雄激素受体激动剂是治疗膀胱癌的一种选择吗？

IF 2.7 2区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Steroid Biochemistry and Molecular Biology Pub Date : 2024-09-19 DOI:10.1016/j.jsbmb.2024.106623

Michael L. De Ieso , Ahmed Faris Aldoghachi , Wayne D. Tilley, Amy R. Dwyer

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引用次数: 0

摘要

膀胱癌的发病率和发展过程中与性别有关的差异推断出性激素及其同源受体在这种疾病中的作用。部分由于雄激素受体信号在前列腺癌中的致癌作用，迄今为止，大多数临床前和临床研究的重点都是雄激素在泌尿系统癌症中的潜在促肿瘤作用。然而，雄激素受体拮抗剂的临床研究收效甚微。在这篇综述中，我们将探讨雄激素受体在膀胱癌中的肿瘤抑制作用，并讨论如何利用雄激素受体进行治疗。

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Are androgen receptor agonists a treatment option in bladder cancer?

Sex-related differences in bladder cancer incidence and progression infer a role for sex hormones and their cognate receptors in this disease. In part due to the oncogenic role of androgen receptor signaling in prostate cancer, the focus of most preclinical and clinical research to-date has been on the potential pro-tumorigenic action of androgens in urothelial cancers. However, clinical studies of androgen receptor antagonism have yielded minimal success. In this review, we explore the tumor suppressor role of androgen receptor in bladder cancer and discuss how it might be harnessed therapeutically.

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来源期刊

Journal of Steroid Biochemistry and Molecular Biology 生物-内分泌学与代谢

CiteScore

8.60

自引率

2.40%

发文量

113

审稿时长

46 days

期刊介绍： The Journal of Steroid Biochemistry and Molecular Biology is devoted to new experimental and theoretical developments in areas related to steroids including vitamin D, lipids and their metabolomics. The Journal publishes a variety of contributions, including original articles, general and focused reviews, and rapid communications (brief articles of particular interest and clear novelty). Selected cutting-edge topics will be addressed in Special Issues managed by Guest Editors. Special Issues will contain both commissioned reviews and original research papers to provide comprehensive coverage of specific topics, and all submissions will undergo rigorous peer-review prior to publication.