鱼油对接受血液透析的成年患者控制炎症的效果:系统回顾和荟萃分析。

IF 2.3 Q2 MEDICINE, GENERAL & INTERNAL
SAGE Open Medicine Pub Date : 2024-09-10 eCollection Date: 2024-01-01 DOI:10.1177/20503121241275467
Kaneez Fatima, Aysal Mahmood, Faiza Zafar Sayeed, Maryam Raza, Rahima Azam, Nazish Waris, Muttia Abdul Sattar, Teesha Rani, Zainab Wahaj, Danisha Kumar, Simra Nadeem Siddiqui
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引用次数: 0

摘要

目的:慢性肾脏病血液透析患者通常表现出以 C 反应蛋白、白细胞介素 6 和肿瘤坏死因子-α 水平升高为特征的炎症,并被证明与心血管损伤和肾功能衰竭加剧有关。本研究旨在评估鱼油摄入量对成年血液透析患者炎症指标的影响:方法:研究人员查阅了从开始到 2023 年 12 月的 Cochrane Central、Google Scholar、Science Direct、Embase 和 Pubmed 数据集。两位作者独立检索、筛选文献。汇总结果以加权平均差(WMD)和 95% 置信区间表示。为研究异质性的原因,进行了亚组分析。然后使用敏感性分析来评估综合结果的有效性:结果:共纳入 13 项随机对照试验研究。汇总结果显示,补充鱼油可显著降低 C 反应蛋白水平(WMD,-2.92 mg/L;95% 置信区间,-5.23 至 -0.61;p = 0.01;I 2 = 99%),尤其是基线 C 反应蛋白 ⩾5 mg/L 的患者(WMD,-4.39 mg/L;95% 置信区间,-5.93 至 2.85;p I 2 = 33%)。亚组分析显示,C 反应蛋白基线水平(C 反应蛋白 p = 0.80;I 2 = 93%),也不会降低肿瘤坏死因子-α 的水平(随机模型:结论:结论:血液透析患者,尤其是C反应蛋白大于5毫克/升的患者,补充鱼油可降低其C反应蛋白水平;但白细胞介素6和肿瘤坏死因子-α的水平似乎并未受到影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effectiveness of fish oil in controlling inflammation in adult patients undergoing hemodialysis: A systematic review and meta-analysis.

Objective: Hemodialysis patients with chronic kidney disease often exhibit inflammation characterized by elevated levels of C-reactive protein, Interleukin 6 and tumor necrosis factor-alpha, and they are shown to be associated with cardiovascular impairment and enhanced renal failure. This study aims to assess the impact of fish oil intake on inflammation indicators in adult hemodialysis patients.

Methods: From the inception to December 2023, the datasets Cochrane Central, Google Scholar, Science Direct, Embase, and Pubmed were examined. Two authors independently searched, selected, and screened the literature. The pooled results are represented by weighted mean difference (WMD) with 95% confidence intervals. To investigate the causes of heterogeneity, subgroup analysis was done. Sensitivity analysis was then used to evaluate the validity of the combined findings.

Results: Thirteen randomized control trials studies were included. The pooled results showed that fish oil supplementation caused a significant reduction of the C-reactive protein level (WMD, -2.92 mg/L; 95% Confidence interval, -5.23, to -0.61; p = 0.01; I 2 = 99%), especially in patients with baseline C-reactive protein ⩾5 mg/L (WMD, -4.39 mg/L; 95% Confidence interval, -5.93 to 2.85; p < 0.00001; I 2 = 33%). Subgroup analyses showed that C-reactive protein baseline level (C-reactive protein <5 mg/L) was the main source of heterogeneity. Fish oil intake may not reduce the level of Interleukin 6 (WMD, -2.26; 95% Confidence interval: -19.61 to 15.09; p = 0.80; I 2 = 93%), nor will it reduce the level of tumor necrosis factor-alpha (random model: WMD, -2.51; 95% Confidence interval: 6.08 to 1.06; p = 0.17; I 2 = 98%).

Conclusion: Hemodialysis patients, especially those with C-reactive protein > 5 mg/L, responded to fish oil supplementation to reduce their C-reactive protein level; however, Interleukin 6 and tumor necrosis factor-alpha levels did not appear to be affected.

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来源期刊
SAGE Open Medicine
SAGE Open Medicine MEDICINE, GENERAL & INTERNAL-
CiteScore
3.50
自引率
4.30%
发文量
289
审稿时长
12 weeks
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