{"title":"印度重症监护室网络中的念珠菌血症和中央管路相关念珠菌血症：COVID-19 大流行的影响。","authors":"Purva Mathur, Sharad Srivastav, Arpan Kumar Thakur, Rasna Parveen, Mamta Puraswani, Ashish Kumar Srivastava, Arunaloke Chakrabarti, Camilla Rodrigues, Veeraraghavan Balaji, Pallab Ray, Manisha Biswal, Chand Wattal, Vimala Venkatesh, Nandini Sethuraman, Sanjay Bhattacharya, Vijaya Lakshmi Nag, Vibhor Tak, Bijayini Behera, Neeraj Goel, Jyoti Iravane, Sudipta Mukherjee, Raja Ray, Sanjeev K Singh, Chiranjay Mukhopadhyay, Joy Sarojini Michael, Bashir Ahmad Fomda, Juliah Chelliah, Anjali Shetty, Tadepalli Karuna, Aparna Ningombam, Subodh Kumar, Kapil Dev Soni, Sushma Sagar, Richa Aggrawal, Deepak Gupta, Gyaninder Pal Singh, Ashish Bindra, Kamran Farooque, Shashank Purwar, Sagar Khadanga, K E Vandana, Muralidhar Varma, Vijayshri Deotale, Padma Das, Ruchita Lohiya, Amber Prasad, Puneet Kumar Gupta, Balram Ji Omar, Ankit Aggarwal, Sherish Baqal, Khuraijam Ranjana Devi, L Chaoba Singh, Soumyadip Chatterji, Gaurav Goel, Satyam Mukherjee, Yamunadevi V Ramanathan, Aparna Sonowal, Prachi Verma, Ashoka Mahapatra, Vinaykumar Hallur, Ujjwala Nitin Gaikwad, Anudita Bhargava, Kanne Padmaja, Nagari Bheerappa, Vidhi Jain, Pradeep Bhatia, Kuldeep Singh, Daisy Khera, Neeraj Gupta, Hema Paul, Sheetal Verma, Zia Arshad, Ratinder Jhaj, Shikha Malik, M A Thirunarayan, Hirak Jyoti Raj, Prashant Gupta, Dandu Himanshu, Shivaprakash M Rudramurthy, Reema Nath, Renu Gur, Nari M Lyngdoh, Clarissa Lyngdoh, Sheela Devi, Shalini Malhotra, Rajni Gaind, Rushika Saksena, Rajni Sharma, Kamini Walia","doi":"10.1111/myc.13790","DOIUrl":null,"url":null,"abstract":"<p><strong>Background and objectives: </strong>Candidaemia is a potentially life-threatening emergency in the intensive care units (ICUs). Surveillance using common protocols in a large network of hospitals would give meaningful estimates of the burden of candidaemia and central line associated candidaemia in low resource settings. We undertook this study to understand the burden and epidemiology of candidaemia in multiple ICUs of India, leveraging the previously established healthcare-associated infections (HAI) surveillance network. Our aim was also to assess the impact that the pandemic of COVID-19 had on the rates and associated mortality of candidaemia.</p><p><strong>Methods: </strong>This study included adult patients from 67 Indian ICUs in the AIIMS-HAI surveillance network that conducted BSI surveillance in COVID-19 and non-COVID-19 ICUs during and before the COVID-19 pandemic periods. Hospitals identified healthcare-associated candidaemia and central line associated candidaemia and reported clinical and microbiological data to the network as per established and previously published protocols.</p><p><strong>Results: </strong>A total of 401,601 patient days and 126,051 central line days were reported during the study period. A total of 377 events of candidaemia were recorded. The overall rate of candidaemia in our network was 0.93/1000 patient days. The rate of candidaemia in COVID-19 ICUs (2.52/1000 patient days) was significantly higher than in non-COVID-19 ICUs (1.05/patient days) during the pandemic period. The rate of central line associated candidaemia in COVID-19 ICUs (4.53/1000 central line days) was also significantly higher than in non-COVID-19 ICUs (1.73/1000 central line days) during the pandemic period. Mortality in COVID-19 ICUs associated with candidaemia (61%) was higher than that in non-COVID-19 ICUs (41%). A total of 435 Candida spp. were isolated. C. tropicalis (26.7%) was the most common species. C. auris accounted for 17.5% of all isolates and had a high mortality.</p><p><strong>Conclusion: </strong>Patients in ICUs with COVID-19 infections have a much higher risk of candidaemia, CLAC and its associated mortality. Network level data helps in understanding the true burden of candidaemia and will help in framing infection control policies for the country.