Nina Schöbi, Andrea Duppenthaler, Matthias Horn, Andreas Bartenstein, Kristina Keitel, Matthias V Kopp, Philipp K A Agyeman, Christoph Aebi
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引用次数: 0
摘要
2022年秋季，欧洲范围内爆发了侵袭性儿科A群链球菌感染（iGAS）。在此，我们报告了瑞士一家三级医疗中心在 2023-2024 年疫情爆发第二年期间儿童和青少年 A 组链球菌感染住院病例的变化情况。通过对所有 16 岁以下的 GAS 住院病例（包括 iGAS 患者）进行前瞻性监测，我们比较了三个时间段（2013-2020 年；2022-2023 年；2023-2024 年）的病例频率和临床特征。iGAS 病例的变化情况类似（2013-2020 年，4 例（3-8 例）；2022-2023 年，32 例；2023-2024 年，21 例）。从2022-2023年到2023-2024年，病例数的下降包括所有类型的GAS器官受累，但头部化脓性感染除外，这部分病例数基本保持不变（48例与45例）。胸腔积液从13例减少到7例，这可能是因为与2022-2023年相比，2023-2024年的GAS和流感曲线重合度较低。这些数据表明，在2023-2024年的第二个冬季，肺炎疫情持续时间延长。
Ongoing Excess Hospitalizations for Severe Pediatric Group A Streptococcal Disease in 2023-2024-A Single-Center Report.
A Europe-wide outbreak of invasive pediatric group A streptococcal infections (iGAS) began in fall 2022. Here, we report the evolution of GAS hospitalizations in children and adolescents during the second outbreak year in 2023-2024 at a tertiary center in Switzerland. Using prospective monitoring of all in-patient GAS cases below 16 years of age, including those with iGAS, we compared case frequencies and clinical characteristics in three time periods (2013-2020; 2022-2023; 2023-2024). Annual GAS hospitalizations increased from a median of 25 cases (range 11-28) in 2013-2020 to 89 and 63 cases, respectively, in 2022-2023 and 2023-2024. iGAS cases evolved similarly (2013-2020, 4 cases (3-8); 2022-2023, 32 cases; 2023-2024, 21 cases). The decline in cases from 2022-2023 to 2023-2024 included all types of GAS organ involvement, except suppurative infections in the head area, which remained largely unchanged (48 vs. 45 cases). Pleural empyema declined from 13 to 7 cases, possibly explained by a poor overlap of the GAS and influenza curves, respectively, in 2023-2024 compared to 2022-2023. These data document the prolongation of the GAS outbreak into its second winter season in 2023-2024.
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