比较高强度间歇运动和自愿运动训练对大鼠认知功能的影响

IF 2.5 4区医学 Q3 NEUROSCIENCES

Neuroscience Letters Pub Date : 2024-09-19 DOI:10.1016/j.neulet.2024.137993

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引用次数: 0

摘要

众所周知，运动能提高负责学习和记忆的大脑区域海马体中的脑源性神经营养因子（BDNF）水平，从而改善认知功能和学习过程。不过，据称不同类型的运动会在大脑中引起不同的反应。有人认为，运动时分泌的乳酸盐和骨钙素与 BDNF 水平的增加有关。然而，关于这一主题的研究还不够多。本研究旨在比较高强度间歇训练（HIIT）和自愿运动训练对认知能力和分子连接的影响。雄性大鼠被随机分为对照组、自愿运动训练组和高强度间歇训练组。自愿运动组在8周内可自由使用自愿轮。HIIT组每周3天在跑步机上进行HIIT训练，为期8周。大鼠在最后一次运动训练 24 小时后接受空地（OF）、高架迷宫（EPM）和莫里斯水迷宫（MWM）测试。在麻醉下抽血后，大鼠被处死并分离海马组织。通过酶联免疫吸附试验（ELISA）评估血液中糖皮质激素和BDNF的水平，通过实时定量反转录聚合酶链反应（RT-PCR）评估海马中骨钙素和BDNF的表达。自愿运动训练和HIIT均未对通过OF、EPM和MWM测试评估的行为参数产生显著影响。然而，HIIT组海马组织中BDNF的表达高于对照组。此外，HIIT 组和自愿运动组海马组织中骨钙素的表达高于对照组。总之，根据我们的研究结果，虽然 HIIT 对认知功能没有显著影响，但它对大脑功能的影响似乎比自愿运动更有效。

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Comparing the effect of high-intensity interval exercise and voluntary exercise training on cognitive functions in rats

It is known that exercise increases brain-derived neurotrophic factor (BDNF) levels in the hippocampus, the brain region responsible for learning and memory, resulting in improved cognitive functions and learning processes. However, it is claimed that different types of exercise cause different responses in the brain. It is thought that lactate and osteocalcin secreted in response to exercise are associated with an increase in BDNF levels. However, there are not enough studies on this subject. This study aimed to compare the effects of high-intensity interval training (HIIT) and voluntary exercise training on cognitive performance and molecular connections. Male rats were randomly divided into control, voluntary exercise training and HIIT groups. The voluntary exercise group had free access to the voluntary wheel for 8 weeks. The HIIT group performed HIIT on the treadmill 3 days a week for 8 weeks. The rats underwent open field (OF), elevated plus maze (EPM) and Morris water maze (MWM) tests 24 h after the last exercise training. Then, after blood was drawn under anesthesia, the rats were sacrificed and their hippocampus tissues were separated. Glucocorticoid and BDNF levels in the blood were evaluated by enzyme-linked immunosorbent assay (ELISA), and osteocalcin and BDNF expressions in the hippocampus were evaluated by real-time quantitative reverse transcription-polymerase chain reaction (RT-PCR). Neither voluntary exercise training nor HIIT had any significant effect on behavioral parameters assessed by OF, EPM and MWM tests. However, BDNF expression in hippocampus tissue was higher in the HIIT group than in the control group. In addition, osteocalcin expression in hippocampus tissue was higher in the HIIT and voluntary exercise groups than in the control group. In conclusion, according to the findings we obtained from this study, although it does not have a significant effect on cognitive functions, the effect of HIIT on brain functions seems to be more effective than voluntary exercise.

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来源期刊

Neuroscience Letters 医学-神经科学

CiteScore

5.20

自引率

0.00%

发文量

408

审稿时长

50 days

期刊介绍： Neuroscience Letters is devoted to the rapid publication of short, high-quality papers of interest to the broad community of neuroscientists. Only papers which will make a significant addition to the literature in the field will be published. Papers in all areas of neuroscience - molecular, cellular, developmental, systems, behavioral and cognitive, as well as computational - will be considered for publication. Submission of laboratory investigations that shed light on disease mechanisms is encouraged. Special Issues, edited by Guest Editors to cover new and rapidly-moving areas, will include invited mini-reviews. Occasional mini-reviews in especially timely areas will be considered for publication, without invitation, outside of Special Issues; these un-solicited mini-reviews can be submitted without invitation but must be of very high quality. Clinical studies will also be published if they provide new information about organization or actions of the nervous system, or provide new insights into the neurobiology of disease. NSL does not publish case reports.