基因与生活方式相互作用对南亚人群代谢疾病相关特征影响的系统性综述。

IF 5.9 2区 医学 Q1 NUTRITION & DIETETICS
Manahil M Bineid, Eduard F Ventura, Aryan Samidoust, Venkatesan Radha, Ranjit Mohan Anjana, Vasudevan Sudha, Gemma E Walton, Viswanathan Mohan, Karani Santhanakrishnan Vimaleswaran
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引用次数: 0

摘要

背景:南亚次区域的最新数据引起了人们对代谢性疾病发病率急剧上升的关注,而代谢性疾病的发病率受遗传和生活方式因素的影响:本系统综述旨在总结基因与生活方式相互作用对该人群代谢结果影响的当代证据:截至 2023 年 3 月,我们在 PubMed、Web of Science 和 SCOPUS 数据库中检索了有关基因变异与饮食和体育锻炼等生活方式因素之间相互作用对肥胖和 2 型糖尿病特征影响的观察性和干预性研究:在提取的 14 783 篇出版物中,有 15 篇被认为符合纳入本研究的条件。数据提取由 3 名研究人员独立完成。使用横断面研究评估工具(AXIS)、非随机干预研究中的偏倚风险(ROBINS-I)和营养遗传学研究的方法质量评分对纳入研究的质量进行评估:数据分析:采用叙事综合法,以文字和表格形式呈现研究结果。来自印度(8 项)、巴基斯坦(3 项)、斯里兰卡(1 项)以及散居在新加坡和加拿大的南亚人(3 项)的研究共报告了 543 项基因与生活方式的相互作用,其中 132 项(24%)具有统计学意义。这些结果与遗传因素与缺乏运动、不良睡眠习惯、吸烟以及碳水化合物、蛋白质和脂肪的膳食摄入相互作用对该人群代谢性疾病风险的影响有关:本系统综述的研究结果提供了南亚人群中基因与生活方式相互作用影响代谢特征的证据。然而,由于缺乏重复和校正多重测试,以及所纳入研究的样本量较小,可能会限制证据的确凿性。注,本文是《营养评论》"精准营养 "特辑的一部分:系统综述注册:PROSPERO 注册号:CRD42023402408。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A Systematic Review of the Effect of Gene-Lifestyle Interactions on Metabolic-Disease-Related Traits in South Asian Populations.

Context: Recent data from the South Asian subregion have raised concern about the dramatic increase in the prevalence of metabolic diseases, which are influenced by genetic and lifestyle factors.

Objective: The aim of this systematic review was to summarize the contemporary evidence for the effect of gene-lifestyle interactions on metabolic outcomes in this population.

Data sources: PubMed, Web of Science, and SCOPUS databases were searched up until March 2023 for observational and intervention studies investigating the interaction between genetic variants and lifestyle factors such as diet and physical activity on obesity and type 2 diabetes traits.

Data extraction: Of the 14 783 publications extracted, 15 were deemed eligible for inclusion in this study. Data extraction was carried out independently by 3 investigators. The quality of the included studies was assessed using the Appraisal Tool for Cross-Sectional Studies (AXIS), the Risk Of Bias In Non-randomized Studies-of Interventions (ROBINS-I), and the methodological quality score for nutrigenetics studies.

Data analysis: Using a narrative synthesis approach, the findings were presented in textual and tabular format. Together, studies from India (n = 8), Pakistan (n = 3), Sri Lanka (n = 1), and the South Asian diaspora in Singapore and Canada (n = 3) reported 543 gene-lifestyle interactions, of which 132 (∼24%) were statistically significant. These results were related to the effects of the interaction of genetic factors with physical inactivity, poor sleep habits, smoking, and dietary intake of carbohydrates, protein, and fat on the risk of metabolic disease in this population.

Conclusions: The findings of this systematic review provide evidence of gene-lifestyle interactions impacting metabolic traits within the South Asian population. However, the lack of replication and correction for multiple testing and the small sample size of the included studies may limit the conclusiveness of the evidence. Note, this paper is part of the Nutrition Reviews Special Collection on Precision Nutrition.

Systematic review registration: PROSPERO registration No. CRD42023402408.

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来源期刊
Nutrition reviews
Nutrition reviews 医学-营养学
CiteScore
12.20
自引率
1.60%
发文量
121
审稿时长
6-12 weeks
期刊介绍: Nutrition Reviews is a highly cited, monthly, international, peer-reviewed journal that specializes in the publication of authoritative and critical literature reviews on current and emerging topics in nutrition science, food science, clinical nutrition, and nutrition policy. Readers of Nutrition Reviews include nutrition scientists, biomedical researchers, clinical and dietetic practitioners, and advanced students of nutrition.
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