昼夜节律紊乱引起的认知障碍涉及海马脑源性神经营养因子减少和淀粉样蛋白-β沉积。

IF 2.2 4区 医学 Q2 BIOLOGY
Chronobiology International Pub Date : 2024-10-01 Epub Date: 2024-09-23 DOI:10.1080/07420528.2024.2406545
Yue-Jia Yan, Chang-Quan Huang
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引用次数: 0

摘要

昼夜节律紊乱与许多健康问题有关,包括认知能力下降和阿尔茨海默病(AD)等神经退行性疾病的恶化。脑源性神经营养因子(BDNF)对神经元的可塑性和认知功能至关重要,它受昼夜节律调节,对阿兹海默症有保护作用。因此,我们研究了昼夜节律紊乱(CRDs)对认知障碍的影响,并通过评估BDNF和淀粉样蛋白-β(Aβ)水平探讨了潜在的神经生物学机制。我们将雄性 C57BL/6 小鼠分为三组(n = 30):对照组(正常 12/12 小时光-暗周期)和两个 CRD 模型组(分别为 3/3 和 22/22 小时周期)。12 周后,我们使用莫里斯水迷宫评估认知功能。行为测试后,我们使用酶联免疫吸附试验对海马中的BDNF和Aβ水平进行了定量分析。CRD明显损害了学习和记忆能力,这表现在CRD组到达和找到平台的时间更长(P P
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cognitive impairment induced by circadian rhythm disorders involves hippocampal brain-derived neurotrophic factor reduction and amyloid-β deposition.

Circadian rhythm disruptions have been implicated in numerous health issues, including cognitive decline and the exacerbation of neurodegenerative diseases, like Alzheimer disease (AD). Brain-derived neurotrophic factor (BDNF), vital for neuronal plasticity and cognitive function, is regulated by the circadian clock and exerts protective effects against AD. Thus, we investigated the impact of circadian rhythm disorders (CRDs) on cognitive impairment and explored the underlying neurobiological mechanisms by assessing BDNF and amyloid-β (Aβ) levels. We divided male C57BL/6 mice into three groups (n = 30): a control group (normal 12/12 hour light-dark cycle) and two CRD model groups (3/3 and 22/22 hour cycles, respectively). After 12 weeks, we assessed cognitive functions using the Morris water maze. Following behavioral tests, hippocampal levels of BDNF and Aβ were quantified using enzyme-linked immunosorbent assays. CRDs significantly impaired learning and memory, as evidenced by longer times to reach and find the platform in the CRD groups (p < 0.01). Furthermore, BDNF levels were notably decreased and Aβ levels increased in the CRD groups compared with the control group (p < 0.01). Thus, CRDs elicit cognitive impairment by reducing BDNF levels and increasing Aβ deposition in the hippocampus.

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来源期刊
Chronobiology International
Chronobiology International 生物-生理学
CiteScore
5.60
自引率
7.10%
发文量
110
审稿时长
1 months
期刊介绍: Chronobiology International is the journal of biological and medical rhythm research. It is a transdisciplinary journal focusing on biological rhythm phenomena of all life forms. The journal publishes groundbreaking articles plus authoritative review papers, short communications of work in progress, case studies, and letters to the editor, for example, on genetic and molecular mechanisms of insect, animal and human biological timekeeping, including melatonin and pineal gland rhythms. It also publishes applied topics, for example, shiftwork, chronotypes, and associated personality traits; chronobiology and chronotherapy of sleep, cardiovascular, pulmonary, psychiatric, and other medical conditions. Articles in the journal pertain to basic and applied chronobiology, and to methods, statistics, and instrumentation for biological rhythm study. Read More: http://informahealthcare.com/page/cbi/Description
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