常识模型与乳腺癌和卵巢癌遗传易感人群的相关性。

IF 3.5 2区 心理学 Q1 PSYCHOLOGY, CLINICAL
Carole Fantini-Hauwel, Laura Geerts-Crabbé, Pascal Antoine
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引用次数: 0

摘要

研究目的BRCA1/2 基因变异与乳腺癌、卵巢癌、胰腺癌、前列腺癌和黑色素瘤的患病风险增加有关。本研究采用了莱文塔尔的常识自我调节模型(CSM),这是一个强调心理表征对健康威胁反应的作用的理论框架。我们旨在了解遗传性乳腺癌和卵巢癌易感性的个人意义和生活表征:方法:采用解释性现象学分析方法,对 15 名 BRCA 基因携带者的半结构式访谈进行分析:心理表征在童年时期形成,并受到童年时期对 BRCA 遗传倾向的家庭经历的情绪反应的影响。先前存在的关于 BRCA 的信念,即使是错误的,也会深深扎根,不会因为遗传咨询过程中提供的医学信息而受到质疑。当医疗信息被认为过于复杂、不一致或与家庭经验相矛盾时,情况尤其如此。这些关于 BRCA 基因携带者后果的信念会影响情绪和行为体验,导致恐惧、焦虑、对未来缺乏希望或自我身份改变。对于有癌症家族创伤经历的参与者来说,由于缺乏对这种遗传疾病的治疗,他们会长期高估癌症的风险,并感觉到尽管进行了乳房和卵巢预防手术,但仍有与早死相关的无尽危险。当对 BRCA 易感性产生强烈的负面印象时,功能失调的健康行为,如服用药物或过度就医,可能会与情绪失调同时出现。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Relevance of the common-sense model for people living with a genetic predisposition for breast and ovarian cancer

Objectives

BRCA1/2 pathogenic variants have been associated with an increased risk for breast, ovarian, pancreatic, prostate cancer as well as melanoma. The present research uses the Leventhal's common-sense model of self-regulation (CSM), a theoretical framework highlighting the role of mental representations on responses to a health-threat. We aim at understanding the personal meaning and representation of living with an hereditary breast and ovarian cancer predisposition.

Method

Semi-structured interviews of 15 BRCA carriers were analysed using the interpretative phenomenological analysis.

Results

Mental representations develops in childhood and are influenced by childhood emotional responses to the familial experience of the BRCA predisposition. Pre-existing beliefs about BRCA, even erroneous, are deeply anchored and not called into question by medical informations given during the genetic counselling. This is particularly true when medical information is perceived as too complex, inconsistent or in contradiction with familial experience. These beliefs about the consequences of being carriers of the BRCA gene influence emotional and behavioural experiences leading to experience fear, anxiety, lack of hope for future or self-identity change. For participants with a traumatic familial experience of cancer, the lack of treatment for this genetic disease generates a perpetual overestimation of cancers’ risk and the feeling of an unending danger associated with early death despite breast and ovarian prophylactic surgery. When strong negative representations of the BRCA predisposition are experienced, dysfunctional health behaviours, such as drugs consumption or overuse of medical consultations, could appear consecutively to emotional disorders.

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来源期刊
British Journal of Health Psychology
British Journal of Health Psychology PSYCHOLOGY, CLINICAL-
CiteScore
14.10
自引率
1.30%
发文量
58
期刊介绍: The focus of the British Journal of Health Psychology is to publish original research on various aspects of psychology that are related to health, health-related behavior, and illness throughout a person's life. The journal specifically seeks articles that are based on health psychology theory or discuss theoretical matters within the field.
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