子宫内膜异位症与非子宫内膜异位症体外受精怀孕时间的比较。

IF 1.6 Q3 OBSTETRICS & GYNECOLOGY
Obstetrics and Gynecology International Pub Date : 2024-09-06 eCollection Date: 2024-01-01 DOI:10.1155/2024/4139821
Hartanto Bayuaji, Artha Falentin Putri Susilo, Kevin Dominique Tjandraprawira
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引用次数: 0

摘要

研究背景本研究旨在比较接受体外受精(IVF)的子宫内膜异位症患者和非子宫内膜异位症患者的妊娠时间(TTP)。我们纳入了2014年1月1日至2020年3月31日期间获得生化妊娠的291名患者(53名子宫内膜异位症患者和238名非子宫内膜异位症患者),无论是单胎还是多胎(血清β-hCG >5 mIU/mL)。我们排除了病例记录不完整的患者和拒绝参与的患者。怀孕时间是指从确定不孕到确认生化妊娠的时间间隔,以月为单位。子宫内膜异位症诊断包括经手术确诊的任何形式的子宫内膜异位症。统计分析采用 Mann-Whitney U 检验。通过 Kaplan-Meier 检验对怀孕时间进行评估。P 值 结果子宫内膜异位症患者的不孕时间较短(4 年对 5 年,P=0.024)。两组患者发病时的中位年龄和体重指数相似。子宫内膜异位症组和非子宫内膜异位症组的 TTP 无明显差异(57.7 个月 vs. 70.9 个月,P=0.060),Cox 回归检验进一步证实了这一点,该检验纳入了混杂因素(IVF 方案(OR:1.482,95% CI 0.667-3.292,P=0.334)和周期类型(OR 1.071,95% CI 0.803-1.430,P=0.640))。子宫内膜异位症组在确诊不孕后约 169 个月达到最高累积妊娠率,而非子宫内膜异位症组在确诊不孕后约 255 个月达到最高累积妊娠率:结论:子宫内膜异位症和非子宫内膜异位症患者的怀孕时间没有明显差异。结论:子宫内膜异位症和非子宫内膜异位症患者的怀孕时间没有明显差异,但子宫内膜异位症患者的不孕时间往往较短。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Comparison of Time to Pregnancy in In Vitro Fertilisation between Endometriosis and Nonendometriosis.

Background: This study is to compare the time to pregnancy (TTP) between patients with endometriosis and nonendometriosis undergoing in vitro fertilisation (IVF).Material and Methods.This is an observational retrospective cohort study. We included 291 patients (53 with endometriosis and 238 without endometriosis) achieving biochemical pregnancy, whether singleton or multifetal (serum beta-hCG >5 mIU/mL), between 1st January 2014 and 31st March 2020. We excluded patients with incomplete case notes and those declining participation. Time to pregnancy is the interval between the time when infertility was established to the date of confirmed biochemical pregnancy, expressed in months. Endometriosis diagnosis includes any form of endometriosis through surgical confirmation. A statistical analysis was done through the Mann-Whitney U test. Time to pregnancy was assessed through the Kaplan-Meier test. A p value <0.05 is considered statistically significant.

Results: Endometriosis patients had a shorter infertility duration (4 years vs. 5 years, p=0.024). Both groups had similar median age and body mass index at presentation. There was no significant difference in the TTP between endometriosis and nonendometriosis groups (57.7 vs. 70.9 months, p=0.060), further confirmed by a Cox regression test incorporating confounders (IVF protocol (OR: 1.482, 95% CI 0.667-3.292, and p=0.334) and type of the cycle (OR 1.071, 95% CI 0.803-1.430, and p=0.640)). The endometriosis group reached the maximum cumulative pregnancy rate at around 169 months postinfertility diagnosis, whilst the nonendometriosis group at around 255 months postinfertility diagnosis.

Conclusion: Time to pregnancy between endometriosis and nonendometriosis is not significantly different. However, infertility among patients with endometriosis tends to be shorter.

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来源期刊
Obstetrics and Gynecology International
Obstetrics and Gynecology International OBSTETRICS & GYNECOLOGY-
CiteScore
3.60
自引率
0.00%
发文量
26
审稿时长
19 weeks
期刊介绍: Obstetrics and Gynecology International is a peer-reviewed, Open Access journal that aims to provide a forum for scientists and clinical professionals working in obstetrics and gynecology. The journal publishes original research articles, review articles, and clinical studies related to obstetrics, maternal-fetal medicine, general gynecology, gynecologic oncology, uro-gynecology, reproductive medicine and infertility, reproductive endocrinology, and sexual medicine.
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