</p>","PeriodicalId":18797,"journal":{"name":"Mycoses","volume":"67 9","pages":"e13790"},"PeriodicalIF":4.1000,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Candidaemia and Central Line-Associated Candidaemia in a Network of Indian ICUs: Impact of COVID-19 Pandemic.\",\"authors\":\"Purva Mathur, Sharad Srivastav, Arpan Kumar Thakur, Rasna Parveen, Mamta Puraswani, Ashish Kumar Srivastava, Arunaloke Chakrabarti, Camilla Rodrigues, Veeraraghavan Balaji, Pallab Ray, Manisha Biswal, Chand Wattal, Vimala Venkatesh, Nandini Sethuraman, Sanjay Bhattacharya, Vijaya Lakshmi Nag, Vibhor Tak, Bijayini Behera, Neeraj Goel, Jyoti Iravane, Sudipta Mukherjee, Raja Ray, Sanjeev K Singh, Chiranjay Mukhopadhyay, Joy Sarojini Michael, Bashir Ahmad Fomda, Juliah Chelliah, Anjali Shetty, Tadepalli Karuna, Aparna Ningombam, Subodh Kumar, Kapil Dev Soni, Sushma Sagar, Richa Aggrawal, Deepak Gupta, Gyaninder Pal Singh, Ashish Bindra, Kamran Farooque, Shashank Purwar, Sagar Khadanga, K E Vandana, Muralidhar Varma, Vijayshri Deotale, Padma Das, Ruchita Lohiya, Amber Prasad, Puneet Kumar Gupta, Balram Ji Omar, Ankit Aggarwal, Sherish Baqal, Khuraijam Ranjana Devi, L Chaoba Singh, Soumyadip Chatterji, Gaurav Goel, Satyam Mukherjee, Yamunadevi V Ramanathan, Aparna Sonowal, Prachi Verma, Ashoka Mahapatra, Vinaykumar Hallur, Ujjwala Nitin Gaikwad, Anudita Bhargava, Kanne Padmaja, Nagari Bheerappa, Vidhi Jain, Pradeep Bhatia, Kuldeep Singh, Daisy Khera, Neeraj Gupta, Hema Paul, Sheetal Verma, Zia Arshad, Ratinder Jhaj, Shikha Malik, M A Thirunarayan, Hirak Jyoti Raj, Prashant Gupta, Dandu Himanshu, Shivaprakash M Rudramurthy, Reema Nath, Renu Gur, Nari M Lyngdoh, Clarissa Lyngdoh, Sheela Devi, Shalini Malhotra, Rajni Gaind, Rushika Saksena, Rajni Sharma, Kamini Walia\",\"doi\":\"10.1111/myc.13790\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background and objectives: </strong>Candidaemia is a potentially life-threatening emergency in the intensive care units (ICUs). Surveillance using common protocols in a large network of hospitals would give meaningful estimates of the burden of candidaemia and central line associated candidaemia in low resource settings. We undertook this study to understand the burden and epidemiology of candidaemia in multiple ICUs of India, leveraging the previously established healthcare-associated infections (HAI) surveillance network. Our aim was also to assess the impact that the pandemic of COVID-19 had on the rates and associated mortality of candidaemia.</p><p><strong>Methods: </strong>This study included adult patients from 67 Indian ICUs in the AIIMS-HAI surveillance network that conducted BSI surveillance in COVID-19 and non-COVID-19 ICUs during and before the COVID-19 pandemic periods. Hospitals identified healthcare-associated candidaemia and central line associated candidaemia and reported clinical and microbiological data to the network as per established and previously published protocols.</p><p><strong>Results: </strong>A total of 401,601 patient days and 126,051 central line days were reported during the study period. A total of 377 events of candidaemia were recorded. The overall rate of candidaemia in our network was 0.93/1000 patient days. The rate of candidaemia in COVID-19 ICUs (2.52/1000 patient days) was significantly higher than in non-COVID-19 ICUs (1.05/patient days) during the pandemic period. The rate of central line associated candidaemia in COVID-19 ICUs (4.53/1000 central line days) was also significantly higher than in non-COVID-19 ICUs (1.73/1000 central line days) during the pandemic period. Mortality in COVID-19 ICUs associated with candidaemia (61%) was higher than that in non-COVID-19 ICUs (41%). A total of 435 Candida spp. were isolated. C. tropicalis (26.7%) was the most common species. C. auris accounted for 17.5% of all isolates and had a high mortality.</p><p><strong>Conclusion: </strong>Patients in ICUs with COVID-19 infections have a much higher risk of candidaemia, CLAC and its associated mortality. Network level data helps in understanding the true burden of candidaemia and will help in framing infection control policies for the country.