SARS-CoV-2 Omicron XBB.1变体在特定人群中的爆发：结合体液反应纵向评估的流行病学调查。

IF 4.8 2区医学 Q1 INFECTIOUS DISEASES

International Journal of Infectious Diseases Pub Date : 2024-09-11 DOI:10.1016/j.ijid.2024.107240

Ili Margalit , Yael Weiss-Ottolenghi , Einat Panet , Victoria Indenbaum , Neta S. Zuckerman , Gili Joseph , Yovel Peretz , Noam Barda , Yaniv Lustig , Gili Regev-Yochay

{"title":"SARS-CoV-2 Omicron XBB.1变体在特定人群中的爆发：结合体液反应纵向评估的流行病学调查。","authors":"Ili Margalit , Yael Weiss-Ottolenghi , Einat Panet , Victoria Indenbaum , Neta S. Zuckerman , Gili Joseph , Yovel Peretz , Noam Barda , Yaniv Lustig , Gili Regev-Yochay","doi":"10.1016/j.ijid.2024.107240","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>We describe an epidemiological investigation of a SARS-CoV-2-XBB.1 outbreak among healthcare workers (HCWs) returning from a 5-days educational tour abroad.</div></div><div><h3>Methods</h3><div>We prospectively followed participants for symptoms and sampled blood for neutralization assays of four SARS-CoV-2 variants (wild type, XBB, EG.5.1, and BA.2.86) at 1, 3, and 6 months after their return. When available, samples from the 3 months preceding the outbreak were also tested. We compared geometric mean titers (GMT) of neutralizing antibodies of infected versus uninfected HCWs and febrile versus afebrile infected HCWs.</div></div><div><h3>Results</h3><div>Nineteen (10%) of 181 HCWs were infected, all had mild COVID-19, 90% (17/19) had symptoms, and 16% (3/19) reported fever. Infected individuals tended to have lower pre-exposure XBB-neutralizing antibody titers (GMT of 32 versus 107 ID50, <em>P</em> = 0.248). Neutralization against XBB and newer subvariants peaked at 3 months and was higher among infected individuals (GMT 702 versus 156 [<em>P</em> < 0.001], 558 versus 163 [<em>P</em> = 0.001], and 558 vs. 182 [<em>P</em> = 0.002], ID50 for XBB, EG.5.1., and BA.2.86, respectively). By six months, these differences were no longer observed. Fever was positively associated with XBB neutralization (GMT 3474 versus 485, ID50 <em>P</em> = 0.005).</div></div><div><h3>Conclusions</h3><div>Recently infected individuals are protected from reinfection with newer subvariants. However, protection is likely short lived.</div></div>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":"148 ","pages":"Article 107240"},"PeriodicalIF":4.8000,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"SARS-CoV-2 Omicron XBB.1 variant outbreak in a defined cohort: an epidemiological investigation incorporating longitudinal assessment of humoral response\",\"authors\":\"Ili Margalit , Yael Weiss-Ottolenghi , Einat Panet , Victoria Indenbaum , Neta S. Zuckerman , Gili Joseph , Yovel Peretz , Noam Barda , Yaniv Lustig , Gili Regev-Yochay\",\"doi\":\"10.1016/j.ijid.2024.107240\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><div>We describe an epidemiological investigation of a SARS-CoV-2-XBB.1 outbreak among healthcare workers (HCWs) returning from a 5-days educational tour abroad.</div></div><div><h3>Methods</h3><div>We prospectively followed participants for symptoms and sampled blood for neutralization assays of four SARS-CoV-2 variants (wild type, XBB, EG.5.1, and BA.2.86) at 1, 3, and 6 months after their return. When available, samples from the 3 months preceding the outbreak were also tested. We compared geometric mean titers (GMT) of neutralizing antibodies of infected versus uninfected HCWs and febrile versus afebrile infected HCWs.</div></div><div><h3>Results</h3><div>Nineteen (10%) of 181 HCWs were infected, all had mild COVID-19, 90% (17/19) had symptoms, and 16% (3/19) reported fever. Infected individuals tended to have lower pre-exposure XBB-neutralizing antibody titers (GMT of 32 versus 107 ID50, <em>P</em> = 0.248). Neutralization against XBB and newer subvariants peaked at 3 months and was higher among infected individuals (GMT 702 versus 156 [<em>P</em> < 0.001], 558 versus 163 [<em>P</em> = 0.001], and 558 vs. 182 [<em>P</em> = 0.002], ID50 for XBB, EG.5.1., and BA.2.86, respectively). By six months, these differences were no longer observed. Fever was positively associated with XBB neutralization (GMT 3474 versus 485, ID50 <em>P</em> = 0.005).</div></div><div><h3>Conclusions</h3><div>Recently infected individuals are protected from reinfection with newer subvariants. However, protection is likely short lived.</div></div>\",\"PeriodicalId\":14006,\"journal\":{\"name\":\"International Journal of Infectious Diseases\",\"volume\":\"148 \",\"pages\":\"Article 107240\"},\"PeriodicalIF\":4.8000,\"publicationDate\":\"2024-09-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Infectious Diseases\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1201971224003114\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"INFECTIOUS DISEASES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Infectious Diseases","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1201971224003114","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}

