigenetic age acceleration was associated with cognitive deterioration over time.However, these associations differed by sex.In females, accelerated GrimAge appeared to be a better marker of decline in memory.In males, accelerated GrimAge was associated with slower processing speed over time.Association between accelerated GrimAge and dementia risk was found only in males.</p>","PeriodicalId":53226,"journal":{"name":"Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring","volume":"16 3","pages":"e70010"},"PeriodicalIF":4.0000,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11399883/pdf/","citationCount":"0","resultStr":"{\"title\":\"Epigenetic age acceleration and cognitive performance over time in older adults.\",\"authors\":\"Aung Zaw Zaw Phyo, Zimu Wu, Sara E Espinoza, Anne M Murray, Peter D Fransquet, Jo Wrigglesworth, Robyn L Woods, Joanne Ryan\",\"doi\":\"10.1002/dad2.70010\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>This study investigated whether epigenetic age acceleration (AA) is associated with the change in cognitive function and the risk of incident dementia over 9 years, separately in males and females.</p><p><strong>Methods: </strong>Six epigenetic AA measures, including GrimAge, were estimated in baseline blood samples from 560 Australians aged ≥70 years (50.7% female). 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引用次数: 0
摘要
简介：本研究调查了表观遗传年龄加速（AA）是否与男性和女性 9 年间认知功能的变化和痴呆症发病风险有关：这项研究分别调查了男性和女性的表观遗传年龄加速度（AA）是否与认知功能的变化以及9年内发生痴呆症的风险有关：从 560 名年龄≥70 岁的澳大利亚人（50.7% 为女性）的基线血液样本中估算了包括 GrimAge 在内的六项表观遗传年龄加速度测量指标。认知评估包括整体功能、外显记忆、执行功能和精神运动速度。此外，还进行了认知综合评分。痴呆症（《精神疾病诊断与统计手册-IV》[DSM-IV] 标准）由国际专家裁定：结果：表观遗传 AA 与认知能力随时间变化的关系因性别而异。仅在女性中，GrimAA/Grim2AA 与较差的延迟回忆、综合认知和综合记忆相关（调整后的比值范围为-0.1372 至-0.2034）。仅在男性中，GrimAA/Grim2AA 与较慢的处理速度（调整后的比值为-0.3049）和痴呆风险增加（调整后的危险比[HRs]分别为 1.78 和 2.00）有关：讨论：表观遗传 AA 与晚年认知能力衰退有关，但有证据表明存在性别特异性关联：表观遗传年龄加速与认知能力随时间的推移而退化有关，但这些关联因性别而异。在女性中，表观遗传年龄加速似乎是记忆力衰退的更好标志。
Epigenetic age acceleration and cognitive performance over time in older adults.
Introduction: This study investigated whether epigenetic age acceleration (AA) is associated with the change in cognitive function and the risk of incident dementia over 9 years, separately in males and females.
Methods: Six epigenetic AA measures, including GrimAge, were estimated in baseline blood samples from 560 Australians aged ≥70 years (50.7% female). Cognitive assessments included global function, episodic memory, executive function, and psychomotor speed. Composite cognitive scores were also generated. Dementia (Diagnostic and Statistical Manual for Mental Disorders - IV [DSM-IV] criteria) was adjudicated by international experts.
Results: Associations between epigenetic AA and cognitive performance over-time varied by sex. In females only, GrimAA/Grim2AA was associated with worse delayed recall, composite cognition, and composite memory (adjusted-beta ranged from -0.1372 to -0.2034). In males only, GrimAA/Grim2AA was associated with slower processing speed (adjusted-beta, -0.3049) and increased dementia risk (adjusted hazard ratios [HRs], 1.78 and 2.00, respectively).
Discussion: Epigenetic AA is associated with cognitive deterioration in later life but with evidence of sex-specific associations.
Highlights: Epigenetic age acceleration was associated with cognitive deterioration over time.However, these associations differed by sex.In females, accelerated GrimAge appeared to be a better marker of decline in memory.In males, accelerated GrimAge was associated with slower processing speed over time.Association between accelerated GrimAge and dementia risk was found only in males.
期刊介绍：
Alzheimer''s & Dementia: Diagnosis, Assessment & Disease Monitoring (DADM) is an open access, peer-reviewed, journal from the Alzheimer''s Association® that will publish new research that reports the discovery, development and validation of instruments, technologies, algorithms, and innovative processes. Papers will cover a range of topics interested in the early and accurate detection of individuals with memory complaints and/or among asymptomatic individuals at elevated risk for various forms of memory disorders. The expectation for published papers will be to translate fundamental knowledge about the neurobiology of the disease into practical reports that describe both the conceptual and methodological aspects of the submitted scientific inquiry. Published topics will explore the development of biomarkers, surrogate markers, and conceptual/methodological challenges. Publication priority will be given to papers that 1) describe putative surrogate markers that accurately track disease progression, 2) biomarkers that fulfill international regulatory requirements, 3) reports from large, well-characterized population-based cohorts that comprise the heterogeneity and diversity of asymptomatic individuals and 4) algorithmic development that considers multi-marker arrays (e.g., integrated-omics, genetics, biofluids, imaging, etc.) and advanced computational analytics and technologies.
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