狂犬病暴露后预防：对比利时队列中的启动时间和抗体反应的回顾性分析。

IF 6.3 3区医学 Q1 INFECTIOUS DISEASES

Travel Medicine and Infectious Disease Pub Date : 2024-09-19 DOI:10.1016/j.tmaid.2024.102761

Matilde Hens , Steven Declercq , Nicole Berens-Riha , Ula Maniewski , Caroline Theunissen , Steven Van Den Broucke , Felix De Bièvre , Isabel Brosius , Laurens Liesenborghs , Christophe Van Dijck , Christophe Burm , Inne Nauwelaers , Katleen Balliauw , Benjamin J. Visser , Emmanuel Bottieau , Patrick Soentjens

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引用次数: 0

摘要

背景：我们旨在确定狂犬病暴露后预防（PEP）的及时性，以及在比利时国家参考中心就诊的患者中，PEP后抗体反应充分者的比例：回顾性分析2018-2023年在本中心就诊的患者记录。延迟的定义是狂犬病免疫球蛋白（RIG）和疫苗接种时间超过暴露后 2 个日历日。在高风险暴露的 PEP 后，通过快速荧光聚焦抑制试验（RFFIT）测量抗体。结果：我们审查了 317 份患者病历。在内陆接触者（人数=103）中，85%及时接受了PEP。在暴露于国外的旅行者（人数=214）中，分别有 30% 和 50% 的病例及时注射了 RIG 和疫苗。99.5%（195/196）的人检测到了足够的抗体反应：结论：在旅行者中发现了大量的 PEP 延误。强大的抗体反应表明，没有必要对所有患者进行常规血清学随访。

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Rabies post-exposure prophylaxis: A retrospective analysis of timing of initiation and antibody responses in a Belgian cohort

Background

We aimed to determine the timeliness of rabies post-exposure prophylaxis (PEP) and the proportion of individuals with an adequate antibody response post-PEP among those attending the Belgian national reference center.

Methods

Retrospective analysis of patient records who attended our center from 2018 to 2023. Delay was defined as rabies immunoglobulin (RIG) and vaccine initiation beyond 2 calendar days after exposure. Antibodies were measured by rapid fluorescent focus inhibition test (RFFIT) after PEP in high-risk exposures. A titer ≥0.5 IU/ml was considered adequate.

Results

We reviewed 317 patient records. Among individuals with inland exposure (n = 103), 85 % timely received PEP. Among travelers exposed abroad (n = 214), administration of RIG and vaccine initiation were timely in 30 % and 50 % of cases, respectively. An adequate antibody response was detected in 99.5 % (195/196) individuals.

Conclusion

Substantial PEP delays among travelers were observed. The robust antibody responses suggest that routine serological follow-up is not necessary for all patients.

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来源期刊

Travel Medicine and Infectious Disease PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-INFECTIOUS DISEASES

CiteScore

19.40

自引率

1.70%

发文量

211

审稿时长

49 days

期刊介绍： Travel Medicine and Infectious Disease Publication Scope: Publishes original papers, reviews, and consensus papers Primary theme: infectious disease in the context of travel medicine Focus Areas: Epidemiology and surveillance of travel-related illness Prevention and treatment of travel-associated infections Malaria prevention and treatment Travellers' diarrhoea Infections associated with mass gatherings Migration-related infections Vaccines and vaccine-preventable disease Global policy/regulations for disease prevention and control Practical clinical issues for travel and tropical medicine practitioners Coverage: Addresses areas of controversy and debate in travel medicine Aims to inform guidelines and policy pertinent to travel medicine and the prevention of infectious disease Publication Features: Offers a fast peer-review process Provides early online publication of accepted manuscripts Aims to publish cutting-edge papers