肥胖症患者肠道微生物群失调导致卵母细胞质量受损。

IF 4.3 3区 材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC
Liying Shan , Haitao Fan , Jing Guo , Heyang Zhou , Fengguo Li , Zhimin Jiang , Duo Wu , Xinlei Feng , Ren Mo , Yongbin Liu , Teng Zhang , Yang Zhou
{"title":"肥胖症患者肠道微生物群失调导致卵母细胞质量受损。","authors":"Liying Shan ,&nbsp;Haitao Fan ,&nbsp;Jing Guo ,&nbsp;Heyang Zhou ,&nbsp;Fengguo Li ,&nbsp;Zhimin Jiang ,&nbsp;Duo Wu ,&nbsp;Xinlei Feng ,&nbsp;Ren Mo ,&nbsp;Yongbin Liu ,&nbsp;Teng Zhang ,&nbsp;Yang Zhou","doi":"10.1016/j.ygeno.2024.110941","DOIUrl":null,"url":null,"abstract":"<div><div>Obesity poses risks to oocyte maturation and embryonic development in mice and humans, linked to gut microbiota dysbiosis and altered host metabolomes. However, it is unclear whether symbiotic gut microbes have a pivotal role in oocyte quality. In mouse models of fecal microbiota transplantation, we demonstrated aberrant meiotic apparatus and impaired maternal mRNA in oocytes, which is coincident with the poor developmental competence of embryos. Using metabolomics profiling, we discovered that the cytosine and cytidine metabolism was disturbed, which could account for the fertility defects observed in the high-fat diet (HFD) recipient mice. Additionally, cytosine and cytidine are closely related with gut microbiota dysbiosis, which is accompanied by a notable reduction of abundance of <em>Christensenellaceae R-7 group</em> in the HFD mice. In summary, our findings provided evidence that modifying the gut microbiota may be of value in the treatment of infertile female individuals with obesity.</div></div>","PeriodicalId":3,"journal":{"name":"ACS Applied Electronic Materials","volume":null,"pages":null},"PeriodicalIF":4.3000,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0888754324001629/pdfft?md5=8f2cb2a04be423f8074b7ebdca3ae05b&pid=1-s2.0-S0888754324001629-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Impairment of oocyte quality caused by gut microbiota dysbiosis in obesity\",\"authors\":\"Liying Shan ,&nbsp;Haitao Fan ,&nbsp;Jing Guo ,&nbsp;Heyang Zhou ,&nbsp;Fengguo Li ,&nbsp;Zhimin Jiang ,&nbsp;Duo Wu ,&nbsp;Xinlei Feng ,&nbsp;Ren Mo ,&nbsp;Yongbin Liu ,&nbsp;Teng Zhang ,&nbsp;Yang Zhou\",\"doi\":\"10.1016/j.ygeno.2024.110941\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Obesity poses risks to oocyte maturation and embryonic development in mice and humans, linked to gut microbiota dysbiosis and altered host metabolomes. However, it is unclear whether symbiotic gut microbes have a pivotal role in oocyte quality. In mouse models of fecal microbiota transplantation, we demonstrated aberrant meiotic apparatus and impaired maternal mRNA in oocytes, which is coincident with the poor developmental competence of embryos. Using metabolomics profiling, we discovered that the cytosine and cytidine metabolism was disturbed, which could account for the fertility defects observed in the high-fat diet (HFD) recipient mice. Additionally, cytosine and cytidine are closely related with gut microbiota dysbiosis, which is accompanied by a notable reduction of abundance of <em>Christensenellaceae R-7 group</em> in the HFD mice. In summary, our findings provided evidence that modifying the gut microbiota may be of value in the treatment of infertile female individuals with obesity.</div></div>\",\"PeriodicalId\":3,\"journal\":{\"name\":\"ACS Applied Electronic Materials\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.3000,\"publicationDate\":\"2024-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S0888754324001629/pdfft?md5=8f2cb2a04be423f8074b7ebdca3ae05b&pid=1-s2.0-S0888754324001629-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ACS Applied Electronic Materials\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0888754324001629\",\"RegionNum\":3,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ENGINEERING, ELECTRICAL & ELECTRONIC\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Electronic Materials","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0888754324001629","RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, ELECTRICAL & ELECTRONIC","Score":null,"Total":0}
引用次数: 0

摘要

肥胖对小鼠和人类的卵母细胞成熟和胚胎发育构成风险,这与肠道微生物群失调和宿主代谢组改变有关。然而,目前还不清楚共生肠道微生物是否在卵母细胞质量中起着关键作用。在粪便微生物群移植的小鼠模型中,我们发现卵母细胞中的减数分裂装置异常和母体mRNA受损,这与胚胎发育能力低下不谋而合。通过代谢组学分析,我们发现胞嘧啶和胞苷酸代谢紊乱,这可能是高脂饮食(HFD)受体小鼠生育缺陷的原因。此外,胞嘧啶和胞苷与肠道微生物群失调密切相关,高脂饮食小鼠肠道微生物群失调伴随着克里斯滕森菌科 R-7 群丰度的显著降低。总之,我们的研究结果提供了证据,表明改变肠道微生物群可能对患有肥胖症的不育雌性个体有治疗价值。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Impairment of oocyte quality caused by gut microbiota dysbiosis in obesity
Obesity poses risks to oocyte maturation and embryonic development in mice and humans, linked to gut microbiota dysbiosis and altered host metabolomes. However, it is unclear whether symbiotic gut microbes have a pivotal role in oocyte quality. In mouse models of fecal microbiota transplantation, we demonstrated aberrant meiotic apparatus and impaired maternal mRNA in oocytes, which is coincident with the poor developmental competence of embryos. Using metabolomics profiling, we discovered that the cytosine and cytidine metabolism was disturbed, which could account for the fertility defects observed in the high-fat diet (HFD) recipient mice. Additionally, cytosine and cytidine are closely related with gut microbiota dysbiosis, which is accompanied by a notable reduction of abundance of Christensenellaceae R-7 group in the HFD mice. In summary, our findings provided evidence that modifying the gut microbiota may be of value in the treatment of infertile female individuals with obesity.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
7.20
自引率
4.30%
发文量
567
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信