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引用次数: 0
摘要
PD-1 在急性髓性白血病（AML）的发病过程中具有值得注意的功能。PD-1 在效应 T 细胞上的表达受蛋白质水平的调控，这取决于细胞间的相互作用。本研究旨在评估伊拉克阿拉伯裔急性髓性白血病患者的 PD-1 浓度水平和多态性遗传变异（rs36084323 G/A）。研究采用了 Sanger DNA 测序技术，并通过酶联免疫吸附试验和 PD-1 基因多态性 SNP rs36084323 G/A 进行了评估。rs36084323的频率在急性髓细胞性白血病和对照组之间存在显著差异，GA基因型患者发生急性髓细胞性白血病的风险较低（几率比；95%置信区间：0.53；0.32-0.87）。与对照组相比，急性髓细胞性白血病患者的 PD-1 升高（213.1 pg/mL vs. 178.8 pg/mL）。急性髓细胞性白血病患者的 PD-1 上调，这表明 PD-1 可能是急性髓细胞性白血病的生物标志物。PD-1 rs36084323 G/A 可能对急性髓细胞性白血病的风险有影响。
Genetic polymorphism and immunological evaluation of PD-1 in Iraqi patients with acute myeloid leukemia.
PD-1 has a noteworthy function in developing acute myeloid leukemia (AML). The expression of PD-1 on effector T cells is regulated at the protein level depending on the interactions between cells. The objective of the study was to evaluate the PD-1 concentration levels and the polymorphism genetic variants (rs36084323 G/A) in Iraqi Arab patients with AML. Sanger's DNA sequencing was used, and the assessments were done by enzyme-linked immunosorbent assay and PD-1 gene polymorphism SNP rs36084323 G/A. The frequency of rs36084323 was significantly different between AML and control, with a lower risk for AML seen in patients with GA genotype (odds ratio; 95% confidence interval: 0.53; 0.32-0.87). PD-1 elevated AML compared to control (213.1 pg/mL vs. 178.8 pg/mL). in AML patients, there is upregulation in PD-1, which indicates that PD-1 is a possible biomarker for AML. PD-1 rs36084323 G/A may have a role in AML risk.
期刊介绍：
Journal of Advanced Pharmaceutical Technology & Research (JAPTR) is an Official Publication of Society of Pharmaceutical Education & Research™. It is an international journal published Quarterly. Journal of Advanced Pharmaceutical Technology & Research (JAPTR) is available in online and print version. It is a peer reviewed journal aiming to communicate high quality original research work, reviews, short communications, case report, Ethics Forum, Education Forum and Letter to editor that contribute significantly to further the scientific knowledge related to the field of Pharmacy i.e. Pharmaceutics, Pharmacology, Pharmacognosy, Pharmaceutical Chemistry. Articles with timely interest and newer research concepts will be given more preference.
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