接种疫苗对 COVID-19 感染可能性的影响。

IF 1.5 4区 医学 Q4 IMMUNOLOGY
An Hoai Duong, Giang Thi Nguyen, Hien Thi Vu, Lam Xuan Duong, Hue Thi Pham, Ernoiz Antriyandarti
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引用次数: 0

摘要

本研究利用越南和印度尼西亚 5819 名受访者的数据(2022 年 12 月 10 日至 2023 年 3 月 27 日),通过二元逻辑回归研究了 COVID-19 的感染可能性。描述性统计突显了疫苗接种情况的重要性,几乎有一半未接种疫苗的受访者会感染。第二剂疫苗的感染率最低,这表明可能存在剂量依赖效应。接种 mRNA 疫苗的受访者在前四次接种中感染的可能性一直在降低,而第五次接种的情况却出乎意料地发生了逆转。接种疫苗的人,尤其是接种 mRNA 疫苗的人,恢复时间更快,而且在 mRNA 疫苗接种者中观察到恢复时间的变化和较轻的症状。模型 1 的回归结果显示了接种疫苗的重大影响,接种疫苗的受访者比未接种者的几率低 48.1%。模型 2 强调了剂量依赖性的保护效果,每增加一剂疫苗,感染几率明显降低 6.6%。除接种疫苗外,性别、家庭规模、婚姻状况、就业、城市居住地和国籍也会影响感染几率。男性、大家庭、单身婚姻状况、失业、农村居住地和印度尼西亚国籍会增加感染的可能性。令人惊讶的是,有受感染家庭成员的受访者受感染的可能性较低,这表明家庭内部有潜在的保护措施。这些发现凸显了 COVID-19 的动态变化,正在进行的研究将进一步加深对这一现象的理解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Impact of Vaccination on the Likelihood of COVID-19 Infection.

The current study investigates COVID-19 infection likelihood using data from 5,819 respondents in Vietnam and Indonesia (December 10, 2022, to March 27, 2023) through binary logistic regressions. Descriptive statistics highlight the significance of vaccination status, with almost half of unvaccinated respondents contracting the infection. The second vaccine dose showed the lowest infection percentages, suggesting a potential dose-dependent effect. Those receiving mRNA vaccines consistently had reduced infection likelihood across the first four doses, with an unexpected reversal for the fifth dose. Vaccinated individuals, especially with mRNA vaccines, had faster recovery times, and variability in recovery times and milder symptoms were observed in mRNA vaccine recipients. Regression results from Model 1 reveal a substantial impact of vaccination, with vaccinated respondents having ∼48.1% lower odds than the unvaccinated. Model 2 underscores a dose-dependent protective effect, with each additional dose associated with a notable 6.6% reduction in infection likelihood. Beyond vaccination, gender, family size, marital status, employment, urban residence, and nationality influenced infection likelihood. Males, larger families, single marital status, unemployment, rural residence, and Indonesian nationality increased the likelihood of infection. Surprisingly, respondents with infected family members exhibited a lower infection likelihood, suggesting potential protective measures within households. These findings highlight COVID-19 dynamics, and ongoing research refines comprehension.

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来源期刊
Viral immunology
Viral immunology 医学-病毒学
CiteScore
3.60
自引率
0.00%
发文量
84
审稿时长
6-12 weeks
期刊介绍: Viral Immunology delivers cutting-edge peer-reviewed research on rare, emerging, and under-studied viruses, with special focus on analyzing mutual relationships between external viruses and internal immunity. Original research, reviews, and commentaries on relevant viruses are presented in clinical, translational, and basic science articles for researchers in multiple disciplines. Viral Immunology coverage includes: Human and animal viral immunology Research and development of viral vaccines, including field trials Immunological characterization of viral components Virus-based immunological diseases, including autoimmune syndromes Pathogenic mechanisms Viral diagnostics Tumor and cancer immunology with virus as the primary factor Viral immunology methods.
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