使用海藻酸盐-卡拉胶组合制成的槲皮素豆球的物理特性:聚合物浓度的影响。

IF 1.4 Q3 Pharmacology, Toxicology and Pharmaceutics
Dewi Melani Hariyadi, Lubby Razan Fawwaz, Abdul Fattah, Tutiek Purwanti, Tristiana Erawati
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引用次数: 0

摘要

根据世界卫生组织《2020 年全球报告》,印度尼西亚是世界上肺结核(TB)病例数第二高的国家,在东南亚则是第一高的国家。槲皮素已被尝试作为一种替代疗法,并被证明有效。本研究旨在利用组合聚合物优化槲皮素肺泡球,并研究其作为吸入给药系统的特性。组合聚合物具有安全、粘附性强、体积小等优点。肺泡球的配方分别为 F1、F2 和 F3(聚合物比例为 1:1、1:2 和 1:3)。对槲皮素 0.2%、海藻酸卡拉胶(总浓度为 1.8%)和 0.5 M CaCl2 的粒径、形态、含水量(MC)、产率、载药量和包埋效率(EE)进行了表征。产率范围为 83.89% 至 86.30% ± 4.59%。MC 范围为 4.23 至 5.12% ± 0.05%。粒度是体外释放和体内研究的指标。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Physical characteristics of quercetin pulmospheres using combination of alginate-carrageenan: Effect of polymer concentration.

Indonesia is the second country with the highest number of tuberculosis (TB) cases in the world and the first in Southeast Asia, according to WHO Global Report 2020. Quercetin has been tried as an alternative therapy and was found effective. This study aims to optimize quercetin pulmospheres using combination polymers and study its characteristics as an inhalation delivery system. Combination polymers provide the advantages of safe, mucoadhesive, and compact pulmospheres. Pulmospheres were made as formula F1, F2, and F3 (polymer ratios of 1:1, 1:2, and 1:3), respectively. Pulmospheres were made with quercetin 0.2%, alginate-carrageenan (total concentration of 1.8%), and CaCl2 0.5 M. Characterization of particle size, morphology, moisture content (MC), yield, drug loading, and entrapment efficiency (EE) were conducted. The yield range was from 83.89 to 86.30% ± 4.59%. MC range was from 4.23 to 5.12% ± 0.05%. Particle size was <3 µm (between 2.19 and 2.76 ± 0.149 µm), spherical shape and smooth surface. EE range was 60.69% ± 4.45% to 77.86% ± 1.74% and the drug loading range was 1.66-2.09% ± 0.15%. F2 formula with a polymer ratio of 1:2 was the best quercetin pulmospheres. Potential pulmospheres will then be recommended for in vitro release and in vivo study.

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来源期刊
CiteScore
2.00
自引率
7.10%
发文量
44
审稿时长
20 weeks
期刊介绍: Journal of Advanced Pharmaceutical Technology & Research (JAPTR) is an Official Publication of Society of Pharmaceutical Education & Research™. It is an international journal published Quarterly. Journal of Advanced Pharmaceutical Technology & Research (JAPTR) is available in online and print version. It is a peer reviewed journal aiming to communicate high quality original research work, reviews, short communications, case report, Ethics Forum, Education Forum and Letter to editor that contribute significantly to further the scientific knowledge related to the field of Pharmacy i.e. Pharmaceutics, Pharmacology, Pharmacognosy, Pharmaceutical Chemistry. Articles with timely interest and newer research concepts will be given more preference.
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