精神疾病中的神经血管功能障碍:基本机制和治疗方法。

IF 4.4 3区 医学 Q1 MEDICINE, GENERAL & INTERNAL
Eliane Swely Sanches, Daniela Simões, Filipa Isabel Baptista, Ana Paula Silva
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引用次数: 0

摘要

背景:神经血管界面,特别是血脑屏障(BBB)和血视网膜屏障(BRB),在维持中枢神经系统(CNS)平衡方面发挥着关键作用。长期以来,这些结构只被视为一种保护方式,但我们现在知道,它们在中枢神经系统(功能障碍)中发挥着至关重要的作用。一些研究发现,神经血管在脑部和眼部疾病的早期阶段发生了改变,从而导致了这些疾病的病理生理学。最近,一些有趣的数据也强调了神经血管在精神疾病中的重要性:方法:我们利用 PubMed 数据库汇集了有关精神疾病情况下 BBB 和 BRB 变化的证据,重点关注焦虑症、重度抑郁症(MDD)、注意力缺陷/多动症(ADHD)和药物滥用,特别是与甲基苯丙胺(METH)和可卡因消费有关的情况:我们总结了体外研究、动物研究以及临床研究的主要发现,这些研究都是为了确定此类神经精神疾病的神经血管异常。我们研究了屏障改变的驱动因素,即神经炎症的作用,同时报告了这些疾病的屏障相关生物标志物:这篇综述强调了深入了解神经精神疾病中生物屏障和神经屏障功能的迫切需要,以及它们作为治疗靶点的潜力,同时阐明了其中的关键参与者。该综述还探讨了治疗这些复杂疾病的创新方法,同时弥补了目前对神经精神疾病及其血管影响之间关联的认识差距。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Neurovascular dysfunction in psychiatric disorders: Underlying mechanisms and therapeutic approaches.

Background: Neurovascular interfaces, specifically the blood-brain barrier (BBB) and blood-retinal barrier (BRB), play pivotal roles in maintaining the homeostasis of the central nervous system (CNS). For a long time, these structures were seen only as a way of protection, but we currently know that they have a critical role in CNS (dys)function. Several studies have identified neurovascular alterations in early stages of brain and eye diseases, contributing to the pathophysiology of such conditions. More recently, interesting data have also highlighted the importance of neurovasculature in psychiatric disorders.

Methods: Using the PubMed database, we brought together the evidence concerning the changes in BBB and BRB under psychiatric conditions, with a focus on anxiety, major depressive disorder (MDD), attention-deficit/hyperactivity disorder (ADHD) and drug abuse, specifically related with methamphetamine (METH) and cocaine consumption.

Results: We summarized the main findings obtained from in vitro and animal studies, as well as clinical research that has been undertaken to identify neurovascular abnormalities upon such neuropsychiatric disorders. The drivers of barrier alterations were examined, namely the role of neuroinflammation, while reporting putative barrier-associated biomarkers of these disorders.

Conclusion: This review underscores the critical need for a deeper understanding of BBB and BRB function in neuropsychiatric conditions and their potential as therapeutic targets while elucidating the key players involved. The innovative approaches to managing these complex disorders are also addressed while bridging the gap concerning what is currently known regarding the association between neuropsychiatric conditions and their vascular implications.

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来源期刊
CiteScore
9.50
自引率
3.60%
发文量
192
审稿时长
1 months
期刊介绍: EJCI considers any original contribution from the most sophisticated basic molecular sciences to applied clinical and translational research and evidence-based medicine across a broad range of subspecialties. The EJCI publishes reports of high-quality research that pertain to the genetic, molecular, cellular, or physiological basis of human biology and disease, as well as research that addresses prevalence, diagnosis, course, treatment, and prevention of disease. We are primarily interested in studies directly pertinent to humans, but submission of robust in vitro and animal work is also encouraged. Interdisciplinary work and research using innovative methods and combinations of laboratory, clinical, and epidemiological methodologies and techniques is of great interest to the journal. Several categories of manuscripts (for detailed description see below) are considered: editorials, original articles (also including randomized clinical trials, systematic reviews and meta-analyses), reviews (narrative reviews), opinion articles (including debates, perspectives and commentaries); and letters to the Editor.
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