{"title":"龈沟液中瘦素浓度与正畸牙齿移动速度的相关性--一项前瞻性研究","authors":"Adel Alharbi, Rinkee Mohanty, Geetika Tomer, Atul Anand Bajoria, Azhar Mohammed, Prashant Babaji","doi":"10.4103/ijdr.ijdr_714_22","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>The evaluation of genetic markers in the gingival crevicular fluid (GCF) and their connection to tooth movement can be helpful.</p><p><strong>Aim: </strong>The objective of this research is to assess the relationship involving leptin levels and orthodontic tooth movement (OTM).</p><p><strong>Study setting and design: </strong>Thirty individuals reporting to the Department of Orthodontics participated in an observational prospective study.</p><p><strong>Material and method: </strong>Thirty orthodontic patients (15 male and 15 female) were included in the current study. The association of leptin concentration (GCF) was measured before and after orthodontic force was applied to move the mesially impacted canine distally (tooth movement distance on dental cast).</p><p><strong>Statistical analysis: </strong>With the help of SPSS software version 21, the data were statistically examined using the \" t \" test, one-way ANOVA, and Bonferroni correction in Chicago. The average degree of tooth movement was calculated using Pearson's correlation coefficient, and it was connected to the average leptin levels.</p><p><strong>Results: </strong>Average leptin levels in GCF elevated from baseline (T0, 285.315 picograms/micro litre) to 1 h after force application (T1, 384.683 pg/μL), then raised to a maximum at after 24 h (T2, 927.64 pg/μL), and decreased to the least amount after 15 days (T3, 29.26 pg/μL) and another time increase after two months (242.31 pg/μL). The degree of OTM was significantly correlated with the levels of leptin.</p><p><strong>Conclusion: </strong>While OTM was occurring, a biphasic fluctuation in the leptin level was noted. The amount of tooth movement was significantly correlated with the GCF leptin level.</p>","PeriodicalId":13311,"journal":{"name":"Indian Journal of Dental Research","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Correlation of Leptin Concentration in Gingival Crevicular Fluid on the Rate of Orthodontic Tooth Movement - A Prospective Study.\",\"authors\":\"Adel Alharbi, Rinkee Mohanty, Geetika Tomer, Atul Anand Bajoria, Azhar Mohammed, Prashant Babaji\",\"doi\":\"10.4103/ijdr.ijdr_714_22\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>The evaluation of genetic markers in the gingival crevicular fluid (GCF) and their connection to tooth movement can be helpful.</p><p><strong>Aim: </strong>The objective of this research is to assess the relationship involving leptin levels and orthodontic tooth movement (OTM).</p><p><strong>Study setting and design: </strong>Thirty individuals reporting to the Department of Orthodontics participated in an observational prospective study.</p><p><strong>Material and method: </strong>Thirty orthodontic patients (15 male and 15 female) were included in the current study. The association of leptin concentration (GCF) was measured before and after orthodontic force was applied to move the mesially impacted canine distally (tooth movement distance on dental cast).</p><p><strong>Statistical analysis: </strong>With the help of SPSS software version 21, the data were statistically examined using the \\\" t \\\" test, one-way ANOVA, and Bonferroni correction in Chicago. The average degree of tooth movement was calculated using Pearson's correlation coefficient, and it was connected to the average leptin levels.</p><p><strong>Results: </strong>Average leptin levels in GCF elevated from baseline (T0, 285.315 picograms/micro litre) to 1 h after force application (T1, 384.683 pg/μL), then raised to a maximum at after 24 h (T2, 927.64 pg/μL), and decreased to the least amount after 15 days (T3, 29.26 pg/μL) and another time increase after two months (242.31 pg/μL). The degree of OTM was significantly correlated with the levels of leptin.</p><p><strong>Conclusion: </strong>While OTM was occurring, a biphasic fluctuation in the leptin level was noted. The amount of tooth movement was significantly correlated with the GCF leptin level.</p>\",\"PeriodicalId\":13311,\"journal\":{\"name\":\"Indian Journal of Dental Research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Indian Journal of Dental Research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4103/ijdr.ijdr_714_22\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/9/14 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"Dentistry\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Indian Journal of Dental Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/ijdr.ijdr_714_22","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/9/14 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"Dentistry","Score":null,"Total":0}
Correlation of Leptin Concentration in Gingival Crevicular Fluid on the Rate of Orthodontic Tooth Movement - A Prospective Study.
Background: The evaluation of genetic markers in the gingival crevicular fluid (GCF) and their connection to tooth movement can be helpful.
Aim: The objective of this research is to assess the relationship involving leptin levels and orthodontic tooth movement (OTM).
Study setting and design: Thirty individuals reporting to the Department of Orthodontics participated in an observational prospective study.
Material and method: Thirty orthodontic patients (15 male and 15 female) were included in the current study. The association of leptin concentration (GCF) was measured before and after orthodontic force was applied to move the mesially impacted canine distally (tooth movement distance on dental cast).
Statistical analysis: With the help of SPSS software version 21, the data were statistically examined using the " t " test, one-way ANOVA, and Bonferroni correction in Chicago. The average degree of tooth movement was calculated using Pearson's correlation coefficient, and it was connected to the average leptin levels.
Results: Average leptin levels in GCF elevated from baseline (T0, 285.315 picograms/micro litre) to 1 h after force application (T1, 384.683 pg/μL), then raised to a maximum at after 24 h (T2, 927.64 pg/μL), and decreased to the least amount after 15 days (T3, 29.26 pg/μL) and another time increase after two months (242.31 pg/μL). The degree of OTM was significantly correlated with the levels of leptin.
Conclusion: While OTM was occurring, a biphasic fluctuation in the leptin level was noted. The amount of tooth movement was significantly correlated with the GCF leptin level.
期刊介绍:
Indian Journal of Dental Research (IJDR) is the official publication of the Indian Society for Dental Research (ISDR), India section of the International Association for Dental Research (IADR), published quarterly. IJDR publishes scientific papers on well designed and controlled original research involving orodental sciences. Papers may also include reports on unusual and interesting case presentations and invited review papers on significant topics.