释放去铁胺的潜能:与标准疗法相比,系统回顾去铁胺在减轻心肺搭桥术后成年患者心肌缺血再灌注损伤方面的疗效和安全性。

IF 2.6 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS
Aashish Lamichhane, Sadish Sharma, Bishwas Bastola, Bikesh Chhusyabaga, Nabin Shrestha, Prajwal Poudel
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引用次数: 0

摘要

背景:以氧化应激和炎症为特征的再灌注损伤是心肺旁路(CPB)心脏手术的一大挑战。去铁胺是一种铁螯合化合物,通过抑制铁依赖性脂质过氧化和活性氧(ROS)的产生,有望减轻再灌注损伤:我们的研究旨在分析和评估一种新的、有前景的干预措施,即去铁胺治疗缺血再灌注损伤(I/R)的有效性和安全性:设计:采用系统综述和荟萃分析首选报告项目(PRISMA)指南进行研究:我们按照 PRISMA 指南进行了一项系统性综述,以评估去铁胺在减少 CPB 后 I/R 损伤方面的有效性和安全性。我们对电子数据库(即 PubMed、Scopus 和 Embase)进行了全面检索,发现了截至 2023 年 8 月 18 日发表的相关研究。结果:(a)ROS 生成:多项研究表明,接受去铁胺治疗的患者体内 ROS 生成量在统计学上有显著下降,这突显了去铁胺降低氧化应激的潜力。(b) 脂质过氧化:去铁胺与脂质过氧化水平的降低有关,表明去铁胺能够保护心脏组织在 CPB 期间免受氧化损伤。(c) 心脏性能:一些研究报告称,使用去铁胺可改善左心室射血分数和室壁运动评分指数:我们的综述显示,去铁胺是一种有效且安全的药物,可用于预防 CPB 后的心肌 I/R 损伤。结论:我们的综述表明,去铁胺是一种有效、安全的药物,可用于预防 CPB 后的心肌 I/R 损伤,同时也强调了需要进行更大规模的试验,以制定使用去铁胺治疗 I/R 损伤的潜在策略和指南。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Unlocking the potential of deferoxamine: a systematic review on its efficacy and safety in alleviating myocardial ischemia-reperfusion injury in adult patients following cardiopulmonary bypass compared to standard care.

Background: Reperfusion injury, characterized by oxidative stress and inflammation, poses a significant challenge in cardiac surgery with cardiopulmonary bypass (CPB). Deferoxamine, an iron-chelating compound, has shown promise in mitigating reperfusion injury by inhibiting iron-dependent lipid peroxidation and reactive oxygen species (ROS) production.

Objectives: The objective of our study was to analyze and evaluate both the efficacy and safety of a new and promising intervention, that is, deferoxamine for ischemia-reperfusion injury (I/R).

Design: Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines are used to perform the study.

Data sources and methods: We conducted a systematic review following PRISMA guidelines to assess the efficacy and safety of deferoxamine in reducing I/R injury following CPB. A comprehensive search of electronic databases, namely, PubMed, Scopus, and Embase, yielded relevant studies published until August 18, 2023. Included studies evaluated ROS production, lipid peroxidation, cardiac performance, and morbidity outcomes.

Results: (a) ROS production: Multiple studies demonstrated a statistically significant decrease in ROS production in patients treated with deferoxamine, highlighting its potential to reduce oxidative stress. (b) Lipid peroxidation: Deferoxamine was associated with decreased lipid peroxidation levels, indicating its ability to protect cardiac tissue from oxidative damage during CPB. (c) Cardiac performance: Some studies reported improvements in left ventricular ejection fraction and wall motion score index with deferoxamine.

Conclusion: Our review shows that deferoxamine is an efficacious and safe drug that can be used to prevent myocardial I/R injury following CPB. It also highlights the need for trials on a larger scale to develop potential strategies and guidelines on the use of deferoxamine for I/R injury.

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来源期刊
Therapeutic Advances in Cardiovascular Disease
Therapeutic Advances in Cardiovascular Disease CARDIAC & CARDIOVASCULAR SYSTEMS-
CiteScore
3.50
自引率
0.00%
发文量
11
审稿时长
9 weeks
期刊介绍: The journal is aimed at clinicians and researchers from the cardiovascular disease field and will be a forum for all views and reviews relating to this discipline.Topics covered will include: ·arteriosclerosis ·cardiomyopathies ·coronary artery disease ·diabetes ·heart failure ·hypertension ·metabolic syndrome ·obesity ·peripheral arterial disease ·stroke ·arrhythmias ·genetics
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