{"title":"Oroxylum indicum 软膏对人畜共通病菌的抑制作用以及对狗伤口的影响。","authors":"Patchima Sithisarn, Piyanuch Rojsanga, Pakatip Ruenraroengsak, Pongtip Sithisarn","doi":"10.4103/JAPTR.JAPTR_97_24","DOIUrl":null,"url":null,"abstract":"<p><p>A topical antimicrobial ointment was developed from the fruit extract of <i>Oroxylum</i> <i>indicum</i> and was evaluated for its antibacterial and wound-healing effects and acute toxicity in animal models. <i>O.</i> <i>indicum</i> fruit and seed extracts exhibited antibacterial activities against clinically isolated bacteria and showed <i>in vitro</i> antioxidant activities. To develop a topical antimicrobial ointment from the fruit extract of <i>O.</i> <i>indicum</i> and evaluate for its antibacterial and wound-healing effects. <i>O.</i> <i>indicum</i> fruit extract ointment was prepared and qualitatively controlled. Acute toxicity of the extract was evaluated in the animal model. Antibacterial effects and healing effects of the ointment to the dog wound were investigated. The results are expressed as mean ± standard deviation. The ointment exhibited <i>in</i> <i>vitro</i> antibacterial effects. A single daily application of the ointment to a dog's wound exhibited a wound-healing effect with complete epithelialization within 7 days while the wound was completely healed with the removal of the scabs, the size was decreased to 14% of the original size within 12 days. The ointment was found no acute toxicity in the animal model. <i>O.</i> <i>indicum</i> ointment promoted <i>in vitro</i> antibacterial activity and wound-healing effect in dogs with no acute toxicity.</p>","PeriodicalId":14877,"journal":{"name":"Journal of Advanced Pharmaceutical Technology & Research","volume":null,"pages":null},"PeriodicalIF":1.4000,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11404433/pdf/","citationCount":"0","resultStr":"{\"title\":\"Inhibitory effects against zoonotic bacteria by <i>Oroxylum indicum</i> ointment and effects to dog wound.\",\"authors\":\"Patchima Sithisarn, Piyanuch Rojsanga, Pakatip Ruenraroengsak, Pongtip Sithisarn\",\"doi\":\"10.4103/JAPTR.JAPTR_97_24\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>A topical antimicrobial ointment was developed from the fruit extract of <i>Oroxylum</i> <i>indicum</i> and was evaluated for its antibacterial and wound-healing effects and acute toxicity in animal models. <i>O.</i> <i>indicum</i> fruit and seed extracts exhibited antibacterial activities against clinically isolated bacteria and showed <i>in vitro</i> antioxidant activities. To develop a topical antimicrobial ointment from the fruit extract of <i>O.</i> <i>indicum</i> and evaluate for its antibacterial and wound-healing effects. <i>O.</i> <i>indicum</i> fruit extract ointment was prepared and qualitatively controlled. Acute toxicity of the extract was evaluated in the animal model. Antibacterial effects and healing effects of the ointment to the dog wound were investigated. The results are expressed as mean ± standard deviation. The ointment exhibited <i>in</i> <i>vitro</i> antibacterial effects. A single daily application of the ointment to a dog's wound exhibited a wound-healing effect with complete epithelialization within 7 days while the wound was completely healed with the removal of the scabs, the size was decreased to 14% of the original size within 12 days. The ointment was found no acute toxicity in the animal model. <i>O.</i> <i>indicum</i> ointment promoted <i>in vitro</i> antibacterial activity and wound-healing effect in dogs with no acute toxicity.</p>\",\"PeriodicalId\":14877,\"journal\":{\"name\":\"Journal of Advanced Pharmaceutical Technology & Research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.4000,\"publicationDate\":\"2024-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11404433/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Advanced Pharmaceutical Technology & Research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4103/JAPTR.JAPTR_97_24\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/7/22 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"Pharmacology, Toxicology and Pharmaceutics\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Advanced Pharmaceutical Technology & Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/JAPTR.JAPTR_97_24","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/7/22 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"Pharmacology, Toxicology and Pharmaceutics","Score":null,"Total":0}
引用次数: 0
摘要
研究人员从 Oroxylum indicum 的果实萃取物中开发出一种局部抗菌软膏,并在动物模型中对其抗菌、伤口愈合效果和急性毒性进行了评估。O. indicum 果实和种子提取物对临床分离的细菌具有抗菌活性,并具有体外抗氧化活性。从 O. indicum 果实提取物中开发一种局部抗菌软膏,并评估其抗菌和伤口愈合效果。制备了 O. indicum 果实提取物软膏,并对其进行了质量控制。在动物模型中评估了提取物的急性毒性。研究了药膏对狗伤口的抗菌效果和愈合效果。结果以平均值 ± 标准偏差表示。软膏具有体外抗菌效果。在狗的伤口上每天涂抹一次药膏,可在 7 天内使伤口完全上皮化,伤口完全愈合,痂皮脱落,12 天内伤口面积减小到原来的 14%。该药膏在动物模型中没有发现急性毒性。O. indicum 软膏促进了狗的体外抗菌活性和伤口愈合效果,且无急性毒性。
Inhibitory effects against zoonotic bacteria by Oroxylum indicum ointment and effects to dog wound.
A topical antimicrobial ointment was developed from the fruit extract of Oroxylumindicum and was evaluated for its antibacterial and wound-healing effects and acute toxicity in animal models. O.indicum fruit and seed extracts exhibited antibacterial activities against clinically isolated bacteria and showed in vitro antioxidant activities. To develop a topical antimicrobial ointment from the fruit extract of O.indicum and evaluate for its antibacterial and wound-healing effects. O.indicum fruit extract ointment was prepared and qualitatively controlled. Acute toxicity of the extract was evaluated in the animal model. Antibacterial effects and healing effects of the ointment to the dog wound were investigated. The results are expressed as mean ± standard deviation. The ointment exhibited invitro antibacterial effects. A single daily application of the ointment to a dog's wound exhibited a wound-healing effect with complete epithelialization within 7 days while the wound was completely healed with the removal of the scabs, the size was decreased to 14% of the original size within 12 days. The ointment was found no acute toxicity in the animal model. O.indicum ointment promoted in vitro antibacterial activity and wound-healing effect in dogs with no acute toxicity.
期刊介绍:
Journal of Advanced Pharmaceutical Technology & Research (JAPTR) is an Official Publication of Society of Pharmaceutical Education & Research™. It is an international journal published Quarterly. Journal of Advanced Pharmaceutical Technology & Research (JAPTR) is available in online and print version. It is a peer reviewed journal aiming to communicate high quality original research work, reviews, short communications, case report, Ethics Forum, Education Forum and Letter to editor that contribute significantly to further the scientific knowledge related to the field of Pharmacy i.e. Pharmaceutics, Pharmacology, Pharmacognosy, Pharmaceutical Chemistry. Articles with timely interest and newer research concepts will be given more preference.