使用丁羟吗啡、氮杂哌啶酮和美托咪定对黑吼猴(alouatta pigra)进行非侵入性固定是安全有效的。

IF 0.7 4区 农林科学 Q3 VETERINARY SCIENCES
Stephanie C Dantino, Andrew C Cushing, Shawna Hawkins, Celso Poot, Julie Sheldon
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引用次数: 0

摘要

使用丁吗啡酚、氮杂哌隆和美托咪定(BAM)对黑吼猴(Alouatta pigra)进行固定的方法以前从未报道过。在这项观察性研究中,10 只人工饲养的黑吼猴被注射了 0.02 毫升/千克的复方 BAM(丁吗啉 27.3 毫克/毫升、阿扎哌隆 9.1 毫克/毫升、美托咪定 10.9 毫克/毫升)。记录固定时间,进行动脉血气检查,并每隔 5 分钟测量心率、呼吸频率、示波动脉血压、SPO2 和直肠温度。手术完成后,给患者注射纳曲酮和阿替帕唑,并记录恢复时间。如果需要进行手术等侵入性程序并需要额外用药,则从数据分析中删除该患者的进一步数据。BAM 的最终剂量为 0.55 ± 0.12 mg/kg 丁吗啡诺、0.19 ± 0.04 mg/kg 阿扎哌隆和 0.22 ± 0.05 mg/kg 美托咪定。10 只猴子中有 9 只在 4 ± 2 分钟内达到镇静状态,可以进行体格检查、静脉穿刺和结核菌素皮肤测试。没有猴子达到可以插管的固定平面。该物种的生理变量是可以接受的。通过脉搏血氧仪观察到三只猴子出现低氧血症(SPO2 < 95%),动脉血气观察到正常氧血症。恢复顺利且迅速。因此,BAM 是黑吼猴进行无创手术或麻醉诱导前的一种可行选择。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
IMMOBILIZATION OF BLACK HOWLER MONKEYS (ALOUATTA PIGRA) USING BUTORPHANOL, AZAPERONE, MEDETOMIDINE IS SAFE AND EFFECTIVE FOR NONINVASIVE PROCEDURES.

Administration of butorphanol, azaperone, and medetomidine (BAM) for immobilization of black howler monkeys (Alouatta pigra) has not been previously reported. In this observational study, 0.02 ml/kg of compounded BAM (butorphanol 27.3 mg/ml, azaperone 9.1 mg/ml, medetomidine 10.9 mg/ml) was administered IM in 10 captive black howler monkeys. Time to immobilization was recorded, an arterial blood gas performed, and at 5-min intervals, HR, RR, oscillometric arterial blood pressure, SPO2, and rectal temperature were measured. Naltrexone and atipamezole were administered IM at procedure completion and recovery times were recorded. If invasive procedures such as surgery were necessary and additional drugs needed, further data from that individual was removed from data analysis. Final BAM dosages were 0.55 ± 0.12 mg/kg butorphanol, 0.19 ± 0.04 mg/kg azaperone, and 0.22 ± 0.05 mg/kg medetomidine. Nine of 10 monkeys achieved sedation allowing for physical exam, venipuncture, and tuberculin skin testing within 4 ± 2 min. No monkeys reached a plane of immobilization allowing for intubation. Physiologic variables were acceptable for this species. Hypoxemia (SPO2 < 95%) was observed in three monkeys via pulse oximetry, and normoxemia was observed on arterial blood gas. Recovery was smooth and rapid. Therefore, BAM is a viable option for noninvasive procedures or as a premedication prior to induction of anesthesia in black howler monkeys.

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来源期刊
Journal of Zoo and Wildlife Medicine
Journal of Zoo and Wildlife Medicine 农林科学-兽医学
CiteScore
1.70
自引率
14.30%
发文量
74
审稿时长
9-24 weeks
期刊介绍: The Journal of Zoo and Wildlife Medicine (JZWM) is considered one of the major sources of information on the biology and veterinary aspects in the field. It stems from the founding premise of AAZV to share zoo animal medicine experiences. The Journal evolved from the long history of members producing case reports and the increased publication of free-ranging wildlife papers. The Journal accepts manuscripts of original research findings, case reports in the field of veterinary medicine dealing with captive and free-ranging wild animals, brief communications regarding clinical or research observations that may warrant publication. It also publishes and encourages submission of relevant editorials, reviews, special reports, clinical challenges, abstracts of selected articles and book reviews. The Journal is published quarterly, is peer reviewed, is indexed by the major abstracting services, and is international in scope and distribution. Areas of interest include clinical medicine, surgery, anatomy, radiology, physiology, reproduction, nutrition, parasitology, microbiology, immunology, pathology (including infectious diseases and clinical pathology), toxicology, pharmacology, and epidemiology.
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