自发性高血压大鼠肾脏结构变化和凋亡素受体表达:对高血压诱发肾损伤的影响

IF 1.2 4区 医学 Q3 ANATOMY & MORPHOLOGY
Stancho Stanchev, Lyubomir Gaydarski, Iva N Dimitrova, Georgi Kotov, Boycho Landzhov, Vidin Kirkov, Alexandar Iliev
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引用次数: 0

摘要

背景:动脉高血压是肾脏疾病的主要风险因素。最近的研究表明,凋亡素系统与肾脏稳态之间存在潜在联系:我们使用 6 个月和 12 个月大的自发性高血压大鼠和年龄匹配的正常血压对照组,通过免疫组化方法评估肾脏凋亡素受体表达的变化。研究还评估了肾脏凋亡素受体表达与肾损伤指标之间的相关性:组织学分析表明,与年龄匹配的对照组相比,两组高血压大鼠的肾小球硬化和肾小管间质损伤指数均有所升高。每组中年龄较大的大鼠比年龄较小的大鼠得分更高。免疫组化分析显示了不同的凋亡素受体表达模式,肾小管的表达随着高血压的严重程度和年龄的增长而增强。与正常血压对照组相比,老年高血压大鼠的肾小球表达明显较高。我们发现,在老年高血压动物中,肾小球凋亡素受体表达与肾小球硬化指数呈明显的正相关。同样,我们发现高血压大鼠肾小管凋亡素受体表达与肾小管间质损伤指数呈正相关,这表明凋亡素受体表达和肾损伤的变化与高血压有关:我们的研究发现了高血压大鼠肾脏的变化和不同的凋亡素受体相关性,这表明高血压大鼠肾脏的复杂作用有待研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Renal structural changes and apelin receptor expression in spontaneously hypertensive rats: implications for hypertension-induced kidney injury.

Background: Arterial hypertension is a primary risk factor for kidney disease. Recent advances have implied a potential link between the apelin system and renal homeostasis.

Materials and methods: We used 6- and 12-month-old spontaneously hypertensive rats and age-matched normotensive controls to assess the changes in the renal expression of the apelin receptor by immunohistochemical method. The study also evaluated correlations between the renal apelin receptor's expression and renal injury indicators.

Results: The histological analysis showed elevated glomerular sclerosis and tubulointerstitial damage indices in both groups of hypertensive rats compared to age-matched controls. Older rats within each group exhibited higher scores than younger ones. The immunohistochemical analysis revealed varying apelin receptor expression patterns, with tubular expression intensifying both with hypertension severity and age. Glomerular expression was notably higher in older hypertensive rats compared to normotensive controls. We reported significant positive correlations between glomerular apelin receptor expression and glomerular sclerosis index in older hypertensive animals. Similarly, a positive correlation between tubular apelin receptor expression and tubulointerstitial damage index was discovered in hypertensive rats, suggesting hypertension-related changes in apelin receptor expression and renal damage.

Conclusions: Our study found kidney changes and varying apelin receptor correlations in hypertensive rat kidneys, suggesting complex roles needing research.

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来源期刊
Folia morphologica
Folia morphologica ANATOMY & MORPHOLOGY-
CiteScore
2.40
自引率
0.00%
发文量
218
审稿时长
6-12 weeks
期刊介绍: "Folia Morphologica" is an official journal of the Polish Anatomical Society (a Constituent Member of European Federation for Experimental Morphology - EFEM). It contains original articles and reviews on morphology in the broadest sense (descriptive, experimental, and methodological). Papers dealing with practical application of morphological research to clinical problems may also be considered. Full-length papers as well as short research notes can be submitted. Descriptive papers dealing with non-mammals, cannot be accepted for publication with some exception.
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