COVID-19 重症和危重症幸存者组群的 6 个月和 12 个月呼吸系统预后:拉丁美洲前瞻性单中心研究。

IF 2.3 Q2 MEDICINE, GENERAL & INTERNAL
SAGE Open Medicine Pub Date : 2024-09-09 eCollection Date: 2024-01-01 DOI:10.1177/20503121241275369
Liliana Fernández-Trujillo, Juan Sebastián Galindo-Sánchez, Angie Cediel, Carlos A García, Eliana I Morales, Jessica Largo, María A Amezquita-Dussan
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引用次数: 0

摘要

导言:严重的 COVID-19 可导致被称为 "慢性 COVID "的长期后遗症,其特征是一系列持续的身体和精神症状。康复患者的胸部影像和肺功能测试均有改变。大多数研究侧重于发病或出院后最多 3 个月的随访,有关长期随访的报告很少,拉丁美洲有关疾病进展的证据也很有限:本研究旨在描述拉丁美洲一家综合医院中需要入住重症监护室的 COVID-19 重症和危重患者的临床特征以及肺功能、影像学和生活质量的变化。一组前瞻性幸存者在出院后 6 个月和 12 个月接受了临床、放射学、肺功能和生活质量评估:结果:共纳入 112 名患者,他们都参加了 6 个月的随访,其中 99 人参加了 12 个月的随访。大多数受试者之前没有呼吸系统症状或重大病史。在随访期结束时,74%的患者在胸部断层扫描中显示出间质浸润,纤维导水管和实质带的出现频率较高。肺功能测试恢复到正常范围,一氧化碳扩散除外,但调查问卷中的评分没有变化:结论:尽管有残留的影像学结果,但在12个月的随访期间,COVID-19重症和危重症幸存者的大多数参数都有所改善。无论影像异常如何,症状缓解和肺功能正常等变量的改善都表明这些改变是短暂的。一氧化碳弥散在随访结束时并未恢复正常,这与多项研究中报告的异常情况一致,表明可能存在与疾病相关的模式。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Six and twelve-month respiratory outcomes in a cohort of severe and critical COVID-19 survivors: A prospective monocentric study in Latin America.

Introduction: Severe COVID-19 can result in long-term sequelae known as "chronic COVID," characterized by a wide range of persistent physical and mental symptoms. Chest imaging and pulmonary function test alterations have been observed in recovered patients. Most studies focus on up to a 3-month follow-up after symptom onset or hospital discharge, with few reports on long-term follow-up and limited evidence regarding disease progression in Latin America.

Methods: This study aims to describe the clinical characteristics and changes in pulmonary function, imaging, and quality of life in severe and critical COVID-19 patients requiring ICU admission in a high-complexity hospital in Latin America. A prospective cohort of survivors underwent clinical, radiological, pulmonary function, and quality of life assessments 6 and 12 months post-discharge.

Results: One hundred twelve patients were included, all of whom attended the 6-month follow-up, and 99 returned for the 12-month follow-up. Most subjects had no previous respiratory symptoms or significant medical history. At the end of the follow-up period, 74% of the patients showed interstitial infiltrates in chest tomography and a higher frequency of fibroatelectatic tracts and parenchymal bands. Pulmonary function tests returned to normal ranges, except for carbon monoxide diffusion, but no altered scores were reported in the questionnaires.

Conclusion: Despite residual radiological findings, most parameters studied in severe and critical COVID-19 survivors improved over the 12-month follow-up period. Regardless of the imaging abnormalities, the improvement in variables such as symptomatic relief and normal pulmonary function suggests that these alterations are transient. Carbon monoxide diffusion did not normalize by the end of the follow-up, which is consistent with the abnormalities reported in multiple studies, indicating a potential disease-related pattern.

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来源期刊
SAGE Open Medicine
SAGE Open Medicine MEDICINE, GENERAL & INTERNAL-
CiteScore
3.50
自引率
4.30%
发文量
289
审稿时长
12 weeks
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