</p>\",\"PeriodicalId\":18797,\"journal\":{\"name\":\"Mycoses\",\"volume\":\"67 9\",\"pages\":\"e13790\"},\"PeriodicalIF\":4.1000,\"publicationDate\":\"2024-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Mycoses\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1111/myc.13790\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"DERMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Mycoses","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1111/myc.13790","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"DERMATOLOGY","Score":null,"Total":0}
Candidaemia and Central Line-Associated Candidaemia in a Network of Indian ICUs: Impact of COVID-19 Pandemic.
Background and objectives: Candidaemia is a potentially life-threatening emergency in the intensive care units (ICUs). Surveillance using common protocols in a large network of hospitals would give meaningful estimates of the burden of candidaemia and central line associated candidaemia in low resource settings. We undertook this study to understand the burden and epidemiology of candidaemia in multiple ICUs of India, leveraging the previously established healthcare-associated infections (HAI) surveillance network. Our aim was also to assess the impact that the pandemic of COVID-19 had on the rates and associated mortality of candidaemia.
Methods: This study included adult patients from 67 Indian ICUs in the AIIMS-HAI surveillance network that conducted BSI surveillance in COVID-19 and non-COVID-19 ICUs during and before the COVID-19 pandemic periods. Hospitals identified healthcare-associated candidaemia and central line associated candidaemia and reported clinical and microbiological data to the network as per established and previously published protocols.
Results: A total of 401,601 patient days and 126,051 central line days were reported during the study period. A total of 377 events of candidaemia were recorded. The overall rate of candidaemia in our network was 0.93/1000 patient days. The rate of candidaemia in COVID-19 ICUs (2.52/1000 patient days) was significantly higher than in non-COVID-19 ICUs (1.05/patient days) during the pandemic period. The rate of central line associated candidaemia in COVID-19 ICUs (4.53/1000 central line days) was also significantly higher than in non-COVID-19 ICUs (1.73/1000 central line days) during the pandemic period. Mortality in COVID-19 ICUs associated with candidaemia (61%) was higher than that in non-COVID-19 ICUs (41%). A total of 435 Candida spp. were isolated. C. tropicalis (26.7%) was the most common species. C. auris accounted for 17.5% of all isolates and had a high mortality.
Conclusion: Patients in ICUs with COVID-19 infections have a much higher risk of candidaemia, CLAC and its associated mortality. Network level data helps in understanding the true burden of candidaemia and will help in framing infection control policies for the country.
期刊介绍：
The journal Mycoses provides an international forum for original papers in English on the pathogenesis, diagnosis, therapy, prophylaxis, and epidemiology of fungal infectious diseases in humans as well as on the biology of pathogenic fungi.
Medical mycology as part of medical microbiology is advancing rapidly. Effective therapeutic strategies are already available in chemotherapy and are being further developed. Their application requires reliable laboratory diagnostic techniques, which, in turn, result from mycological basic research. Opportunistic mycoses vary greatly in their clinical and pathological symptoms, because the underlying disease of a patient at risk decisively determines their symptomatology and progress. The journal Mycoses is therefore of interest to scientists in fundamental mycological research, mycological laboratory diagnosticians and clinicians interested in fungal infections.
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