学生接种SARS-CoV-2疫苗与抗核抗体发展之间的关系

IF 3 Q1 PRIMARY HEALTH CARE
Karol Laskowski, Justyna Paszkiewicz, Dorota Plewik, Adam Szepeluk, Kamil K Hozyasz
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引用次数: 0

摘要

简介:抗核抗体(ANA)是许多结缔组织疾病(包括狼疮)的标志:抗核抗体(ANA)是许多结缔组织疾病(包括红斑狼疮)的标志,约占导致发病和死亡的慢性衰弱疾病的 5%至 10%。在社会中,对这些疾病的恐惧增加了与疾病有关的不确定性,因为病情发展的预后往往难以确定,而且至少有些症状的波动是不可预测的。在反疫苗接种运动中,疫苗接种与结缔组织疾病和其他自身免疫性疾病之间可能存在的联系问题已逐渐成为反对疫苗接种的重要论据。2021 年,波兰每五名一级护理专业学生中就有一人决定不接种 COVID-19 疫苗:本研究旨在探讨接种和未接种 COVID-19 疫苗的学生体内抗核抗体的流行情况:在波兰的一个小型学术中心开展了一项单一大学横断面研究,该中心在 2022 年招募了 210 名学生。所有参与者均接受了 SARS-CoV-2 IgG 和抗核抗体筛查:拒绝接种疫苗的学生的平均年龄高于接种疫苗的学生。在护理专业学生中,30.0%的接种者和 58.3%的未接种者有 COVID-19。接种过疫苗的学生的抗核抗体频率比未接种过疫苗的学生低 3 倍(2/159 vs 2/51;P > .05):结论:我们的研究结果并未证实因担心健康学生患自身免疫性疾病而拒绝接种 COVID-19 疫苗的合理性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association Between SARS-CoV-2 Vaccination and Development of Antinuclear Antibodies Among Students.

Introduction: Antinuclear antibodies (ANA) are the hallmark of many connective tissue disorders (including lupus), which comprise roughly 5% to 10% of chronic debilitating diseases causing morbidity and mortality. In society, fear of these diseases increases illness-related uncertainty because the prognosis of progression is often difficult to determine and at least some symptoms fluctuate unpredictably. In the anti-vaccination movement, the question of the possible connection between vaccination and connective tissue disorders and other autoimmune diseases has grown to rank as an important argument for rejecting vaccination. In 2021, every fifth Polish first-degree nursing student decided to not be vaccinated against COVID-19.

Objective: This study aimed to explore the prevalence of antinuclear antibodies in students vaccinated and unvaccinated against COVID-19.

Participants and methods: A single university cross-sectional study was performed in a small academic centre in Poland, where 210 students were recruited in 2022. All the participants were screened for SARS-CoV-2 IgG and antinuclear antibodies.

Results: The mean age of the students who rejected vaccination was higher than that of those who were vaccinated. Among nursing students, 30.0% of vaccinated and 58.3% of unvaccinated individuals had COVID-19. The frequency of antinuclear antibodies was 3 times lower in vaccinated students than in unvaccinated students (2/159 vs 2/51; P > .05).

Conclusion: The results of our study did not confirm the rationality of rejecting vaccinations against COVID-19 for fear of developing autoimmune diseases among healthy students.

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来源期刊
CiteScore
4.80
自引率
2.80%
发文量
183
审稿时长
15 weeks
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