引用次数: 0

摘要

背景：我们描述了一项流行病学调查，调查对象是从国外参加为期 5 天的教育考察活动归来的医护人员（HCWs）中爆发的由 SARS-CoV-2-XBB.1 引起的 COVID-19 事件：我们对参与者的症状进行了前瞻性追踪，并在他们回国后的 1、3 和 6 个月抽取血液样本进行四种 SARS-CoV-2 变体（野生型、XBB、EG.5.1 和 BA.2.86）的中和检测。如果有疫情爆发前 3 个月的样本，也对其进行检测。我们比较了感染与未感染高危女工以及发热与非发热感染高危女工的中和抗体滴度的几何平均滴度（GMT）：181名医务人员中有19人（10%）受到感染，所有感染者都有轻度COVID-19，90%（17/19）的感染者有症状，16%（3/19）的感染者报告发烧。感染者暴露前的 XBB 中和抗体滴度往往较低（GMT 为 32，ID50 为 107，P=0.248）。针对 XBB 和较新亚变体的中和抗体在 3 个月时达到峰值，感染者的抗体滴度较高（GMT 为 702 vs 156 [p结论：新近感染的个体受到保护，不会再次感染较新的亚变体。然而，这种保护可能是短暂的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

SARS-CoV-2 Omicron XBB.1 variant outbreak in a defined cohort: an epidemiological investigation incorporating longitudinal assessment of humoral response

Background

We describe an epidemiological investigation of a SARS-CoV-2-XBB.1 outbreak among healthcare workers (HCWs) returning from a 5-days educational tour abroad.

Methods

We prospectively followed participants for symptoms and sampled blood for neutralization assays of four SARS-CoV-2 variants (wild type, XBB, EG.5.1, and BA.2.86) at 1, 3, and 6 months after their return. When available, samples from the 3 months preceding the outbreak were also tested. We compared geometric mean titers (GMT) of neutralizing antibodies of infected versus uninfected HCWs and febrile versus afebrile infected HCWs.

Results

Nineteen (10%) of 181 HCWs were infected, all had mild COVID-19, 90% (17/19) had symptoms, and 16% (3/19) reported fever. Infected individuals tended to have lower pre-exposure XBB-neutralizing antibody titers (GMT of 32 versus 107 ID50, P = 0.248). Neutralization against XBB and newer subvariants peaked at 3 months and was higher among infected individuals (GMT 702 versus 156 [P < 0.001], 558 versus 163 [P = 0.001], and 558 vs. 182 [P = 0.002], ID50 for XBB, EG.5.1., and BA.2.86, respectively). By six months, these differences were no longer observed. Fever was positively associated with XBB neutralization (GMT 3474 versus 485, ID50 P = 0.005).

Conclusions

Recently infected individuals are protected from reinfection with newer subvariants. However, protection is likely short lived.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

International Journal of Infectious Diseases 医学-传染病学

CiteScore

18.90

自引率

2.40%

发文量

1020

审稿时长

30 days

期刊介绍： International Journal of Infectious Diseases (IJID) Publisher: International Society for Infectious Diseases Publication Frequency: Monthly Type: Peer-reviewed, Open Access Scope: Publishes original clinical and laboratory-based research. Reports clinical trials, reviews, and some case reports. Focuses on epidemiology, clinical diagnosis, treatment, and control of infectious diseases. Emphasizes diseases common in under-resourced countries.