硼雷利定和福马吉林对疟原虫感染小鼠的抗疟活性。

IF 0.9 Q3 VETERINARY SCIENCES
Open Veterinary Journal Pub Date : 2024-08-01 Epub Date: 2024-08-31 DOI:10.5455/OVJ.2024.v14.i8.30
Risqa Novita, Agik Suprayogi, Andria Agusta, Arifin Budiman Nugraha, Tomoyoshi Nozaki, Kurnia Agustini, Huda Shalahudin Darusman
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引用次数: 0

摘要

背景:疟疾仍然是全球健康的重大负担,抗药性是控制疟疾的主要挑战。抗疟药物抗药性的出现是疟疾管理中的一个关键问题,因为它增加了与疟疾相关的发病率和死亡率。目的:鉴于疟疾防治中持续存在的挑战,尤其是抗药性的出现,本研究旨在调查硼瑞林和福马吉林的新型联合疗法对瑞士韦伯斯特小鼠感染伯格氏疟原虫的疗效。研究结果将有助于开发新的有效抗疟疗法:本研究采用了一种独特的方法,使用年龄为 6-8 周的瑞士韦伯斯特小鼠,将其分为五组,每组五只。通过对寄生虫血症水平、存活率以及肝脏和脾脏的组织学变化进行综合评估,评价了联合疗法的疗效。这种严格的方法确保了我们研究结果的可靠性和有效性:结果:硼瑞林和氟甲嘧啶联合治疗组的寄生虫血症最低,仅为 5%,而对照组则高达 15%。此外,在感染后第九天,联合用药组的抑制率最高,达到 69.6%。组织病理学改变仅限于窦状扩张、肝细胞气球化和血吸虫素的存在:这些研究结果表明,硼雷利定和福马吉林的组合有望成为一种潜在的抗疟疗法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Antimalarial activity of borrelidin and fumagilin in Plasmodium berghei-infected mice.

Background: Malaria remains a significant global health burden, with drug resistance posing a major challenge to its control. The emergence of resistance to antimalarial drugs represents a critical issue in malaria management, as it heightens the likelihood of morbidity and mortality associated with the disease. There is an urgent requirement for a novel candidate drug with a distinct mechanism of action.

Aim: In light of the ongoing challenges in malaria management, particularly the emergence of drug resistance, this study aimed to investigate the efficacy of a novel combination therapy of borrelidin and fumagilin against Plasmodium berghei infection on Swiss Webster mice. The findings of this study could contribute to developing new and effective antimalarial treatments.

Methods: This study employed a unique approach, using Swiss Webster mice aged 6-8 weeks and dividing them into five groups, each with five mice. The therapeutic efficacy of the combination treatment was evaluated through a comprehensive assessment of parasitemia levels, survival rates, and histological changes in the liver and spleen. This rigorous methodology ensures the reliability and validity of our findings.

Results: The combination of borrelidin and fumagilin led to the lowest parasitemia at 5%, contrasting with the control group reaching 15%. Moreover, the combination group exhibited the highest inhibition rate of 69.6% on day nine post-infection. Histopathological alterations were limited to sinusoid dilation, hepatocyte ballooning, and the presence of hemozoin.

Conclusion: These findings suggest that the combination of borrelidin and fumagilin holds promise as a potential antimalarial therapy.

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来源期刊
Open Veterinary Journal
Open Veterinary Journal VETERINARY SCIENCES-
CiteScore
1.40
自引率
0.00%
发文量
112
审稿时长
12 weeks
期刊介绍: Open Veterinary Journal is a peer-reviewed international open access online and printed journal that publishes high-quality original research articles. reviews, short communications and case reports dedicated to all aspects of veterinary sciences and its related subjects. Research areas include the following: Infectious diseases of zoonotic/food-borne importance, applied biochemistry, parasitology, endocrinology, microbiology, immunology, pathology, pharmacology, physiology, epidemiology, molecular biology, immunogenetics, surgery, ophthalmology, dermatology, oncology and animal reproduction. All papers are peer-reviewed. Moreover, with the presence of well-qualified group of international referees, the process of publication will be done meticulously and to the highest standards.
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