将尼罗罗非鱼(oreochromis niloticus)皮肤作为异种移植用于动物物种的新方法。

IF 0.7 4区 农林科学 Q3 VETERINARY SCIENCES
Tamara Qabazard, Husain Al-Sayegh
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引用次数: 0

摘要

尼罗罗非鱼(Oreochromis niloticus)鱼皮在人类和兽医学中越来越多地被用于治疗烧伤创面的异种移植。本研究的目的是以巴西专利(WO2017/035615 A1)为指导,自行制备移植物,并将其应用于动物物种(n = 4)的全厚伤口。这些伤口都是真皮层全部缺失的污染性伤口,之前都曾进行过手术清创,并采用传统的伤口愈合技术进行治疗,但均未取得成功。这种移植技术就是针对治疗效果不佳而开发的。准备好移植物后,将其缝合到患处,使所有病例的伤口完全收缩并上皮化。由于伤口污染严重,患者同时需使用一个疗程的全身抗生素。不同鱼种更换敷料的频率不同,但没有明显的不良反应。这种处理尼罗罗非鱼鱼皮的方法证明很有希望用于受污染的伤口,因为这种方法成本低廉,易于获取和开发,由于减少了更换敷料的频率和处理方式,减轻了野生动物患者的压力,而且可以在临床环境中使用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
NOVEL USE OF NILE TILAPIA FISH (OREOCHROMIS NILOTICUS) SKIN AS XENOGRAFT IN ZOOLOGICAL SPECIES.

Nile tilapia fish skin (Oreochromis niloticus) has been increasingly used in human and veterinary medicine in xenografts for treatment of burn wounds. The objective of this study was to self-prepare the graft using a Brazilian patent (WO2017/035615 A1) as a guide and apply it to full-thickness wounds in zoological species (n = 4). The wounds, which were all characterized as contaminated wounds in which the entire dermal layer was missing, had all previously been surgically debrided and treated with traditional wound-healing techniques without success. This graft technique was developed in response to the poor treatment success. The graft was prepared and sutured to the affected area, leading to complete contraction and epithelialization in all cases. The patients were concurrently placed on one course of systemic antibiotics because of the severity of wound contamination. The frequency of dressing changes varied between species and no adverse effects were apparent. This method of processing Nile tilapia fish skin proves promising for use in contaminated wounds, as it is inexpensive and easy to acquire and develop, mitigates stress in wildlife patients because of a decreased frequency of dressing changes and therefore handling, and can be utilized in clinical environments.

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来源期刊
Journal of Zoo and Wildlife Medicine
Journal of Zoo and Wildlife Medicine 农林科学-兽医学
CiteScore
1.70
自引率
14.30%
发文量
74
审稿时长
9-24 weeks
期刊介绍: The Journal of Zoo and Wildlife Medicine (JZWM) is considered one of the major sources of information on the biology and veterinary aspects in the field. It stems from the founding premise of AAZV to share zoo animal medicine experiences. The Journal evolved from the long history of members producing case reports and the increased publication of free-ranging wildlife papers. The Journal accepts manuscripts of original research findings, case reports in the field of veterinary medicine dealing with captive and free-ranging wild animals, brief communications regarding clinical or research observations that may warrant publication. It also publishes and encourages submission of relevant editorials, reviews, special reports, clinical challenges, abstracts of selected articles and book reviews. The Journal is published quarterly, is peer reviewed, is indexed by the major abstracting services, and is international in scope and distribution. Areas of interest include clinical medicine, surgery, anatomy, radiology, physiology, reproduction, nutrition, parasitology, microbiology, immunology, pathology (including infectious diseases and clinical pathology), toxicology, pharmacology, and epidemiology.
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