验证 GoCheck Kids 眼科筛查工具，以发现佛兰德幼儿弱视的风险因素。

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-10-01 DOI:10.1016/j.jaapos.2024.104008

Hanne Otto MSc , Maaike Deschoemaeker MD , Bart Van Overmeire PhD, MD , Ingele Casteels PhD, MD , Catherine Cassiman PhD, MD

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引用次数: 0

摘要

目的：评估iPhone上的GoCheck Kids照片筛查应用程序（Gobiquity Mobile Health, Scottdale, AZ）的有效性，该应用程序被儿童与家庭（Kind en Gezin）作为标准护理方法（2018-2022年），用于检测12-30个月大儿童的弱视风险因素：2021年8月至2022年5月期间，453名11-16个月大的儿童在比利时佛兰德斯儿童与家庭组织进行GoCheck Kids照片筛查后2个月内接受了眼科确诊检查。此外，GoCheck Kids 的专家还进行了人工复查。诊断指标以美国儿科眼科和斜视协会 2013 年标准为参考进行评估：有无人工审核的自动筛查的特异性相似：结果：有无人工复查的自动筛查的特异性相似：分别为 90.0%（95% CI，87.6%-92.3%）和 90.3%（95% CI，88.0%-92.7%）。自动分级的灵敏度估计为 52.0%（95% CI，35.6%-68.4%），人工复查后的灵敏度估计为 56.0%（95% CI，39.7%-72.3%）。自动筛查和人工复查的阳性预测值分别为 23.2%（95% CI，13.9-32.5）和 25.5%（95% CI，15.8-35.1）。自动筛查和人工复查的阴性预测值分别为 97.0% (95% CI, 95.6-98.4) 和 97.2 (95% CI, 95.8-98.6)：我们的研究对象是 12 个月左右的儿童，GoCheck Kids 应用程序对目标弱视风险因素的特异性为 90%，灵敏度略高于 50%。

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Validation of the eye screening tool GoCheck Kids for the detection of amblyopia risk factors in toddlers in Flanders

Purpose

To assess the validity of the GoCheck Kids photoscreening application (Gobiquity Mobile Health, Scottdale, AZ) on iPhone, which was used (2018-2022) as standard of care by Child and Family (Kind en Gezin) to detect amblyopia risk factors in children 12-30 months of age.

Methods

Between August 2021 and May 2022, 453 children 11-16 months of age underwent a confirmatory ophthalmic examination within 2 months of GoCheck Kids photoscreening at Child and Family, Flanders, Belgium. Additionally, manual review was performed by specialists of GoCheck Kids. Diagnostic metrics were assessed using the 2013 criteria of the American Association for Pediatric Ophthalmology and Strabismus as reference.

Results

Specificity was similar for automatic screening with or without manual review: 90.0% (95% CI, 87.6%-92.3%) and 90.3% (95% CI, 88.0%-92.7%), respectively. Sensitivity was estimated at 52.0% (95% CI, 35.6%-68.4%) for automatic grading and 56.0% (95% CI, 39.7%-72.3%) after manual review. Positive predictive values for automatic screening and manual review were, respectively, 23.2% (95% CI, 13.9-32.5) and 25.5% (95% CI, 15.8-35.1). Negative predictive values for automatic screening and manual review were, respectively, 97.0% (95% CI, 95.6-98.4) and 97.2 (95% CI, 95.8-98.6).

Conclusions

In our study cohort of children around 12 months of age, the GoCheck Kids application had a specificity of 90% for the targeted amblyopia risk factors, with sensitivity just over 50%.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.