小 GTP 酶在心肌肥大中的作用（综述）。

IF 3.4 3区医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL

Molecular medicine reports Pub Date : 2024-11-01 Epub Date: 2024-09-20 DOI:10.3892/mmr.2024.13332

Xin Wang, Xinwen Nie, Hao Wang, Zhanhong Ren

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引用次数: 0

摘要

心脏肥大是心脏对各种病理刺激做出反应和适应的结果，其持续发展是导致心力衰竭的一个主要因素。然而，心脏肥大的分子机制仍不清楚。Ras、Rho、Rab、Arf 和 Ran 亚家族中的小 GTP 酶具有 GTP 酶活性，在调节各种细胞反应中发挥着关键作用。以往的研究表明，Ras、Rho 和 Rab 与心脏肥大密切相关，它们的过表达可诱导心脏肥大。在此，我们回顾了小 GTP 酶在心肌肥厚中的功能，并为预防和治疗心肌肥厚提供更多的见解和参考。

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Roles of small GTPases in cardiac hypertrophy (Review).

Cardiac hypertrophy results from the heart reacting and adapting to various pathological stimuli and its persistent development is a major contributing factor to heart failure. However, the molecular mechanisms of cardiac hypertrophy remain unclear. Small GTPases in the Ras, Rho, Rab, Arf and Ran subfamilies exhibit GTPase activity and play crucial roles in regulating various cellular responses. Previous studies have shown that Ras, Rho and Rab are closely linked to cardiac hypertrophy and that their overexpression can induce cardiac hypertrophy. Here, we review the functions of small GTPases in cardiac hypertrophy and provide additional insights and references for the prevention and treatment of cardiac hypertrophy.

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来源期刊

Molecular medicine reports 医学-病理学

CiteScore

7.60

自引率

0.00%

发文量

321

审稿时长

1.5 months

期刊介绍： Molecular Medicine Reports is a monthly, peer-reviewed journal available in print and online, that includes studies devoted to molecular medicine, underscoring aspects including pharmacology, pathology, genetics, neurosciences, infectious diseases, molecular cardiology and molecular surgery. In vitro and in vivo studies of experimental model systems pertaining to the mechanisms of a variety of diseases offer researchers the necessary tools and knowledge with which to aid the diagnosis and treatment of human diseases.