Junyu Qu, Rui Zhu, Yongsheng Wu, Guihua Xu, Dawei Wang
{"title":"进行性核上性麻痹的结构-功能耦合异常和脑网络拓扑的核磁共振成像改变","authors":"Junyu Qu, Rui Zhu, Yongsheng Wu, Guihua Xu, Dawei Wang","doi":"10.1002/jmri.29620","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Progressive supranuclear palsy (PSP) can cause structural and functional brain reconstruction. There is a lack of knowledge about the consistency between structural-functional (S-F) connection networks in PSP, despite growing evidence of anomalies in various single brain network parameters.</p><p><strong>Purpose: </strong>To study the changes in the structural and functional networks of PSP, network's topological properties including degree, and the consistency of S-F coupling. The relationship with clinical scales was examined including the assessment of PSP severity, and so on.</p><p><strong>Study type: </strong>Retrospective.</p><p><strong>Subjects: </strong>A total of 51 PSP patients (70.04 ± 7.46, 25 females) and 101 healthy controls (64.58 ± 8.84, 58 females).</p><p><strong>Field strength/sequence: </strong>3-T, resting-state functional MRI, diffusion tensor imaging, and T1-weighted images.</p><p><strong>Assessment: </strong>A graph-theoretic approach was used to evaluate structural and functional network topology metrics. We used the S-F coupling changes to explore the consistency of structural and functional networks.</p><p><strong>Statistical tests: </strong>Independent samples t tests were employed for continuous variables, χ<sup>2</sup> tests were used for categorical variables. For network analysis, two-sample t tests was used and implied an false discovery rate (FDR) correction. Pearson correlation analysis was used to explore the correlations. A P-value <0.05 was considered statistically significant.</p><p><strong>Results: </strong>PSP showed variations within and between modules. Specifically, PSP had decreased network properties changes (t = -2.0136; t = 2.5409; t = -2.5338; t = -2.4296; t = -2.5338; t = 2.8079). PSP showed a lower coupling in the thalamus and left putamen and a higher coupling in the visual, somatomotor, dorsal attention, and ventral attention network. S-F coupling was related to the number of network connections (r = 0.32, r = 0.22) and information transmission efficiency (r = 0.55, r = 0.28). S-F coupling was related to basic academic ability (r = 0.39) and disinhibition (r = 0.49).</p><p><strong>Data conclusion: </strong>PSP may show abnormal S-F coupling and intramodular and intermodular connectome in the structural and functional networks.</p><p><strong>Level of evidence: </strong>3 TECHNICAL EFFICACY: Stage 3.</p>","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.3000,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Abnormal Structural-Functional Coupling and MRI Alterations of Brain Network Topology in Progressive Supranuclear Palsy.\",\"authors\":\"Junyu Qu, Rui Zhu, Yongsheng Wu, Guihua Xu, Dawei Wang\",\"doi\":\"10.1002/jmri.29620\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Progressive supranuclear palsy (PSP) can cause structural and functional brain reconstruction. There is a lack of knowledge about the consistency between structural-functional (S-F) connection networks in PSP, despite growing evidence of anomalies in various single brain network parameters.</p><p><strong>Purpose: </strong>To study the changes in the structural and functional networks of PSP, network's topological properties including degree, and the consistency of S-F coupling. The relationship with clinical scales was examined including the assessment of PSP severity, and so on.</p><p><strong>Study type: </strong>Retrospective.</p><p><strong>Subjects: </strong>A total of 51 PSP patients (70.04 ± 7.46, 25 females) and 101 healthy controls (64.58 ± 8.84, 58 females).</p><p><strong>Field strength/sequence: </strong>3-T, resting-state functional MRI, diffusion tensor imaging, and T1-weighted images.</p><p><strong>Assessment: </strong>A graph-theoretic approach was used to evaluate structural and functional network topology metrics. We used the S-F coupling changes to explore the consistency of structural and functional networks.</p><p><strong>Statistical tests: </strong>Independent samples t tests were employed for continuous variables, χ<sup>2</sup> tests were used for categorical variables. For network analysis, two-sample t tests was used and implied an false discovery rate (FDR) correction. Pearson correlation analysis was used to explore the correlations. A P-value <0.05 was considered statistically significant.</p><p><strong>Results: </strong>PSP showed variations within and between modules. Specifically, PSP had decreased network properties changes (t = -2.0136; t = 2.5409; t = -2.5338; t = -2.4296; t = -2.5338; t = 2.8079). PSP showed a lower coupling in the thalamus and left putamen and a higher coupling in the visual, somatomotor, dorsal attention, and ventral attention network. S-F coupling was related to the number of network connections (r = 0.32, r = 0.22) and information transmission efficiency (r = 0.55, r = 0.28). S-F coupling was related to basic academic ability (r = 0.39) and disinhibition (r = 0.49).</p><p><strong>Data conclusion: </strong>PSP may show abnormal S-F coupling and intramodular and intermodular connectome in the structural and functional networks.</p><p><strong>Level of evidence: </strong>3 TECHNICAL EFFICACY: Stage 3.</p>\",\"PeriodicalId\":16140,\"journal\":{\"name\":\"Journal of Magnetic Resonance Imaging\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":3.3000,\"publicationDate\":\"2024-09-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Magnetic Resonance Imaging\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1002/jmri.29620\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Magnetic Resonance Imaging","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/jmri.29620","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
Abnormal Structural-Functional Coupling and MRI Alterations of Brain Network Topology in Progressive Supranuclear Palsy.
Background: Progressive supranuclear palsy (PSP) can cause structural and functional brain reconstruction. There is a lack of knowledge about the consistency between structural-functional (S-F) connection networks in PSP, despite growing evidence of anomalies in various single brain network parameters.
Purpose: To study the changes in the structural and functional networks of PSP, network's topological properties including degree, and the consistency of S-F coupling. The relationship with clinical scales was examined including the assessment of PSP severity, and so on.
Study type: Retrospective.
Subjects: A total of 51 PSP patients (70.04 ± 7.46, 25 females) and 101 healthy controls (64.58 ± 8.84, 58 females).
Field strength/sequence: 3-T, resting-state functional MRI, diffusion tensor imaging, and T1-weighted images.
Assessment: A graph-theoretic approach was used to evaluate structural and functional network topology metrics. We used the S-F coupling changes to explore the consistency of structural and functional networks.
Statistical tests: Independent samples t tests were employed for continuous variables, χ2 tests were used for categorical variables. For network analysis, two-sample t tests was used and implied an false discovery rate (FDR) correction. Pearson correlation analysis was used to explore the correlations. A P-value <0.05 was considered statistically significant.
Results: PSP showed variations within and between modules. Specifically, PSP had decreased network properties changes (t = -2.0136; t = 2.5409; t = -2.5338; t = -2.4296; t = -2.5338; t = 2.8079). PSP showed a lower coupling in the thalamus and left putamen and a higher coupling in the visual, somatomotor, dorsal attention, and ventral attention network. S-F coupling was related to the number of network connections (r = 0.32, r = 0.22) and information transmission efficiency (r = 0.55, r = 0.28). S-F coupling was related to basic academic ability (r = 0.39) and disinhibition (r = 0.49).
Data conclusion: PSP may show abnormal S-F coupling and intramodular and intermodular connectome in the structural and functional networks.
期刊介绍：
The Journal of Magnetic Resonance Imaging (JMRI) is an international journal devoted to the timely publication of basic and clinical research, educational and review articles, and other information related to the diagnostic applications of magnetic resonance.
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