橙皮甙对预防氯化铝引起的大鼠睾丸功能障碍的影响

IF 1.4 Q3 Pharmacology, Toxicology and Pharmaceutics
Subramani Parasuraman, Loh Yee Huey, Yap Shen Jee
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引用次数: 0

摘要

橙皮甙是一种柑橘类生物黄酮,具有多种药理作用。橙皮甙对睾丸功能障碍的影响尚未得到充分研究。因此,本研究旨在探讨橙皮甙对氯化铝(AlCl3)诱导的大鼠睾丸功能障碍的影响。大鼠口服维生素 C(每公斤 200 毫克)和橙皮甙(每公斤 50、100 和 200 毫克)21 天。研究结束时,采集所有动物的血液样本,以检测生化指标和血液学指标。然后,进行双侧睾丸切除术,取出动物的睾丸,收集精子并在显微镜下进行检查。最后,还收集了肝脏、肾脏和睾丸等器官,用于组织病理学分析。部分肝脏样本用于测定抗氧化酶,如还原型谷胱甘肽(GSH)和过氧化氢酶(CAT)的水平。服用氯化铝的大鼠显示生化和血液学参数水平升高,精子数量、精子活力和氧化应激参数水平降低,而服用维生素 C/橙皮素(200 和 400 毫克/千克)的大鼠能够通过减轻氯化铝引起的生化和血液学参数、精子活力、精子数量和氧化应激的变化,改善氯化铝引起的睾丸功能障碍。维生素 C 和橙皮甙对 AlCl3 引起的睾丸功能障碍都有显著的改善作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effect of hesperidin in the prevention of aluminum chloride-induced testicular dysfunction in rats.

Hesperidin is a citrus bioflavonoid and has numerous pharmacological actions. Hesperidin's effect on testicular dysfunction has not been well researched. Hence, the present study is aims to investigate the effect of hesperidin on aluminium chloride (AlCl3)-induced testicular dysfunction in rats. Both vitamin C (200 mg/kg) and hesperidin (50, 100, and 200 mg/kg) were administered orally for 21 days. At the end of the study, the blood samples were obtained from all animals for investigation of biochemical and hematological parameters. Then, bilateral orchiectomy was carried out to remove testicles from the animals, and sperm was collected and examined under a microscope. Finally, organs such as the liver, kidney, and testicles were also collected and utilized for histopathological analysis. Part of the liver sample was used for determination of antioxidant enzymes such as reduced glutathione (GSH) and catalase (CAT) levels. The rats administered with AlCl3 showed elevated levels of biochemical and hematological parameters and a reduction in levels of sperm count, sperm motility, and oxidative stress parameters, whereas the rats administered with vitamin C/hesperidin (200 and 400 mg/kg) were able to ameliorate AlCl3-induced testicular dysfunction by attenuating AlCl3-induced changes in biochemical and hematological parameters, sperm motility, sperm count, and oxidative stress. Both vitamin C and hesperidin had significant ameliorative effects against AlCl3-induced testicular dysfunction.

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来源期刊
CiteScore
2.00
自引率
7.10%
发文量
44
审稿时长
20 weeks
期刊介绍: Journal of Advanced Pharmaceutical Technology & Research (JAPTR) is an Official Publication of Society of Pharmaceutical Education & Research™. It is an international journal published Quarterly. Journal of Advanced Pharmaceutical Technology & Research (JAPTR) is available in online and print version. It is a peer reviewed journal aiming to communicate high quality original research work, reviews, short communications, case report, Ethics Forum, Education Forum and Letter to editor that contribute significantly to further the scientific knowledge related to the field of Pharmacy i.e. Pharmaceutics, Pharmacology, Pharmacognosy, Pharmaceutical Chemistry. Articles with timely interest and newer research concepts will be given more preference.
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