他汀类药物治疗对糖尿病发病率的影响：对初级预防的影响

IF 3.1 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Current Cardiology Reports Pub Date : 2024-12-01 Epub Date: 2024-09-20 DOI:10.1007/s11886-024-02141-3

Rishi Rikhi, Michael D Shapiro

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引用次数: 0

摘要

综述目的：本综述旨在总结目前的证据，探索潜在的机制，并帮助指导临床医生了解他汀类药物治疗和一级预防中的糖尿病风险：观察性和遗传性流行病学以及随机对照试验和荟萃分析的证据表明，他汀类药物治疗会适度增加糖尿病风险，但增加程度与剂量有关。他汀类药物导致新发糖尿病的风险似乎在那些接近糖尿病诊断临界值或在开始服用他汀类药物前具有糖尿病风险因素的人群中最大。他汀类药物治疗对心血管的保护作用大大抵消了糖尿病的发病风险，因此，在一级预防中使用他汀类药物时，不应该受到指南建议的阻碍。

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Impact of Statin Therapy on Diabetes Incidence: Implications for Primary Prevention.

Purpose of review: The present review aims to summarize current evidence, explore underlying mechanisms, and help guide clinicians regarding statin therapy and diabetes risk in primary prevention.

Recent findings: The observational and genetic epidemiology, as well as evidence from randomized controlled trials and meta-analyses, illustrate a modest, dose-dependent increase in risk of diabetes from statin therapy. Risk of new onset diabetes from statins appears to be greatest in those near the diagnostic threshold for diabetes or with diabetes risk factors prior to statin initiation. The risk of incident diabetes is vastly offset by the cardiovascular protection offered from statin therapy and should not deter guideline recommended statin initiation in primary prevention.

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来源期刊

Current Cardiology Reports CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

6.20

自引率

2.70%

发文量

209

期刊介绍： The aim of this journal is to provide timely perspectives from experts on current advances in cardiovascular medicine. We also seek to provide reviews that highlight the most important recently published papers selected from the wealth of available cardiovascular literature. We accomplish this aim by appointing key authorities in major subject areas across the discipline. Section editors select topics to be reviewed by leading experts who emphasize recent developments and highlight important papers published over the past year. An Editorial Board of internationally diverse members suggests topics of special interest to their country/region and ensures that topics are current and include emerging research. We also provide commentaries from well-known figures in the field.